2-hydroxy-3-ethyl-5,6-dimethyl-pyrazine | 68808-16-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-hydroxy-3-ethyl-5,6-dimethyl-pyrazine
• 英文别名: 3-ethyl-5,6-dimethyl-1H-pyrazin-2-one
• CAS: 68808-16-2
• 化学式: C₈H₁₂N₂O
• 分子量: 152.196
• InChiKey: JLQKQIUTUSRDNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-hydroxy-3-ethyl-5,6-dimethyl-pyrazine 在 三氯氧磷 作用下， 生成 2-ethyl-3-chloro-5,6-dimethyl-pyrazine
  参考文献：
  名称：

  The Preparation of Hydroxypyrazines and Derived Chloropyrazines

  摘要：

  DOI：

  10.1021/ja01126a070
• 作为产物：
  描述：

  2,3-丁二酮 、 alkaline earth salt of/the/ methylsulfuric acid 在 甲醇 、 sodium hydroxide 作用下， 生成 2-hydroxy-3-ethyl-5,6-dimethyl-pyrazine
  参考文献：
  名称：

  The Preparation of Hydroxypyrazines and Derived Chloropyrazines

  摘要：

  DOI：

  10.1021/ja01126a070

文献信息

• 1-substituted alkyl-1,2-dihydro-2-pyrazinone derivatives
  申请人：Toyo Jozo Kabushiki Kaisha

  公开号：US04837319A1

  公开（公告）日：1989-06-06

  1-Substituted alkyl-1,2-dihydro-2-pyrazinone derivatives of the formula ##STR1## wherein A is lower alkyl; R.sub.1 is selected from the group consisting of alkyl, phenyl-lower alkyl, and substituted phenyl-lower alkyl; R.sub.2 and R.sub.3 are each lower alkyl, or together form tetramethylene and R is selected from the group consisting of hydroxyl, hologen, lower alkanoyloxy R.sub.4 -carbamoyloxy, arylthio, 1-methyltetrazole-5-yl-thio, 1-imidazole, morpholino, ##STR2## in which R.sub.4 is lower alkyl or aryl, R.sub.5 is lhydrogen, lower alkyl or aryl, R.sub.6 is hydrogen, lower alkyl, hydroxy-lower alkyl, aryl, aryl-lower alkanoyl, arylcarbonyl, arylsulfonyl or thienyl-lower alkanoyl, Ar is phenyl or phenyl substituted with C.sub.1-3 alkyl, halogen, nitro, or lower alkoxy, A, R.sub.1, R.sub.2 and R.sub.3 are as defined above, m is an integer from 4-6, and n is 2 or 3; and pharmaceutically acceptable salts thereof. The compounds are useful as agents for platelet aggregation inhibition, vasodilation and anti-lipoperoxide generation.

  式子如下：##STR1## 其中A是低碳基；R.sub.1选自烷基、苯基-低碳基、取代苯基-低碳基；R.sub.2和R.sub.3分别是低碳基，或者一起形成四亚甲基，R选自羟基、卤素、低碳酰氧基、R.sub.4-氨基甲酰氧基、芳基硫醇、1-甲基四唑-5-基硫醇、1-咪唑、吗啉基、##STR2## 其中R.sub.4是低碳基或芳基，R.sub.5是氢、低碳基或芳基，R.sub.6是氢、低碳基、羟基-低碳基、芳基、芳基-低碳酰基、芳基羰基、芳基磺酰基或噻吩基-低碳酰基，Ar是苯基或取代了C.sub.1-3烷基、卤素、硝基或低碳氧基的苯基，其中A、R.sub.1、R.sub.2和R.sub.3如上所定义，m是4-6的整数，n为2或3；以及其药学上可接受的盐。这些化合物可用作抑制血小板聚集、扩张血管和抗脂质过氧化物生成的药物。
• 1-Substituted alkyl-1,2-dihydro-2-pyrazinone derivatives
  申请人：Toyo Jozo Kabushiki Kaisha

  公开号：US04870176A1

  公开（公告）日：1989-09-26

  1-Substituted alkyl-1,2-dihydro-2-pyrazinone derivatives of the formula ##STR1## wherein A is lower alkylene; R.sub.1 is selected from the group consisting of alkyl, phenyl-lower alkyl, and substituted phenyl-lower alkyl; R.sub.2 and R.sub.3 are each lower alkyl; and R is selected from the group consisting of hydroxyl, halogen, lower alkanoyloxy, R.sub.4 -carbamoyloxy and arylthio, in which R.sub.4 is lower alkyl or aryl; and pharmaceutically acceptable salts thereof. The compounds are useful as agents for platelet aggregation inhibition, vasodilation and anti-lipoperoxide generation.

  公式为##STR1##的1-取代烷基-1,2-二氢-2-吡嗪酮衍生物，其中A为低碳链；R.sub.1选自烷基、苯基-低碳基、和取代苯基-低碳基；R.sub.2和R.sub.3分别为低碳基；R选自羟基、卤素、低碳酰氧基、R.sub.4-氨基甲酸酯氧基和芳基硫基，其中R.sub.4为低碳基或芳基；以及其药学上可接受的盐。这些化合物可用作血小板聚集抑制剂、血管扩张剂和抗脂质过氧化生成剂。
• 1-substituted alkyl-2-oxo-hexahydroquinoxaline derivatives
  申请人：Toyo Jozo Kabushiki Kaisha

  公开号：US04877877A1

  公开（公告）日：1989-10-31

  1-Substituted alkyl-2-oxo-hexahydroquinoxaline derivatives of the formula ##STR1## wherein A is lower alkylene; R.sub.1 is selected from the group consisting of alkyl, phenyl-lower alkyl, and substituted phenyl-lower alkyl; and R is selected from the group consisting of hydroxyl, halogen, lower alkanocyloxy, R.sub.4 -carbamoyloxy and arylthio, in which R.sub.4 is lower alkyl or aryl; and pharmaceutically acceptable salts thereof. The compounds are useful as agents for platelet aggregation inhibition, vasodilation and anti-lipoperoxide generation.

  该文献描述了式子##STR1##的1-取代烷基-2-氧代-六氢喹诺啉衍生物，其中A是低碳链烷基；R.sub.1选自烷基、苯基-低碳链烷基和取代苯基-低碳链烷基；R选自羟基、卤素、低碳酰氧基、R.sub.4-氨基甲酸酯氧基和芳基硫醚，其中R.sub.4是低碳链烷基或芳基；以及其药学上可接受的盐。这些化合物可用作抑制血小板聚集、扩张血管和抗脂质过氧化产生的剂。
• 1-Substituted alkyl-2-oxo-hexahydroquinoxaline derivatives
  申请人：Toyo Jozo Kabushiki Kaisha

  公开号：US04877875A1

  公开（公告）日：1989-10-31

  1-Substituted alkyl-2-oxo-hexahydroquinoxaline derivatives of the formula ##STR1## wherein A is lower alkylene; R.sub.1 is selected from the group consisting of alkyl, phenyl-lower alkyl, and substituted phenyl-lower alkyl; and R is selected from the group consisting of 1-methyltetrazole-5-yl-thio, 1-imidazolyl, morpholino, ##STR2## in which R.sub.5 is hydrogen, lower alkyl or aryl, R.sub.6 is hydrogen, lower alkyl, hydroxy-lower alkyl, aryl, aryl-lower alkanoyl, arylcarbonyl, arylsulfonyl or thienyl-lower alkanoyl, Ar is phenyl or phenyl substituted with C.sub.1-3 alkyl, halogen, nitro, or lower alkoxy, A and R.sub.1 are as defined above, R.sub.2 and R.sub.3 are each lower alkyl or together form tetramethylene, m is an integer from 4-6, and n is 2 or 3; and pharmaceutically acceptable salts thereof. The compounds are useful as agents for platelet aggregation inhibition, vasodilation and anti-lipoperoxide generation.

  公式为##STR1##的1-取代烷基-2-氧代六氢喹喔啉衍生物，其中A为低碳烷基；R.sub.1选自烷基、苯基-低碳烷基和取代苯基-低碳烷基的群；R选自1-甲基四氮唑-5-基硫、1-咪唑基、吗啉、##STR2## 其中R.sub.5为氢、低碳烷基或芳基，R.sub.6为氢、低碳烷基、羟基-低碳烷基、芳基、芳基-低碳酰基、芳基羰基、芳基磺酰基或噻吩基-低碳酰基，Ar为苯基或取代有C.sub.1-3烷基、卤素、硝基或低碳烷氧基的苯基，A和R.sub.1如上定义，R.sub.2和R.sub.3各自为低碳烷基或一起形成四亚甲基，m为4-6的整数，n为2或3；以及其药学上可接受的盐。该化合物可用作抑制血小板聚集、扩张血管和抗脂质过氧化物生成的剂。
• YASO, MASSO;SUZUKI, YUKIO;SHIBATA, KENSUKE;HAYASHI, EIICHI
  作者：YASO, MASSO、SUZUKI, YUKIO、SHIBATA, KENSUKE、HAYASHI, EIICHI

  DOI：——

  日期：——