2-(6-methoxy-2-naphthoyl)-4-methoxybenzoic acid | 67448-86-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(6-methoxy-2-naphthoyl)-4-methoxybenzoic acid
• 英文别名: 2-(6-Methoxy-2-naphthyl)-4-methoxybenzoesaeure；4-Methoxy-2-(6-methoxynaphthalene-2-carbonyl)benzoic acid
• CAS: 67448-86-6
• 化学式: C₂₀H₁₆O₅
• 分子量: 336.344
• InChiKey: ZVXGDCKSLDFBDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(6-methoxy-2-naphthoyl)-4-methoxybenzoic acid 生成 3,9-dimethoxy-7-methylbenzanthr-12-one
  参考文献：
  名称：

  MORREAL, C. E.;SINHA, D. K.;SCHNEIDER, S. L.;BRONSTEIN, R. E.;DAWIDZIK, J+, J. MED. CHEM., 1982, 25, N 3, 323-326

  摘要：

  DOI：

文献信息

• MORREAL C. E.; BRONSTEIN R. E., J. CHEM. AND ENG. DATA, 1978, 23, NO 4, 354-356
  作者：MORREAL C. E.、 BRONSTEIN R. E.

  DOI：——

  日期：——
• Antiestrogenic properties of substituted benz[a]anthracene-3,9-diols
  作者：Charles E. Morreal、Dilip K. Sinha、Sara L. Schneider、Robert E. Bronstein、Jean Dawidzik

  DOI：10.1021/jm00345a018

  日期：1982.3

  The antiestrogenic potency of benz[a]anthracene-3,9-diol, as well as its 7- and 12-methyl derivatives, was evaluated by measuring he inhibition in the onset of estrus brought about by this compound in ovariectomized rats treated with 17beta-estradiol. At a dose of 0.5 mg and 7,12-dimethyl derivative caused a decrease in the percentage of rats in estrus from 78 to 44%. This decrease is identical with that caused by 0.05 mg of nafoxidine.