1,3,7-Trihydroxy-anthrachinon | 26131-14-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 1,3,7-Trihydroxy-anthrachinon
• 英文别名: 1,3,7-trihydroxy-anthraquinone；1,3,7-Trihydroxyanthracene-9,10-dione
• CAS: 26131-14-6
• 化学式: C₁₄H₈O₅
• 分子量: 256.215
• InChiKey: WXKSERWQCRFOBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1,3,7-Trihydroxy-anthrachinon 、 乙酸酐 以74%的产率得到
  参考文献：
  名称：

  CAMERON D. W.; CROSSLEY M. J.; FEUTRILL G. I.; GRIFFITHS P. G., AUSTRAL. J. CHEM., 1978, 31, NO 6, 1335-1352

  摘要：

  DOI：
• 作为产物：
  描述：

  1.3.7-Triethoxyanthrachinon 以94%的产率得到
  参考文献：
  名称：

  CAMERON D. W.; CROSSLEY M. J.; FEUTRILL G. I.; GRIFFITHS P. G., AUSTRAL. J. CHEM., 1978, 31, NO 6, 1335-1352

  摘要：

  DOI：

文献信息

• Formulation and process for modulating wound healing
  申请人：BioMendics, LLC

  公开号：US10426742B2

  公开（公告）日：2019-10-01

  Methods and compounds are disclosed for wound healing by modulating autophagy. A formulation for modulating autophagy comprises a first modulating compound (FAM) selected from compounds having the general structure (I): wherein: L represents a linker selected from —C≡C—, (a tolan), —CH═CH— (a stilbene, preferably trans); or —CRa═CRb— a stilbene derivative; where Ra and Rb are independently H or phenyl optionally substituted with —(R3)p or —(R4)q; R1 to R4 are independent substituents at any available position of the phenyl rings, preferably at 3, 3′, 4, 4′, and/or 5, 5′; and m, n, p, and q are independently 0, 1, 2, or 3 representing the number of substituents of the rings, respectively, but at least one of m or n must be ≥1. Each R1 to R2 is independently selected from substituents described herein, including but not limited to hydroxyl, alkoxy, halo, halomethyl and glycosides. The formulation may also include an auxiliary autophagy modulating compound (AAM) as described herein. The formulation may include a hydrogel formed by the compounds themselves or otherwise and may include salts and/or complexes.

  本发明公开了通过调节自噬促进伤口愈合的方法和化合物。用于调节自噬的制剂包括选自具有一般结构 (I) 的化合物的第一调节化合物 (FAM)： 其中L 代表选自-C≡C-（甲苯）、-CH═CH-（二苯乙烯，最好是反式）或-CRa═CRb-二苯乙烯衍生物的连接体；其中 Ra 和 Rb 独立地是 H 或任选被-(R3)p 或-(R4)q 取代的苯基； R1至R4是独立的取代基，位于苯基环的任何可用位置，优选位于3，3′、4，4′和/或5，5′；m、n、p和q分别独立地为0、1、2或3，代表环的取代基数目，但m或n中至少有一个必须≥1。每个 R1 至 R2 独立地选自本文所述的取代基，包括但不限于羟基、烷氧基、卤代、卤代甲基和苷。制剂还可包括本文所述的辅助自噬调节化合物（AAM）。制剂可包括由化合物本身或以其它方式形成的水凝胶，并可包括盐和/或复合物。
• Parkash; Venkataraman, Journal Of Scientific and Industrial Research, 1954, vol. 13 B, p. 825,828
  作者：Parkash、Venkataraman

  DOI：——

  日期：——
• FORMULATION AND PROCESS FOR MODULATING WOUND HEALING
  申请人：Biomendics LLC

  公开号：EP3280402A2

  公开（公告）日：2018-02-14
• Formulation and Process for Modulating Wound Healing
  申请人：BioMendics, LLC

  公开号：US20160296477A1

  公开（公告）日：2016-10-13

  Methods and compounds are disclosed for wound healing by modulating autophagy. A formulation for modulating autophagy comprises a first modulating compound (FAM) selected from compounds having the general structure (I): wherein: L represents a linker selected from —C≡C—, (a tolan), —CH═CH— (a stilbene, preferably trans); or —CR a ═CR b — a stilbene derivative; where R a and R b are independently H or phenyl optionally substituted with —(R 3 ) p or —(R 4 ) q ; R 1 to R 4 are independent substituents at any available position of the phenyl rings, preferably at 3, 3′, 4, 4′, and/or 5, 5′; and m, n, p, and q are independently 0, 1, 2, or 3 representing the number of substituents of the rings, respectively, but at least one of m or n must be ≧1. Each R 1 to R 2 is independently selected from substituents described herein, including but not limited to hydroxyl, alkoxy, halo, halomethyl and glycosides. The formulation may also include an auxiliary autophagy modulating compound (AAM) as described herein. The formulation may include a hydrogel formed by the compounds themselves or otherwise and may include salts and/or complexes.
• [EN] FORMULATION AND PROCESS FOR MODULATING WOUND HEALING<br/>[FR] FORMULATION ET PROCÉDÉ PERMETTANT DE MODULER LA CICATRISATION DE PLAIE
  申请人：BIOMENDICS LLC

  公开号：WO2016164531A2

  公开（公告）日：2016-10-13

  Methods and compounds are disclosed for wound healing by modulating autophagy. A formulation for modulating autophagy comprises a first modulating compound (FAM) selected from compounds having the general structure (I) wherein: L represents a linker selected from -C≡C-, (a tolan), -CH=CH- (a stilbene, preferably trans); or -CRa=CRb- a stilbene derivative; where Ra and Rb are independently H or phenyl optionally substituted with -(R3)p or -(R4)q; R1 to R4 are independent substituents at any available position of the phenyl rings, preferably at 3, 3', 4, 4', and/or 5, 5'; and m, n, p, and q are independently 0, 1, 2, or 3 representing the number of substituents of the rings, respectively, but at least one of m or n must be ≥1. Each R1 to R2 is independently selected from substituents described herein, including but not limited to hydroxyl, alkoxy, halo, halomethyl and glycosides. The formulation may also include an auxiliary autophagy modulating compound (AAM) as described herein. The formulation may include a hydrogel formed by the compounds themselves or otherwise and may include salts and/or complexes.