3,4,4-三甲基恶唑烷 | 75673-43-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 中文名称: 3,4,4-三甲基恶唑烷
• 英文名称: 3,4,4-Trimethyloxazolidine
• 英文别名: 3,4,4-trimethyl-1,3-oxazolidine
• CAS: 75673-43-7
• 化学式: C₆H₁₃NO
• 分子量: 115.17
• InChiKey: VJMGCRKBPXGKAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险等级：
  3.2
• 包装等级：
  III
• 危险类别：
  3.2

文献信息

• Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：US20150231142A1

  公开（公告）日：2015-08-20

  The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

  本发明涉及含有上皮钠通道活性抑制剂与至少一种ABC转运蛋白调节剂化合物（A式、B式、C式或D式）的药物组合物。该发明还涉及这些药物配方，以及使用这些组合物治疗CFTR介导的疾病，特别是囊性纤维化的方法。
• COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES
  申请人：Van Goor Fredrick F.

  公开号：US20110098311A1

  公开（公告）日：2011-04-28

  The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

  本发明涉及包含上皮钠通道活性抑制剂与至少一种ABC转运蛋白调节剂化合物（A式、B式、C式或D式）的药物组合物。该发明还涉及这些药物配方，以及使用这些组合物治疗CFTR介导的疾病，特别是囊性纤维化的方法。
• Modulators of ATP-binding cassette transporters
  申请人：Hadida Ruah S. Sara

  公开号：US20080009524A1

  公开（公告）日：2008-01-10

  Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

  本发明的化合物及其药学上可接受的组合物，可用作调节ATP结合盒（“ABC”）转运蛋白或其片段的工具，包括囊性纤维化跨膜传导调节蛋白（“CFTR”）。本发明还涉及使用本发明的化合物治疗ABC转运蛋白介导的疾病的方法。
• Alkoxy disulfides as antimicrobial agents
  申请人：ROHM AND HAAS COMPANY

  公开号：EP1008296A1

  公开（公告）日：2000-06-14

  Disclosed is a method of inhibiting the growth of microorganisms in, at, or on a locus subject to microbial attack, comprising introducing to said locus an antimicrobially effective amount of at least one alkoxy disulfide of formula:R1-CHR3-O-S-S-O-CHR4-R2 wherein: R1, R2are independently selected from 5- or 6-membered aromatic rings, optionally substituted with up to 3 e· donating substituents of which 2 can optionally be combined to form another ring; and R3, R4are independently selected from H, CH3, or CH2CH3.

  揭示了一种抑制微生物在受微生物攻击的位置生长的方法，包括向该位置引入至少一种符合以下式的烷氧基二硫化物的抗微生物有效量：R1-CHR3-O-S-S-O-CHR4-R2其中：R1，R2分别选自5-或6-成员芳香环，可选择地取代多达3个e·供体取代基，其中2个可选择地结合形成另一个环；而R3，R4分别选自H，CH3或CH2 。
• Two part polyurethane sealant composition with low modulus and good paintability
  申请人：Construction Research & Technology GmbH

  公开号：US20040198900A1

  公开（公告）日：2004-10-07

  A polyurethane sealant is the reaction product of a hydroxy-terminated toluenediisocyanate/polyoxyalkylene polyol prepolymer component, an isocyanate-terminated toluenediisocyanate/polyoxyalkylene polyol activator component, and at least one of a diphenylmethane diisocyanate prepolymer component and a diphenylmethane diisocyanate monomer component. A method for making a sealant including providing a base component containing a hydroxy-terminated toluenediisocyanate/polyoxyalkylene polyol prepolymer, an activator component containing an isocyanate-terminated toluenediisocyanate/polyoxyalkylene polyol, and a modifier component containing at least one of a diphenylmethane diisocyanate prepolymer and a diphenylmethane diisocyanate monomer, and combining the base component, activator component, and modifier component to form a polyurethane reaction product.

  聚氨酯密封胶是羟基端苯二异氰酸酯/聚氧烷基聚醚预聚物组分、异氰酸酯端苯二异氰酸酯/聚氧烷基聚醚活化剂组分，以及二苯甲酮二异氰酸酯预聚物组分和二苯甲酮二异氰酸酯单体组分中的至少一种的反应产物。一种制备密封胶的方法包括提供一个基础组分，其中包含羟基端苯二异氰酸酯/聚氧烷基聚醚预聚物，一个活化剂组分，其中包含异氰酸酯端苯二异氰酸酯/聚氧烷基聚醚，以及一个修饰剂组分，其中至少包含二苯甲酮二异氰酸酯预聚物和二苯甲酮二异氰酸酯单体，然后将基础组分、活化剂组分和修饰剂组分结合起来形成聚氨酯反应产物。