3β,6β-dihydroxy-5α-cholanoic acid | 2448-47-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3β,6β-dihydroxy-5α-cholanoic acid
• 英文别名: 3β.6β-dihydroxy-5α-cholanoic acid-(24)；3β.6β-Dihydroxy-5α-cholansaeure-(24)；3beta,6beta-Dihydroxy-5alpha-cholan-24-oic Acid；(4R)-4-[(3S,5S,6R,8S,9S,10R,13R,14S,17R)-3,6-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
• CAS: 2448-47-7
• 化学式: C₂₄H₄₀O₄
• 分子量: 392.579
• InChiKey: DGABKXLVXPYZII-VDMUPYQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3β,6β-dihydroxy-5α-cholanoic acid 在 chromium(VI) oxide 、 硫酸 、 溶剂黄146 作用下， 生成 5α-cholanic acid-3,6-dione
  参考文献：
  名称：

  Windaus, Justus Liebigs Annalen der Chemie, 1926, vol. 447, p. 233,253

  摘要：

  DOI：
• 作为产物：
  描述：

  5α-cholanic acid-3,6-dione 在 溶剂黄146 、 铂 作用下， 生成 3β,6β-dihydroxy-5α-cholanoic acid
  参考文献：
  名称：

  Sterols. CXXX. 3,6-Diketo Sterols and their Reduction Products^*

  摘要：

  DOI：

  10.1021/ja01254a006

文献信息

• Interactions between GABAergic and aminoacidergic pathways in the control of gonadotropin and GH secretion in pre-pubertal female rats
  作者：L. Pinilla、L. C. González、M. Tena-Sempere、Enrique Aguilar

  DOI：10.1007/bf03343970

  日期：2002.2

  Present experiments were carried out in 23-day-old female rats to analyze the interaction between excitatory amino acids (EAAs) and gamma-aminobutyric acid (GABA) in the control of gonadotropin and GH secretion. For this purpose, serum concentrations of LH, FSH and GH were measured after injection of different agonists of EAA receptor subtypes [N-methyl-D-aspartate (NMDA); kainic acid (KA), +/--alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)], antagonists of GABA receptors (bicuculline, phaclofen) or the combined administration of both types of drugs. The results obtained indicated that: 1) GABA has a minor physiological role in the control of LH and GH secretion, since neither LH nor GH serum concentrations changed after administration of bicuculline (antagonist of GABA(A) receptors) or phaclofen (antagonist of GABA(B) receptors); 2) GABA has a sex-specific physiological role in the control of FSH secretion in female rats, in which FSH secretion increases after phaclofen administration; 3) GH secretion was enhanced after administration of NMDA, KA and AMPA, while LH increased only after activation of NMDA receptors; 4) the stimulatory effect of NMDA on LH secretion was counteracted by administration of phaclofen; and 5) bicuculline and phaclofen reduced the ability of NMDA and AMPA to stimulate GH secretion. In conclusion, present experiments evidenced a physiological role of GABA, mediated by GABA(B) receptors, in the control of FSH secretion and a cross-talk between excitatory and inhibitory amino acids in the control of anterior pituitary secretion. (C) 2002, Editrice Kurtis.
• Steroidal oxidation product and method of obtaining same
  申请人：PARKE DAVIS & CO

  公开号：US02337564A1

  公开（公告）日：1943-12-28
• Wieland; Dane; Martius, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1933, vol. 215, p. 15,22
  作者：Wieland、Dane、Martius

  DOI：——

  日期：——
• Hydroxy steroids and method of obtaining same
  申请人：PARKE DAVIS & CO

  公开号：US02337563A1

  公开（公告）日：1943-12-28
• Tsukamoto, Journal of Biochemistry, 1940, vol. 32, p. 461,462
  作者：Tsukamoto

  DOI：——

  日期：——