4-t-butyl-α-(p-toluenesulfonylamido)ethylbenzene | 888188-20-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-t-butyl-α-(p-toluenesulfonylamido)ethylbenzene
• 英文别名: N-[1-(4-tert-butylphenyl)ethyl]-4-methylbenzenesulfonamide
• CAS: 888188-20-3
• 化学式: C₁₉H₂₅NO₂S
• 分子量: 331.479
• InChiKey: NTODGAWSKUAKGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-叔丁基苯乙烯 、 对甲苯磺酰胺 在 碘 作用下， 以 甲苯 为溶剂， 反应 2.5h， 以85%的产率得到4-t-butyl-α-(p-toluenesulfonylamido)ethylbenzene
  参考文献：
  名称：

  Iodine-catalyzed intermolecular hydroamination of vinyl arenes

  摘要：

  The vinyl arenes undergo smooth hydroamination with sulfonamides in the presence of 10 mol% of iodine to furnish tosyl and mesyl-protected secondary amines in excellent yields ill Short reaction times. The use of inexpensive and readily available molecular iodine makes this method quite simple, more convenient, and practical. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.07.010

文献信息

• Sulfonylamidation of alkylbenzenes at benzylic position with p-toluenesulfonamide and 1,3-diiodo-5,5-dimethylhydantoin
  作者：Haruka Baba、Hideo Togo

  DOI：10.1016/j.tetlet.2010.02.060

  日期：2010.4

  Treatment of alkylbenzenes with p-toluenesulfonamide and 1,3-diiodo-5,5-dimethylhydantoin (DIH) in a small amount of carbon tetrachloride at 60 °C gave the corresponding α-p-toluenesulfonylamido)alkylbenzenes in good to moderate yields. The present reaction is a simple method for the α-sulfonylamidation of the benzylic position in alkylbenzenes.

  与烷基苯的治疗p在60四氯化碳少量-toluenesulfonamide和1,3-二碘-5,5-二甲基（DIH）℃，得到相应的α- p良好-toluenesulfonylamido）烷基苯至适中的产率。本反应是用于烷基苯中的苄基位置的α-磺酰胺化的简单方法。
• Iodine-catalyzed intermolecular hydroamination of vinyl arenes
  作者：J.S. Yadav、B.V. Subba Reddy、T. Srinivasa Rao、B. Bala M. Krishna

  DOI：10.1016/j.tetlet.2009.07.010

  日期：2009.9

  The vinyl arenes undergo smooth hydroamination with sulfonamides in the presence of 10 mol% of iodine to furnish tosyl and mesyl-protected secondary amines in excellent yields ill Short reaction times. The use of inexpensive and readily available molecular iodine makes this method quite simple, more convenient, and practical. (C) 2009 Elsevier Ltd. All rights reserved.