4-(3-fluorophenyl)-2-methylpyrimidine | 85979-50-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-(3-fluorophenyl)-2-methylpyrimidine
• CAS: 85979-50-6
• 化学式: C₁₁H₉FN₂
• 分子量: 188.204
• InChiKey: JPFCNAIVBQDQBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  sodium;(E)-3-(3-fluorophenyl)-3-oxoprop-1-en-1-olate 、 乙脒碱 以41%的产率得到
  参考文献：
  名称：

  BARAM, S. G.;SHKURKO, O. P.;MAMAEV, V. P., IZV. CO AN CCCP. CEP. XIM. N., 1983, N 4/2, 111-117

  摘要：

  DOI：

文献信息

• PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES
  申请人：Aissaoui Hamed

  公开号：US20110212968A1

  公开（公告）日：2011-09-01

  The invention relates to novel phenethylamide derivatives and their wherein A, B, R 1 , R 2 and R 3 are as described in the application, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.

  本发明涉及新型苯乙酰胺衍生物及其其中A、B、R1、R2和R3如本申请中所述的衍生物的药物学上可接受的盐的使用，特别是作为药物，尤其是作为促进睡眠的药物，如促进睡眠的药物。
• 1-cyano-pyrrolidine compounds as USP30 inhibitors
  申请人：Mission Therapeutics Limited

  公开号：US10689345B2

  公开（公告）日：2020-06-23

  The present invention relates to novel compounds and method for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 30 (USP30). The invention further relates to the use of DUB inhibitors in the treatment of conditions involving mitochondrial dysfunction and cancer. Compounds of the invention include compounds having the formula (II) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R8, R9, R10, R12, Z, Y and m are as defined herein.

  本发明涉及新型化合物和去泛素化酶（DUB）抑制剂的制造方法。特别是，本发明涉及泛素 C 端水解酶 30（USP30）的抑制。本发明还涉及 DUB 抑制剂在治疗线粒体功能障碍和癌症方面的用途。本发明的化合物包括具有式(II)的化合物或其药学上可接受的盐，其中R1、R2、R3、R4、R5、R8、R9、R10、R12、Z、Y和m如本文所定义。
• Synthesis of 4-Aryl and Unsymmetrical 4,6-Diarylpyrimidines by the Suzuki-Miyaura Cross-Coupling Reaction
  作者：Victor Snieckus、Gerald J. Tanoury、Sahaj Gupta、Jennifer A. Melanson、M Selim Hossain、Louis Vaillancourt、William A. Nugent

  DOI：10.3987/com-18-13956

  日期：——

  A two-step procedure for the synthesis of 4-arylpyrimidines from inexpensive 4,6-dichloropyrimidine via a Suzuki-Miyaura/hydrodechlorination reaction sequence is described. The reaction resulted in the predominant formation of mono-arylated product. The cross-coupling of 4-chloro-6-substituted pyrimidines with various aryl/heteroarylboronic acids also furnished 4,6-disubstituted pyrimidines in acceptable yields.
• 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS
  申请人：Mission Therapeutics Limited

  公开号：EP3277677B9

  公开（公告）日：2021-07-14
• BARAM, S. G.;SHKURKO, O. P.;MAMAEV, V. P., IZV. CO AN CCCP. CEP. XIM. N., 1983, N 4/2, 111-117
  作者：BARAM, S. G.、SHKURKO, O. P.、MAMAEV, V. P.

  DOI：——

  日期：——