2-苯基苯胺盐酸盐 | 2185-92-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-苯基苯胺盐酸盐
• 中文别名: 2-氨基联苯盐酸盐
• 英文名称: 2-Biphenylylamine hydrochloride
• 英文别名: 2-biphenylammonium chloride；o-phenylaniline hydrochloride；2-biphenylamine hydrochloride；2-phenylaniline hydrochloride；biphenyl-2-ylamine; hydrochloride；2-aminobiphenyl hydrochloride；hydron;2-phenylaniline;chloride
• CAS: 2185-92-4
• 化学式: C₁₂H₁₁N*ClH
• 分子量: 205.687
• InChiKey: QHYYXPLERUSFAV-UHFFFAOYSA-N

物化性质

• 物理描述：
  2-biphenylamine hydrochloride appears as pale yellow crystals or off-white chunky solid. (NTP, 1992)
• 熔点：
  387 °F (possible decomposition) (NTP, 1992)
• 溶解度：
  less than 1 mg/mL at 72° F (NTP, 1992)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.77
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  27.6
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2921499090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 2-Aminobiphenyl, HCl
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 2-Aminobiphenyl, HCl
CAS number: 2185-92-4

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C12H12ClN
Molecular weight: 205.7

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

类别：有毒物品

可燃性危险特性：

• 可燃；燃烧时产生有毒的氮氧化物和氯化氢烟雾。

储运特性：

• 通风、低温、干燥

灭火剂：

• 干粉、泡沫、沙土、二氧化碳、雾状水

反应信息

• 作为反应物：
  描述：

  2-苯基苯胺盐酸盐 在 二氯化二硫 作用下， 反应 5.0h， 生成 6-chloro-4-phenyl-benzo[1,2,3]dithiazolylium; chloride
  参考文献：
  名称：

  Berti,G. et al., Gazzetta Chimica Italiana, 1977, vol. 107, p. 175 - 180

  摘要：

  DOI：
• 作为产物：
  描述：

  2-硝基联苯 在 盐酸 、 tin(ll) chloride 作用下， 以 乙醇 、 水 为溶剂， 生成 2-苯基苯胺盐酸盐
  参考文献：
  名称：

  Steric acceleration by ortho substituents of the stannous chloride reduction of nitrobenzenes in aqueous ethanol

  摘要：

  DOI：

  10.1021/jo00139a048

文献信息

• [EN] STAT DEGRADERS AND USES THEREOF<br/>[FR] AGENTS DE DÉGRADATION DE STAT ET LEURS UTILISATIONS
  申请人：KYMERA THERAPEUTICS INC

  公开号：WO2021188696A1

  公开（公告）日：2021-09-23

  The present invention provides compounds, compositions thereof, and methods of using the same.

  本发明提供了化合物、其组合物以及使用相同的方法。
• [EN] INHIBITORS OF RAF KINASES<br/>[FR] INHIBITEURS DE KINASES RAF
  申请人：KINNATE BIOPHARMA INC

  公开号：WO2020227020A1

  公开（公告）日：2020-11-12

  Provided herein are heteroaryl inhibitors of receptor tyrosine kinase effector (RAF), pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of disease.

  本文件提供了受体酪氨酸激酶效应器（RAF）的杂芳基抑制剂，包括含有该化合物的药物组合物，以及使用这些化合物治疗疾病的方法。
• NAPHTHYRIDINES AS INHIBITORS OF HPK1
  申请人：Genentech, Inc.

  公开号：US20180282328A1

  公开（公告）日：2018-10-04

  Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.

  萘啶化合物及其作为HPK1抑制剂的用途被描述。这些化合物在治疗HPK1依赖性疾病和增强免疫反应方面很有用。还描述了抑制HPK1的方法、治疗HPK1依赖性疾病的方法、增强免疫反应的方法以及制备萘啶化合物的方法。
• [EN] GOLD COMPOUNDS AND THEIR USE IN THERAPY<br/>[FR] COMPOSÉS D'OR ET LEUR UTILISATION DANS LE CADRE D'UNE THÉRAPIE
  申请人：AUSPHERIX LTD

  公开号：WO2018220171A1

  公开（公告）日：2018-12-06

  Compound of formula (I) and pharmaceutically acceptable salts and solvates thereof are described, wherein: Px selected from (P1), (P2) or (P3); The compounds are useful in the prevention or treatment of a bacterial infection.

  描述了化合物的公式（I）及其药用可接受的盐和溶剂化合物，其中：Px选自（P1）、（P2）或（P3）；这些化合物在预防或治疗细菌感染方面是有用的。
• Biphenyl-substituted guanidine derivatives useful as hypoglycaemic agents
  申请人：The Boots Company

  公开号：US05302720A1

  公开（公告）日：1994-04-12

  Compounds of formula I ##STR1## and their salts in which R.sub.1 is optionally substituted phenyl, R.sub.2 is alkyl, cycloalkyl or optionally substituted amino, or R.sub.2 and R.sub.3 together with the nitrogen and carbon atoms to which they are attached form an optionally substituted heterocyclic ring or R.sub.3 and R.sub.4 together with the nitrogen atom to which they are attached form an optionally substituted heterocyclic ring and R.sub.5 is H, halo, alkyl, alkoxy, trifluoromethyl or a group of formula S(O).sub.m R.sub.8 in which m is 0, 1 or 2 and R.sub.8 is alkyl have utility in the treatment of diabetes particularly in the treatment of hyperglycaemia.

  化合物的化学式I ##STR1## 及其盐，其中R.sub.1 可选择地是取代苯基，R.sub.2 是烷基、环烷基或可选择地取代的氨基，或者R.sub.2 和R.sub.3 与它们连接的氮和碳原子一起形成可选择地取代的杂环环或者R.sub.3 和R.sub.4 与它们连接的氮原子一起形成可选择地取代的杂环环，R.sub.5 是H、卤素、烷基、烷氧基、三氟甲基或者化学式S(O).sub.m R.sub.8 的基团，其中m 为0、1 或2，R.sub.8 是烷基，在糖尿病治疗中特别在高血糖治疗中具有用途。