(3,4-dihydro-1H-isoquinolin-2-yl)-carbamic acid 4-tert-butoxycarbonylamino-phenyl ester | 374567-13-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3,4-dihydro-1H-isoquinolin-2-yl)-carbamic acid 4-tert-butoxycarbonylamino-phenyl ester
• 英文别名: [4-[(2-methylpropan-2-yl)oxycarbonylamino]phenyl] N-(3,4-dihydro-1H-isoquinolin-2-yl)carbamate
• CAS: 374567-13-2
• 化学式: C₂₁H₂₅N₃O₄
• 分子量: 383.447
• InChiKey: IDMNLAYMNLOJLR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  79.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (3,4-dihydro-1H-isoquinolin-2-yl)-carbamic acid 4-tert-butoxycarbonylamino-phenyl ester 在 盐酸 、 甲酸 作用下， 以 四氢呋喃 为溶剂， 生成 (3,4-Dihydro-1H-isoquinolin-2-yl)-carbamic Acid 4-amino-phenyl Ester Hydrochloride
  参考文献：
  名称：

  Compounds for treating disorders where a decreased level of plasma FFA is desired

  摘要：

  这项发明涉及新化合物、含有这些化合物的组合物，以及它们用于治疗需要降低血浆游离脂肪酸（FFA）水平的医学疾病的用途。

  公开号：

  US20020082254A1
• 作为产物：
  描述：

  1,2,3,4-四氢-2-亚硝基-异喹啉 在 lithium aluminium tetrahydride 、 N,N-二异丙基乙胺 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 (3,4-dihydro-1H-isoquinolin-2-yl)-carbamic acid 4-tert-butoxycarbonylamino-phenyl ester
  参考文献：
  名称：

  Carbazates as potent inhibitors of hormone-sensitive lipase

  摘要：

  The central role of adipose tissue hormone-sensitive lipase in regulating fatty acid metabolism makes it a potential pharmacological target for the prevention of peripheral insulin resistance in obese, prediabetic and diabetic individuals. The synthesis of a new series of carbazates is presented. Modification of the phenolic 4-position in a series of 1,2,3,4-tetrahydroisoquinoline and morpholine derived carbazates, yielded inhibitors of the catalytic activity of this enzyme with nanomolar potency. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.01.038

文献信息

• [EN] COMPOUNDS FOR TREATING DISORDERS WHERE A DECREASED LEVEL OF PLASMA FFA IS DESIRED<br/>[FR] COMPOSES DESTINES AU TRAITEMENT DE TROUBLES DANS LESQUELS UNE DIMINUTION DU NIVEAU D'AGL DU PLASMA EST VOULUE
  申请人：NOVO NORDISK AS

  公开号：WO2001087843A1

  公开（公告）日：2001-11-22

  The present invention relates to novel compounds of general formula (I), wherein A is a nitrogen containing ring systen attached through the nitrogen atom, compositions containing them, and their use for treating medical disorders where a decreased level of plasma free fatty acids (FFA) is desired.
• Compounds for treating disorders where a decreased level of plasma FFA is desired
  申请人：——

  公开号：US20020082254A1

  公开（公告）日：2002-06-27

  The present invention relates to novel compounds, compositions containing them, and their use for treating medical disorders where a decreased level of plasma free fatty acids (FFA) is desired.

  这项发明涉及新化合物、含有这些化合物的组合物，以及它们用于治疗需要降低血浆游离脂肪酸（FFA）水平的医学疾病的用途。
• Carbazates as potent inhibitors of hormone-sensitive lipase
  作者：Johannes C. de Jong、Lotte G. Sørensen、Hans Tornqvist、Poul Jacobsen

  DOI：10.1016/j.bmcl.2004.01.038

  日期：2004.4

  The central role of adipose tissue hormone-sensitive lipase in regulating fatty acid metabolism makes it a potential pharmacological target for the prevention of peripheral insulin resistance in obese, prediabetic and diabetic individuals. The synthesis of a new series of carbazates is presented. Modification of the phenolic 4-position in a series of 1,2,3,4-tetrahydroisoquinoline and morpholine derived carbazates, yielded inhibitors of the catalytic activity of this enzyme with nanomolar potency. (C) 2004 Elsevier Ltd. All rights reserved.