N-[2-(1H-benzimidazol-2-yl)phenyl]-4-methoxy-3-(morpholin-4-ylmethyl)benzamide | 1159340-06-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: N-[2-(1H-benzimidazol-2-yl)phenyl]-4-methoxy-3-(morpholin-4-ylmethyl)benzamide
• CAS: 1159340-06-3
• 化学式: C₂₆H₂₆N₄O₃
• 分子量: 442.517
• InChiKey: XDPKGIFUGQEWKO-UHFFFAOYSA-N

物化性质

• 密度：
  1.298±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  79.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-(2-氨基苯基)苯并咪唑 、 4-methoxy-3-(morpholinomethyl)benzoyl chloride 在 吡啶 作用下， 反应 0.17h， 生成 N-[2-(1H-benzimidazol-2-yl)phenyl]-4-methoxy-3-(morpholin-4-ylmethyl)benzamide
  参考文献：
  名称：

  Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators

  摘要：

  SIRT1 is an NAD(+)-dependent protein deacetylase that appears to produce beneficial effects on metabolic parameters such as glucose and insulin homeostasis. Activation of SIRT1 by resveratrol ( 1) has been shown to modulate insulin resistance, increase mitochondrial content and prolong survival in lower organisms and in mice on a high fat diet. Herein, we describe the identification and SAR of a series of oxazolo[4,5-b]pyridines as novel small molecule activators of SIRT1 which are structurally unrelated to and more potent than resveratrol. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2008.11.106