N-Methyl-N'-(4-acetamino-phenyl)-harnstoff | 7151-79-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-Methyl-N'-(4-acetamino-phenyl)-harnstoff
• 英文别名: N-(4-{[(methylamino)carbonyl]amino}phenyl)acetamide；N-[4-(methylcarbamoylamino)phenyl]acetamide
• CAS: 7151-79-3
• 化学式: C₁₀H₁₃N₃O₂
• mdl: MFCD00091319
• 分子量: 207.232
• InChiKey: DNBNPZMPGGMHEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  70.2
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  异氰酸甲酯 、 4′-氨基乙酰苯胺 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 N-Methyl-N'-(4-acetamino-phenyl)-harnstoff
  参考文献：
  名称：

  抗肿瘤剂的合成。XXXII。N-硝基 一世。

  摘要：

  DOI：

  10.1021/jm00342a010

文献信息

• POLYURETHANE/UREA MATERIALS
  申请人：Commonwealth Scientific and Industrial Research Organisation

  公开号：EP3851469A1

  公开（公告）日：2021-07-21

  The present disclosure provides soft block copolymer segments of Formula 1 for thermoplastic polyurethane or polyurethaneurea elastomer materials and their reaction products with divalent compounds, such as diisocyanates, chain extenders and optional additional polyols or polyamines. Also disclosed herein are methods for the production of the soft block copolymer segments, and possible applications of these materials in the formation of biomaterials for articles including medical devices such as implants, heart valves and drug delivery devices.

  本公开提供了用于热塑性聚氨酯或聚氨酯脲弹性体材料的式 1 的软嵌段共聚物片段及其与二价化合物（如二异氰酸酯）、扩链剂和任选附加多元醇或多胺的反应产物。本文还公开了软嵌段共聚物片段的生产方法，以及这些材料在形成生物材料（包括植入物、心脏瓣膜和给药装置等医疗器械）方面的可能应用。
• EP3368582B1
  申请人：——

  公开号：EP3368582B1

  公开（公告）日：2020-12-30
• POLYURETHANE/UREA COMPOSITIONS
  申请人：Commonwealth Scientific and Industrial Research Organisation

  公开号：US20170119923A1

  公开（公告）日：2017-05-04

  A valve in the form of a medical device, article, or implant that is composed wholly or partly of a biomaterial, the biomaterial comprising a polyurethane or polyurethane urea elastomeric composition having a plurality of soft segments and hard segments, such that the plurality of soft segments are each derived from at least one block copolymer segment of Formula 1 and optionally an additional polyol or polyamine. The valve may include a plurality of valve leaflets and a support structure with one or more of the valve leaflets being composed wholly or partly of the biomaterial.
• [EN] POLYURETHANE/UREA MATERIALS<br/>[FR] MATÉRIAUX DE POLYURÉTHANNE/URÉE
  申请人：COMMW SCIENT IND RES ORG

  公开号：WO2017070743A1

  公开（公告）日：2017-05-04

  The present disclosure provides soft block copolymer segments of Formula 1 for thermoplastic polyurethane or polyurethaneurea elastomer materials and their reaction products with divalent compounds, such as diisocyanates, chain extenders and optional additional polyols or polyamines. Also disclosed herein are methods for the production of the soft block copolymer segments, and possible applications of these materials in the formation of biomaterials for articles including medical devices such as implants, heart valves and drug delivery devices.
• The Synthesis of Antineoplastic Agents. XXXII. N-Nitrosoureas.¹ I.
  作者：Thomas P. Johnston、George S. McCaleb、John A. Montgomery

  DOI：10.1021/jm00342a010

  日期：1963.11