1-Propoxy-3-butoxy-2-propanol | 53146-41-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 1-Propoxy-3-butoxy-2-propanol
• 英文别名: 1-Butoxy-3-propoxypropan-2-ol
• CAS: 53146-41-1
• 化学式: C₁₀H₂₂O₃
• 分子量: 190.283
• InChiKey: PXNYRZBYDKNYAH-UHFFFAOYSA-N

物化性质

• 沸点：
  267.3±25.0 °C(Predicted)
• 密度：
  0.931±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  正丁基缩水甘油醚 、 丙醇 在 硫酸 、 silica gel 作用下， 反应 1.0h， 以94%的产率得到1-Propoxy-3-butoxy-2-propanol
  参考文献：
  名称：

  二氧化硅硫酸；一种高效且可重复使用的催化剂，用于通过酒精和水对环氧化物进行区域选择性开环

  摘要：

  脂肪醇和水对环氧化物的亲核开环反应在催化量的具有高度区域选择性的二氧化硅硫酸的存在下有效地实现。该催化剂可重复使用，可多次使用而不会降低反应产率。

  DOI：

  10.1080/10426500490459722

文献信息

• SILICA SULFURIC ACID; AN EFFICIENT AND REUSABLE CATALYST FOR REGIOSELECTIVE RING OPENING OF EPOXIDES BY ALCOHOLS AND WATER
  作者：Peyman Salehi、Minoo Dabiri、Ali Zolfigol、Ali Bodaghi Fard

  DOI：10.1080/10426500490459722

  日期：2004.6

  The nucleophilic ring opening reactions of epoxides by aliphatic alcohols and water are achieved efficiently in the presence of catalytic amounts of silica sulfuric acid with high degree of regioselectivity. The catalyst is reusable and can be applied several times without any decrease in the yield of reactions.

  脂肪醇和水对环氧化物的亲核开环反应在催化量的具有高度区域选择性的二氧化硅硫酸的存在下有效地实现。该催化剂可重复使用，可多次使用而不会降低反应产率。
• Iron Perchlorate on Silica Gel as Multi-purpose Reagent for Catalysis of Closure and Rupture of Carbon-Oxygen Bond in Epoxides, Alcohols, and Esters
  作者：P. Salechi、M. M. Khodaei、S. B. Ghareghani、A. R. Motlagh

  DOI：10.1023/b:rujo.0000003154.92028.84

  日期：2003.6

  Aliphatic alcohols and water in the presence of catalytic amounts of Fe3+ ion introduced as iron(Ill) perchlorate on silica gel carrier perform efficient regiospecific opening of an epoxy ring. Carbon acids esterification with various type alcohols was carried out using the system Fe(ClO4)(3)-silica gel in dichloromethane under conditions excluding solvolysis. Acetylation and formylation of alcohols was performed by efficient transesterification with ethyl acetate and ethyl formate.
• Magnesium Hydrogensulfate: A Cheap and Efficient Catalyst for the Conversion of Epoxides into β-Alkoxy Alcohols, Vicinal-Diols, and Thiiranes
  作者：Peyman Salehi、Mohammad Mahdi Khodaei、Mohammad Ali Zolfigol、Afsaneh Keyvan

  DOI：10.1081/scc-120022479

  日期：2003.9.1

  The nucleophilic ring opening reactions of epoxides by aliphatic alcohols and water are achieved efficiently in the presence of catalytic amounts of magnesium hydrogensulfate, Mg(HSO4)(2), with high degree of regioselectivity. The reactions are chemoselective and many of the other functional groups such as ethereal carbon-oxygen bonds as well as carbon-carbon double bond remain intact under the reaction conditions. Epoxides also react with thiourea or ammonium thiocyanate in the presence of Mg(HSO4)(2) to afford the corresponding thiiranes in good to excellent yields.
• NUTIU, MARIA;IDITOIU, CORNELIA;DENES, ELISABETA, REV. CHIM., 38,(1987) N 8, 670-673
  作者：NUTIU, MARIA、IDITOIU, CORNELIA、DENES, ELISABETA

  DOI：——

  日期：——
• An Fe 3 O 4 nanoparticle-supported Mn (II)-azo Schiff complex acts as a heterogeneous catalyst in alcoholysis of epoxides
  作者：Fahimeh Karami Olia、Soheil Sayyahi、Narges Taheri

  DOI：10.1016/j.crci.2016.06.007

  日期：2017.4

  Résumé In this paper, an azo-containing Schiff base complex of manganese [Mn2+-azo ligand@APTES-SiO2@Fe3O4] immobilized on chemically modified Fe3O4 nanoparticles has been used as a magnetically retrievable catalyst for the alcoholysis of different epoxides to their corresponding alkoxy alcohols with methanol, ethanol and n-propanol. The newly magnetic nanoparticles (MNPs) were characterized by Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX) and vibrating sample magnetometry (VSM).

  Résumé 本文将固定在化学修饰的 Fe3O4 纳米粒子上的含偶氮的锰希夫碱配合物[Mn2+-偶氮配体@APTES-SiO2@Fe3O4]作为磁性可回收催化剂，用于用甲醇、乙醇和正丙醇将不同的环氧化物醇解为相应的烷氧基醇。傅立叶变换红外光谱（FT-IR）、透射电子显微镜（TEM）、扫描电子显微镜（SEM）、能量色散 X 射线分析（EDX）和振动样品磁强计（VSM）对新的磁性纳米粒子（MNPs）进行了表征。