5-(Hydroxyphenylmethyl)pyrazol | 19854-91-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(Hydroxyphenylmethyl)pyrazol
• 英文别名: phenyl(1H-pyrazol-5-yl)methanol
• CAS: 19854-91-2
• 化学式: C₁₀H₁₀N₂O
• 分子量: 174.202
• InChiKey: CPEXMLRNLBFIHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  48.9
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(Dimethylsulfamoyl)-5-(hydroxyphenylmethyl)pyrazol 在 溶剂黄146 作用下， 以56%的产率得到5-(Hydroxyphenylmethyl)pyrazol
  参考文献：
  名称：

  Effenberger, Franz; Roos, Michael; Ahmad, Roshan, Chemische Berichte, 1991, vol. 124, p. 1639 - 1650

  摘要：

  DOI：

文献信息

• Formaldehyde: A Reagent for Simultaneous Protection of Heterocyclic NH and Activation of Alternative Locations to Electrophilic Attack. Part II. A New Synthetic Method for the 5(3)-Substitution of N-Unsubstituted Pyrazoles
  作者：Alan R. Katritzky、Ping Lue、Kunihiko Akutagawa

  DOI：10.1016/s0040-4020(01)81320-x

  日期：1989.1

  N-Unsubstituted pyrazole 1 is readily converted into 5-substituted [tautomeric with 3-substituted 8] derivatives 2 in moderate to good overall yields in a one-pot sequence, using formaldehyde both for N-protection and to mediate lithiation at the 5-position. The dilithiohemiaminals 5 react with electrophiles at the pyrazole 5-position to give 5-substituted 1-lithioxymethylpyrazoles 6 which undergo

  N-未取代的吡唑1易于以一锅法以中等到良好的总收率转化为5取代的[与3取代的8的互变异构体]衍生物2，同时使用甲醛进行N保护和介导5位的锂化反应。位置。所述dilithiohemiaminals 5与亲电子在吡唑的5位反应以得到5-取代的1- lithioxymethylpyrazoles 6中经历温和的条件下顺利dehydroxymethylation（酸水解或硅胶），得到N-未取代的5（3） -取代的吡唑。
• THIENYLAZOLYLALCOXYETHANAMINES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP1072266A1

  公开（公告）日：2001-01-31

  The thienylazolylalkoxyethanamines (I) where R1 is a hydrogen atom, a halogen atom or a lower alkyl radical; R2, R3 and R4 represent, independently, a hydrogen atom or a lower alkyl radical; and Az represents a five-member nitrogenated hetercyclic aromatic group, N-methyl-substituted, that contains from one to three nitrogen atoms. They have analgesic activity in mammals, including humans. The compounds (I) can be obtained, for example, by reaction of a derivative of hydroxy-thienylazol (IV) with a derivative of a suitable N-(ethyl)amine. The compounds (IV) are useful intermediates in the synthesis of the compounds (I). The compounds (I) have an application in human and/or veterinary medicine.

  噻唑烷氧基乙胺（I），其中 R1 是氢原子、卤素原子或低级烷基；R2、R3 和 R4 分别代表氢原子或低级烷基；Az 代表含有 1 至 3 个氮原子的 N-甲基取代的五元氮杂环芳香基团。它们对包括人类在内的哺乳动物具有镇痛活性。例如，通过羟基噻吩唑的衍生物（IV）与合适的 N-（乙基）胺的衍生物反应，可以得到化合物（I）。化合物（IV）是合成化合物（I）的有用中间体。化合物 (I) 可应用于人类和/或兽医领域。
• Thienylazolylalkoxyethanamines, their preparation and their application as medicaments
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：US20020188017A1

  公开（公告）日：2002-12-12

  The thienylazolylalkoxyethanamines (I) where R1 is a hydrogen atom, a halogen atom or a lower alkyl radical; R2, R3 and R4 represent, independently, a hydrogen atom or a lower alkyl radical; and Az represents a five-member nitrogenated hetercyclic aromatic group, N-methyl-substituted, that contains from one to three nitrogen atoms. They have analgesic activity in mammals, including humans. The compounds (I) can be obtained, for example, by reaction of a derivative of hydroxy-thienylazol (IV) with a derivative of a suitable N-(ethyl)amine. The compounds (IV) are useful intermediates in the synthesis of the compounds (I). The compounds (I) have an application in human and/or veterinary medicine.

  噻唑烷氧基乙胺（I），其中 R1 是氢原子、卤素原子或低级烷基；R2、R3 和 R4 分别代表氢原子或低级烷基；Az 代表含有 1 至 3 个氮原子的 N-甲基取代的五元氮杂环芳香基团。 它们对包括人类在内的哺乳动物具有镇痛活性。 例如，通过羟基噻吩唑的衍生物（IV）与合适的 N-（乙基）胺的衍生物反应，可以得到化合物（I）。 化合物（IV）是合成化合物（I）的有用中间体。 化合物 (I) 可应用于人类和/或兽医领域。
• 4-Methoxybenzyl (PMB), A Versatile Protecting Group for the Regiospecific Lithiation and Functionalization of Pyrazoles
  作者：Chakrapani Subramanyam

  DOI：10.1080/00397919508011414

  日期：1995.3

  The use of 4-methoxybenzyl (PMB) protecting group for the regiospecific metallation/functionalisation of pyrazole is reported.
• EFFENBERGER, FRANZ;ROOS, MICHAEL;AHMAD, ROSHAN;KREBS, ANDREAS, CHEM. BER., 124,(1991) N, C. 1639-1650
  作者：EFFENBERGER, FRANZ、ROOS, MICHAEL、AHMAD, ROSHAN、KREBS, ANDREAS

  DOI：——

  日期：——