N-((1S,3R)-3-(dimethylamino)-2,2,3-trimethylcyclopentyl)-4-methylbenzene-sulfonamide | 1220123-31-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-((1S,3R)-3-(dimethylamino)-2,2,3-trimethylcyclopentyl)-4-methylbenzene-sulfonamide
• CAS: 1220123-31-8
• 化学式: C₁₇H₂₈N₂O₂S
• 分子量: 324.488
• InChiKey: AROAZWAGCXJZGI-DOTOQJQBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.78
• 重原子数：
  22.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  49.41
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 N-((1S,3R)-3-amino-2,2,3-trimethylcyclopentyl)-4-methylbenzenesulfonamide 在 甲酸 、 盐酸 、 sodium hydroxide 作用下， 以 水 为溶剂， 以44%的产率得到N-((1S,3R)-3-(dimethylamino)-2,2,3-trimethylcyclopentyl)-4-methylbenzene-sulfonamide
  参考文献：
  名称：

  Enantioselective ethylation of aldehydes with 1,3-N-donor ligands derived from (+)-camphoric acid

  摘要：

  Derivatives of (+)-camphoric acid were prepared by a short and simple synthetic sequence and proved to be excellent ligands for the enantioselective ethylation of benzaldellyde with diethylzinc, with ees of up to 96% being obtained The most efficient ligand was tested with several aromatic alclehydes and ees of up to 99% were observed Structural features of the ligands are determinant for achieving high enantioselectivities. (c) 2009 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tetasy.2009.12.012

文献信息

• Enantioselective ethylation of aldehydes with 1,3-N-donor ligands derived from (+)-camphoric acid
  作者：Dina Murtinho、M. Elisa Silva Serra、A.M.d’A. Rocha Gonsalves

  DOI：10.1016/j.tetasy.2009.12.012

  日期：2010.1

  Derivatives of (+)-camphoric acid were prepared by a short and simple synthetic sequence and proved to be excellent ligands for the enantioselective ethylation of benzaldellyde with diethylzinc, with ees of up to 96% being obtained The most efficient ligand was tested with several aromatic alclehydes and ees of up to 99% were observed Structural features of the ligands are determinant for achieving high enantioselectivities. (c) 2009 Elsevier Ltd All rights reserved