exo-2-Carbomethoxy-7-oxabicyclo<2.2.1>heptan | 132747-22-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: exo-2-Carbomethoxy-7-oxabicyclo<2.2.1>heptan
• 英文别名: methyl (1S,2R,4R)-7-oxabicyclo[2.2.1]heptan-2-carboxylate；Methyl (1S,2R,4R)-7-oxabicyclo[2.2.1]heptane-2-carboxylate
• CAS: 132747-22-9
• 化学式: C₈H₁₂O₃
• 分子量: 156.181
• InChiKey: UYMKMUZNHJKUQB-QYNIQEEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  7-oxa-2,2-bis(carbomethoxy)bicyclo<2.2.1>heptane 、 氯化锂 生成 exo-2-Carbomethoxy-7-oxabicyclo<2.2.1>heptan
  参考文献：
  名称：

  BANKS H. D., J. ORG. CHEM., 1981, 46, NO 8, 1743-1745

  摘要：

  DOI：

文献信息

• Boronic acid derivatives
  申请人：Merck Patent GmbH

  公开号：US11274109B2

  公开（公告）日：2022-03-15

  α-amino boronic acid derivatives are useful for inhibiting the activity of immunoproteasome (LMP7) and for the treatment and/or prevention of medical conditions affected by immunoproteasome activity such as inflammatory and autoimmune diseases, neurodegenerative diseases, proliferative diseases and cancer.

  α-氨基硼酸衍生物可用于抑制免疫蛋白酶体（LMP7）的活性，治疗和/或预防受免疫蛋白酶体活性影响的疾病，如炎症和自身免疫性疾病、神经退行性疾病、增殖性疾病和癌症。
• KOTSUKI, HIYOSHIZO;NISHIZAWA, HITOSHI;OCHI, MASAMITSU;MATSUOKA, KIYOSHI, BULL. CHEM. SOC. JAP., 1982, 55, N 2, 496-499
  作者：KOTSUKI, HIYOSHIZO、NISHIZAWA, HITOSHI、OCHI, MASAMITSU、MATSUOKA, KIYOSHI

  DOI：——

  日期：——
• Boronic Acid Derivatives
  申请人：Merck Patent GmbH

  公开号：US20200354382A1

  公开（公告）日：2020-11-12

  α-amino boronic acid derivatives are useful for inhibiting the activity of immunoproteasome (LMP7) and for the treatment and/or prevention of medical conditions affected by immunoproteasome activity such as inflammatory and autoimmune diseases, neurodegenerative diseases, proliferative diseases and cancer.