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2’-脱氧-2’,2’-二氟胸苷 | 95058-80-3

中文名称
2’-脱氧-2’,2’-二氟胸苷
中文别名
2'-脱氧-2',2'-二氟胸苷
英文名称
1-(2-deoxy-2,2-difluoro-β-D-erythro-pentofuranos-1-yl)thymine
英文别名
2'-Deoxy-2',2'-difluoro Thymidine;1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
2’-脱氧-2’,2’-二氟胸苷化学式
CAS
95058-80-3
化学式
C10H12F2N2O5
mdl
——
分子量
278.212
InChiKey
FKWSSJHRJXJIMZ-ATRFCDNQSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 密度:
    1.61±0.1 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    -0.9
  • 重原子数:
    19
  • 可旋转键数:
    2
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.6
  • 拓扑面积:
    99.1
  • 氢给体数:
    3
  • 氢受体数:
    7

反应信息

  • 作为产物:
    描述:
    参考文献:
    名称:
    Design, synthesis and biological evaluation of 2′-deoxy-2′,2′-difluoro-5-halouridine phosphoramidate ProTides
    摘要:
    We report the synthesis of a series of novel 2'-deoxy-2',2'-difluoro-5-halouridines and their corresponding phosphoramidate ProTides. All compounds were evaluated for antiviral activity and for cellular toxicity. Interestingly, 2'-deoxy-2',2'-difluoro-5-iodo- and -5-bromo-uridines showed selective activity against feline herpes virus replication in cell culture due to a specific recognition (activation) by the virus-encoded thymidine kinase. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
    DOI:
    10.1016/j.bmc.2011.05.037
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文献信息

  • Mutagenic nucleoside analogs for the treatment of viral disease
    申请人:Koronis Pharmaceuticals, Inc.
    公开号:US20030170872A1
    公开(公告)日:2003-09-11
    The present invention relates to methods of treating viral disease using mutagenic nucleoside analogs.
    本发明涉及使用诱变核苷类似物治疗病毒性疾病的方法。
  • EP1425022A4
    申请人:——
    公开号:EP1425022A4
    公开(公告)日:2009-04-29
  • MUTAGENIC NUCLEOSIDE ANALOGS FOR THE TREATMENT OF VIRAL DISEASE
    申请人:Koronis Pharmaceuticals, Inc.
    公开号:EP1425022A1
    公开(公告)日:2004-06-09
  • Mutagenic Nucleoside Analogs for the Treatment of Viral Disease
    申请人:Li Ling
    公开号:US20100279968A1
    公开(公告)日:2010-11-04
    The present invention relates to methods of treating viral disease using mutagenic nucleoside analogs.
  • US7244717B2
    申请人:——
    公开号:US7244717B2
    公开(公告)日:2007-07-17
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