(3RS)-N-benzyl-3,4-epoxybutanamide | 131653-41-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3RS)-N-benzyl-3,4-epoxybutanamide
• 英文别名: N-benzyl-2-(oxiran-2-yl)acetamide
• CAS: 131653-41-3
• 化学式: C₁₁H₁₃NO₂
• 分子量: 191.23
• InChiKey: INPVFMLVFIROAO-UHFFFAOYSA-N

物化性质

• 沸点：
  413.3±28.0 °C(Predicted)
• 密度：
  1.158±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (3RS)-N-benzyl-3,4-epoxybutanamide 在 IRA 900 with methoxy anion 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以73%的产率得到N-benzyl-4-hydroxybut-2-enamide
  参考文献：
  名称：

  Conjugate intra- and intermolecular addition mediated by methoxide anion on polymeric support

  摘要：

  By treatment with methoxide anion on polymeric support (IRA 900), chiral beta -oxo or beta -sulphonylamides 2 bearing an alpha,beta -unsaturated ester gave 3,4-disubstituted pyrrolidin-2-ones 3 as easily separable diastereomeric mixtures in good yield and moderate-to-good stereoselection. The polymeric reagent was also effective in promoting both intermolecular conjugate addition and alkylation reactions. (C) 2000 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(00)01490-8
• 作为产物：
  描述：

  N-benzyl-3-butenamide 在 间氯过氧苯甲酸 作用下， 以 氯仿 为溶剂， 反应 10.0h， 以85%的产率得到(3RS)-N-benzyl-3,4-epoxybutanamide
  参考文献：
  名称：

  Orena, Mario; Porzi, Gianni; Sandri, Sergio, Journal of Chemical Research, Miniprint, 1990, # 11, p. 2701 - 2711

  摘要：

  DOI：

文献信息

• ORENA, MARIO;PORZI, GIANNI;SANDRI, SERGIO
  作者：ORENA, MARIO、PORZI, GIANNI、SANDRI, SERGIO

  DOI：——

  日期：——
• Conjugate intra- and intermolecular addition mediated by methoxide anion on polymeric support
  作者：Cristiana Fava、Roberta Galeazzi、Eugenia Maria Gonzalez-Rosende、Mario Orena

  DOI：10.1016/s0040-4039(00)01490-8

  日期：2000.10

  By treatment with methoxide anion on polymeric support (IRA 900), chiral beta -oxo or beta -sulphonylamides 2 bearing an alpha,beta -unsaturated ester gave 3,4-disubstituted pyrrolidin-2-ones 3 as easily separable diastereomeric mixtures in good yield and moderate-to-good stereoselection. The polymeric reagent was also effective in promoting both intermolecular conjugate addition and alkylation reactions. (C) 2000 Published by Elsevier Science Ltd.
• Orena, Mario; Porzi, Gianni; Sandri, Sergio, Journal of Chemical Research, Miniprint, 1990, # 11, p. 2701 - 2711
  作者：Orena, Mario、Porzi, Gianni、Sandri, Sergio

  DOI：——

  日期：——