(+/-)-4,4',6,6'-tetrachlorodiphenic acid | 31330-25-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (+/-)-4,4',6,6'-tetrachlorodiphenic acid
• 英文别名: (+)-4,4',6,6'-tetrachlorodiphenic acid；(-)-4,4',6,6'-tetrachlorodiphenic acid；(+/-)-4,6,4',6'-tetrachloro-diphenic acid；(+/-)-4,6,4',6'-Tetrachlor-diphensaeure；4.6.4'.6'-Tetrachlor-diphensaeure；2-(2-Carboxy-4,6-dichlorophenyl)-3,5-dichlorobenzoic acid
• CAS: 31330-25-3；32725-88-5；94665-82-4
• 化学式: C₁₄H₆Cl₄O₄
• 分子量: 380.011
• InChiKey: FIUIHIPSDDZKQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (+/-)-4,4',6,6'-tetrachlorodiphenic acid 在 lithium aluminium tetrahydride 、 氯化亚砜 、 三乙胺 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 3.0h， 生成 (+)-4,4',6,6'-tetrachloro-2,2'-bis(methanesulfonatomethyl)-1,1'-biphenyl
  参考文献：
  名称：

  水溶性金属配合物和催化剂：X. BIPHLOPHOS，新型轴向手性二膦配体：苯乙烯的不对称铑催化加氢甲酰化反应的制备和应用

  摘要：

  从容易获得的新的轴向手性二膦配体2,2'-双（二苯基膦甲基）-4,4'，6,6'-四氯-1,1'-联苯5的对映异构体的立体定向合成，从易于获得开发了4,4'，6,6'-四氯二苯甲酸的纯对映体。然后在苯乙烯的均相铑催化的不对称加氢甲酰化反应中测试了（-）-对映体。用该配体制备配合物IrH（CO）（PPh 3）L 2（L 2 = 5）6，确定其晶体结构并与相关配合物RhH（CO）（PPh 3）（BISBI）进行比较。 。另外，配体5用经典方法将其磺化，得到均匀的反应产物。这与类似的配体BISBI和NAPHOS形成鲜明对比，后者的磺化作用会生成复杂的产物混合物。磺化的配体具有极好的水溶性，与经过充分研究的配体BISBI相比，在苯乙烯的加氢甲酰化中显示出活性和区域选择性。

  DOI：

  10.1016/s0022-328x(99)00036-4
• 作为产物：
  描述：

  2-氨基-3,5-二氯苯甲酸 在 盐酸 、 sodium hydroxide 、 sodium nitrite 作用下， 生成 (+/-)-4,4',6,6'-tetrachlorodiphenic acid
  参考文献：
  名称：

  Symmetrical Biaryls from Diazotized Amines. Scope of the Reaction. Unsymmetrical Biaryls

  摘要：

  DOI：

  10.1021/ja01225a035

文献信息

• 新規ビフェニル誘導体および製造方法ならびに光学活性な新規ビフェニル誘導体を用いた光学異性体分離法
  申请人：——

  公开号：JP2000080065A

  公开（公告）日：2000-03-21

  (57)【要約】\n【課題】 多くの光学異性体混合物の光学分割に適用できる新規なビフェニル誘導体の提供\n【解決手段】 式（Ｉ）で表されるビフェニル誘導体及びその製造方法、式（Ｉ）で表される光学活性なビフェニル誘導体及びその製造方法、並びにこの光学活性なビフェニル誘導体を用い、光学異性体混合物を光学分割することを特徴とする光学異性体分離法。\n【化１】\n（式中、X は炭素数５〜７のシクロアルキル基を示す。）

  (57) [摘要] n [问题] 提供一种适用于多种光学异构体混合物的光学分解的新型联苯衍生物。 n [解决方案] 一种由式（I）表示的联苯衍生物及其生产方法，一种由式（I）表示的光学活性联苯衍生物及其生产方法，以及这种光学活性联苯衍生物和一种光学异构体分离方法，其特征在于光学异构体混合物的光学分裂。\Ϯn [Ϯ1] Ϯn（式中，X 表示具有 5 至 7 个碳原子的环烷基）。
• Neises,B.; Steglich,W., Angewandte Chemie, 1978, vol. 90, p. 556 - 557
  作者：Neises,B.、Steglich,W.

  DOI：——

  日期：——
• Correlates of self-perceptions of spirituality in American adults
  作者：Leila Shahabi、Lynda H. Powell、Marc A. Musick、Kenneth I. Pargament、Carl E. Thoresen、David Williams、Lynn Underwood、Marcia A. Ory

  DOI：10.1207/s15324796abm2401_07

  日期：2002.2

  To advance knowledge in the study, of spirituality and physical health, we examined sociodemographic, behavioral, and attitudinal correlates of self-perceptions of spirituality. Participants were a nationally representative sample of 7,422 adult respondents to the 1998 General Social Survey. The), were asked, among other things, to rate themselves on the depth of their spirituality and the depth of their religiousness. Results indicated that, after adjustment for religiousness, self-perceptions of spirituality were positively correlated with beingfemale (r = .07, p < .01), having a higher education (r =. 12, p < .001), and having no religion (r =. 10, p < .001) and inversely correlated with age (r = -.06, p < .05) and being Catholic (r = -.08, p < .01). After adjustment for these sociodeinographic factors, self-perceptions of spirituality were associated with high levels of religious or spiritual activities (range in cot-relations = .12-38, all p < .001), low cynical mistrust, and low political conservatism (both r = -.08, p < .01). The population was divided into 4 groups based on their self-perceptions of degree of spirituality and degree of religiousness. The spiritual and religious group had a higher frequency of attending services, praying, meditating, reading the Bible, and daily spiritual experience than any of the other 3 groups (all differences p < .05) and had less distress and less mistrust than the religious-only group (p < .05 for both). However, they were also more intolerant than either of the nonreligious groups (p < .05 for both) and similar on intolerance to the religious-only group. We conclude that sociodemographic factors could confound any observed association between spirituality and health and should be controlled. Moreover, individuals who perceive themselves to be both spiritual and religious may be at particularly low risk for morbidity and mortality based on their good psychological status and ongoing restorative activities.
• 921. The relation between configuration and conjugation in diphenyl derivatives. Part IX. Some tetrachloro-2 : 2′-bridged compounds
  作者：D. Muriel Hall、Fatima Minhaj

  DOI：10.1039/jr9570004584

  日期：——
• Atkinson; Murphy; Lufkin, Organic syntheses. Collective volume, 1963, vol. IV, p. 872
  作者：Atkinson、Murphy、Lufkin

  DOI：——

  日期：——