3-Benzylidene-6-methoxy-4-chromanone | 1190694-96-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 高异黄酮
• 英文名称: 3-Benzylidene-6-methoxy-4-chromanone
• 英文别名: 3-Benzylidene-6-methoxychroman-4-one；(3E)-3-benzylidene-6-methoxychromen-4-one
• CAS: 1190694-96-2
• 化学式: C₁₇H₁₄O₃
• 分子量: 266.296
• InChiKey: OWATYAZLQOTHEU-UKTHLTGXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-Benzylidene-6-methoxy-4-chromanone 、 L-脯氨酸 、 苊醌 以 甲醇 、 水 为溶剂， 反应 4.0h， 生成
  参考文献：
  名称：

  A facile entry into a novel class of dispiroheterocyclic framework through 1,3-dipolarcycloaddition of azomethine ylides with 3-arylidene-4-chromanones as dipolarophiles

  摘要：

  The cycloaddition reaction of azomethine ylides, generated through decarboxylation, with (E)-3-arylidene-4-chromanones as dipolarophiles has been investigated. A high degree of regioselectivity has been observed in the synthesis of a new class of functionalized dispiroheterocyclic compounds bearing chromanone and acenaphthenequinone framework. The structures were established by spectroscopic techniques as well as single crystal X-ray analysis. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.08.010
• 作为产物：
  描述：

  6-甲氧基-4-二氢色原酮 在 苯甲醛 作用下， 以25.1 g (84%)的产率得到3-Benzylidene-6-methoxy-4-chromanone
  参考文献：
  名称：

  Substituted tetralins, chromans and related compounds in the treatment

  摘要：

  取代四氢萘、环己烷和相关化合物，通过抑制5-脂氧酶酶和/或阻断白三烯受体，在哺乳动物中可用于预防或治疗哮喘、关节炎、牛皮癣、溃疡、心肌梗死及相关疾病状态的药物组合物，以及用于治疗的方法，以及用于合成的中间体。

  公开号：

  US05059609A1

文献信息

• Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
  申请人：PFIZER INC.

  公开号：EP0313295A2

  公开（公告）日：1989-04-26

  Substituted tetralins, chromans and related compounds which, by inhibiting 5-lipoxygenase enzyme and/or blocking leukotriene receptors, are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related disease states in mammals, pharmaceutical compositions thereof, and intermediates useful in the synthesis thereof.

  通过抑制 5-脂氧合酶和/或阻断白三烯受体，可用于预防或治疗哺乳动物哮喘、关节炎、牛皮癣、溃疡、心肌梗塞及相关疾病的取代四氢萘类化合物、色喃类化合物及相关化合物、其药物组合物以及用于合成这些化合物的中间体。
• US5059609A
  申请人：——

  公开号：US5059609A

  公开（公告）日：1991-10-22
• US5998451A
  申请人：——

  公开号：US5998451A

  公开（公告）日：1999-12-07
• Substituted tetralins, chromans and related compounds in the treatment
  申请人：Pfizer Inc.

  公开号：US05059609A1

  公开（公告）日：1991-10-22

  Substituted tetralins, chromans and related compounds which, by inhibiting 5-lipoxygenase enzyme and/or blocking leukotriene receptors, are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related disease states in mammals, pharmaceutical compositions thereof, a method of treatment therewith, and to intermediates useful in the synthesis thereof.

  取代四氢萘、环己烷和相关化合物，通过抑制5-脂氧酶酶和/或阻断白三烯受体，在哺乳动物中可用于预防或治疗哮喘、关节炎、牛皮癣、溃疡、心肌梗死及相关疾病状态的药物组合物，以及用于治疗的方法，以及用于合成的中间体。
• A facile entry into a novel class of dispiroheterocyclic framework through 1,3-dipolarcycloaddition of azomethine ylides with 3-arylidene-4-chromanones as dipolarophiles
  作者：T. Augustine、Charles C. Kanakam、Scholastica Mary Vithiya、V. Ramkumar

  DOI：10.1016/j.tetlet.2009.08.010

  日期：2009.10

  The cycloaddition reaction of azomethine ylides, generated through decarboxylation, with (E)-3-arylidene-4-chromanones as dipolarophiles has been investigated. A high degree of regioselectivity has been observed in the synthesis of a new class of functionalized dispiroheterocyclic compounds bearing chromanone and acenaphthenequinone framework. The structures were established by spectroscopic techniques as well as single crystal X-ray analysis. (C) 2009 Elsevier Ltd. All rights reserved.