4-(4-chlorophenoxy)-2-methyl-aniline | 946743-01-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(4-chlorophenoxy)-2-methyl-aniline
• 英文别名: 4-(4-Chlorophenoxy)-2-methylaniline
• CAS: 946743-01-7
• 化学式: C₁₃H₁₂ClNO
• mdl: MFCD08687440
• 分子量: 233.697
• InChiKey: KYZMHOKELOMGHH-UHFFFAOYSA-N

物化性质

• 沸点：
  358.3±32.0 °C(Predicted)
• 密度：
  1.226±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.076
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2922299090

反应信息

• 作为反应物：
  描述：

  4-(4-chlorophenoxy)-2-methyl-aniline 在 N-溴代丁二酰亚胺(NBS) 、 亚硝酸特丁酯 、 copper(ll) bromide 、 过氧化苯甲酰 作用下， 以 四氯化碳 、 乙腈 为溶剂， 生成 1-Bromo-2-(bromomethyl)-4-(4-chlorophenoxy)benzene
  参考文献：
  名称：

  Boron-Containing Small Molecules as Anti-Inflammatory Agents

  摘要：

  化合物和治疗抗炎症状况的方法被披露。

  公开号：

  US20150291629A1
• 作为产物：
  描述：

  4-(4-Chlorophenoxy)-2-methyl-1-nitrobenzene 在 盐酸 、 tin(ll) chloride 作用下， 以 水 为溶剂， 反应 1.0h， 以97%的产率得到4-(4-chlorophenoxy)-2-methyl-aniline
  参考文献：
  名称：

  Boron-Containing Small Molecules as Anti-Inflammatory Agents

  摘要：

  化合物和治疗抗炎症状况的方法被披露。

  公开号：

  US20150291629A1

文献信息

• Soluble, low dielectrical constant, unsymmetrical polyimide and a method for preparing the same
  申请人：Zhang Suobo

  公开号：US20060235192A1

  公开（公告）日：2006-10-19

  The present invention relates to a soluble unsymmetrical polyimide and a method for preparing the same. The soluble unsymmetrical polyimide can be obtained by polymerizing an easily prepared dihalogen-substituted phthalimide as the monomer in the presence of transition metal nickel catalyst. In the polymerization process, the linkage of C-C bond in polymer has modes of head-to head, tail to tail and head to tail. The solubility of the unsymmetrical polyimide originates from the unsymmetrical nature of the polymer. Only those improved unsymmetrical polyimide has excellent solubility, high mechanical properties, thermal stability, low dielectric constant and low linear expansion coefficient. The present invention directly synthesizes the unsymmetrical polyimide by means of coupling reaction. Thus, not only the steps of synthesizing dianhydride and diamine are omitted, but also the properties of the polymer are improved and the production cost is greatly reduced.

  本发明涉及一种可溶性非对称聚酰亚胺及其制备方法。该可溶性非对称聚酰亚胺可通过在过渡金属镍催化剂存在下聚合易于制备的二卤代邻苯二酰亚胺单体而得到。在聚合过程中，聚合物中的C-C键连接方式有头对头、尾对尾和头对尾。非对称聚酰亚胺的溶解度源于聚合物的非对称性。只有那些改进的非对称聚酰亚胺具有优异的溶解度、高机械性能、热稳定性、低介电常数和低线性膨胀系数。本发明通过偶联反应直接合成非对称聚酰亚胺。因此，不仅省略了合成二酸酐和二胺的步骤，而且改善了聚合物的性能，大大降低了生产成本。
• BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS
  申请人：Akama Tsutomu

  公开号：US20120214765A1

  公开（公告）日：2012-08-23

  Compounds and methods of treating anti-inflammatory conditions are disclosed.

  本发明公开了治疗抗炎症状况的化合物和方法。
• Boron-containing small molecules as anti-inflammatory agents
  申请人：Anacor Pharmaceuticals, Inc.

  公开号：EP2564857A1

  公开（公告）日：2013-03-06

  Compounds and methods of treating anti-inflammatory conditions are disclosed. The compounds are benzoxaboroles and in particular are 5-phenoxy-1-hydroxy-2,1-benzoxaboroles and 5-pyridin-2-yloxy-1-hydroxy-2,1-benzoxaboroles.

  本发明公开了治疗抗炎症状的化合物和方法。这些化合物是苯并氧硼烷，特别是 5-苯氧基-1-羟基-2,1-苯并氧硼烷和 5-吡啶-2-基氧基-1-羟基-2,1-苯并氧硼烷。
• Method for preparing poly(carbonate-etherimide) compound
  申请人：PTT Global Chemical Public Company Limited

  公开号：US10759904B2

  公开（公告）日：2020-09-01

  The present invention relates to a method for preparing poly(carbonate-etherimide) compound comprising polycarbonate segment as shown in the structure (A) and polyetherimide segment as shown in the structure (B). Said method does not contain a highly toxic phosgene in its operation, can be performed easily, and can be operated at not high temperature. wherein R1 represents aromatic with 6 to 30 carbon atoms or, optionally said aromatic is bonded with heteroatom; R2 represents aromatic with 6 to 30 carbon atoms or, optionally said aromatic is bonded with heteroatom; m is an integer from 1 to 15; and n is an integer from 1 to 10.

  本发明涉及一种制备聚(碳酸酯-乙醚酰亚胺)化合物的方法，该化合物由结构(A)所示的聚碳酸酯段和结构(B)所示的聚醚酰亚胺段组成。本发明涉及一种制备聚碳酸酯-乙烯酰亚胺化合物的方法，该化合物包括结构（A）所示的聚碳酸酯段和结构（B）所示的聚醚酰亚胺段，该方法在操作过程中不含有剧毒的光气，操作简便，可在不高的温度下进行。
• The discovery of aminopyrazines as novel, potent Nav1.7 antagonists: Hit-to-lead identification and SAR
  作者：Howard Bregman、Hanh Nho Nguyen、Elma Feric、Joseph Ligutti、Dong Liu、Jeff S. McDermott、Ben Wilenkin、Anruo Zou、Liyue Huang、Xingwen Li、Stefan I. McDonough、Erin F. DiMauro

  DOI：10.1016/j.bmcl.2012.01.023

  日期：2012.3

  Herein the discovery of a novel class of aminoheterocyclic Na(v)1.7 antagonists is reported. Hit compound 1 was potent but suffered from poor pharmacokinetics and selectivity. The compact structure of 1 offered a modular synthetic strategy towards a broad structure-activity relationship analysis. This analysis led to the identification of aminopyrazine 41, which had vastly improved hERG selectivity and pharmacokinetic properties. (C) 2012 Elsevier Ltd. All rights reserved.