6-acetyl-N-(2,6-diethylphenyl)pyridine-2-carboxamide | 1204421-60-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-acetyl-N-(2,6-diethylphenyl)pyridine-2-carboxamide
• CAS: 1204421-60-2
• 化学式: C₁₈H₂₀N₂O₂
• 分子量: 296.369
• InChiKey: CTCTVOGPBNLVPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  59.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,6-二乙基苯胺 、 6-乙酰基-2-吡啶羧酸 反应 0.08h， 以25.5%的产率得到6-acetyl-N-(2,6-diethylphenyl)pyridine-2-carboxamide
  参考文献：
  名称：

  Microwave-Promoted Syntheses of Pyridine Carboxamides and tert-Carboximides from Novel 6-Acetylpyridine-2-carboxylic Acid

  摘要：

  A novel 6-acetylpyridine-2-carboxylic acid (4) was obtained occasionally during the synthesis of asymmetric ethyl 6-acetylpyridine-2-carboxylate (3) from 2,6-dipiclinic acid (1). Compounds 3 and 4 could transform mutually under some specific conditions. Two reactions of distinctive types occurred when they reacted with the aromatic amines as precursors, due to different functional groups on the 2-position of pyridine in the molecules of 3 and 4: one was Schiff base condensation and the other was an amidation reaction. From the latter reaction, two series of new compounds, pyridine carboxamides (5a-d) and pyridine tert-carboximides (6a-h), resulted. The relevant reaction mechanism is discussed in detail.

  DOI：

  10.1080/00397910902906586

文献信息

• Microwave-Promoted Syntheses of Pyridine Carboxamides and <i>tert</i>-Carboximides from Novel 6-Acetylpyridine-2-carboxylic Acid
  作者：Biyun Su、Jianshe Zhao、Qunzheng Zhang、Wenlong Qin

  DOI：10.1080/00397910902906586

  日期：2009.11.18

  A novel 6-acetylpyridine-2-carboxylic acid (4) was obtained occasionally during the synthesis of asymmetric ethyl 6-acetylpyridine-2-carboxylate (3) from 2,6-dipiclinic acid (1). Compounds 3 and 4 could transform mutually under some specific conditions. Two reactions of distinctive types occurred when they reacted with the aromatic amines as precursors, due to different functional groups on the 2-position of pyridine in the molecules of 3 and 4: one was Schiff base condensation and the other was an amidation reaction. From the latter reaction, two series of new compounds, pyridine carboxamides (5a-d) and pyridine tert-carboximides (6a-h), resulted. The relevant reaction mechanism is discussed in detail.