2,3-Dipyridylamin-3-carboxyamid | 68671-72-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,3-Dipyridylamin-3-carboxyamid
• 英文别名: 2-pyridin-3-ylamino-nicotinamide；2-(3-Pyridinylamino)-3-pyridinecarboxamide；2-(pyridin-3-ylamino)pyridine-3-carboxamide
• CAS: 68671-72-7
• 化学式: C₁₁H₁₀N₄O
• 分子量: 214.227
• InChiKey: BLZNUQJALXMKSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  80.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,3'-Dipyridylamino-3-carbonsaeure 以75%的产率得到
  参考文献：
  名称：

  CZUBA W.; BAJGROWICZ J. A., POL. J. CHEM., 1978, 52, NO 7-8, 1395-1402

  摘要：

  DOI：

文献信息

• BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS
  申请人：Portola Pharmaceuticals, Inc.

  公开号：EP2635556A2

  公开（公告）日：2013-09-11
• [EN] BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS<br/>[FR] BENZAMIDES ET NICOTINAMIDES EN TANT QUE MODULATEURS DE SYK
  申请人：PORTOLA PHARM INC

  公开号：WO2012061418A2

  公开（公告）日：2012-05-10

  The present invention is directed to compounds of formula I and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as Non Hodgkin's Lymphoma.
• CZUBA W.; BAJGROWICZ J. A., POL. J. CHEM., 1978, 52, NO 7-8, 1395-1402
  作者：CZUBA W.、 BAJGROWICZ J. A.

  DOI：——

  日期：——