2-Methoxy-5-nitrobenzenesulfonamide | 82020-46-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Methoxy-5-nitrobenzenesulfonamide
• CAS: 82020-46-0
• 化学式: C7H8N2O5S
• mdl: MFCD09737045
• 分子量: 232.22
• InChiKey: DFYMHFOQTWMAFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  124
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-甲氧基-5-硝基苯磺酰氯 、 氨 生成 2-Methoxy-5-nitrobenzenesulfonamide
  参考文献：
  名称：

  MURAMOTO YOSHIHIRO; ASAKURA HIDEYUKI; SUZUKI HITOMI, NIXON KAGAKU KAJSI, NIRRON KAGAKU

  摘要：

  DOI：

文献信息

• 7-MEMBERED RING COMPOUND AND METHOD OF PRODUCTION AND PHARMACEUTICAL APPLICATION THEREOF
  申请人：Muto Tsuyoshi

  公开号：US20090253683A1

  公开（公告）日：2009-10-08

  A 7-membered heterocyclic compound having the formula (I), or its salt, or a solvate thereof with a chymase inhibitory action and useful for the prevention or treatment of various diseases, in which chymase is involved: a method for producing the same, and a pharmaceutical composition useful for the prevention or treatment of diseases, in which chymase is involved, including the compound of having the formula (I), or its pharmaceutically acceptable salt, or a solvate thereof are provided.

  本发明提供一种具有式(I)的7元杂环化合物或其盐或其溶剂合物，具有抑制chymase的作用，用于预防或治疗各种涉及chymase的疾病的方法，以及用于预防或治疗各种涉及chymase的疾病的药物组合物，包括具有式(I)的化合物或其药学上可接受的盐或其溶剂合物的药物组合物。
• 7-membered ring compound and method of production and pharmaceutical application thereof
  申请人：Muto Tsuyoshi

  公开号：US20090111796A1

  公开（公告）日：2009-04-30

  A 7-membered heterocyclic compound having the formula (I), or its salt, or a solvate thereof with a chymase inhibitory action and useful for the prevention or treatment of various diseases, in which chymase is involved: a method for producing the same, and a pharmaceutical composition useful for the prevention or treatment of diseases, in which chymase is involved, including the compound of having the formula (I), or its pharmaceutically acceptable salt, or a solvate thereof are provided.

  提供了一种具有以下公式（I）或其盐或溶剂化物的七元杂环化合物，具有抑制chymase作用，可用于预防或治疗各种涉及chymase的疾病的方法，以及用于预防或治疗这些疾病的制药组合物，包括具有以下公式（I）或其药学上可接受的盐或溶剂化物的化合物。
• Cyclohexyldiamines as selective alpha 1a/1d adrenoreceptor antagonists for the treatment of benign prostatic hypertrophy and lower urinary tract symptoms
  申请人：Chiu George

  公开号：US20060173015A1

  公开（公告）日：2006-08-03

  The present invention relates to compounds of Formula (I) or a pharmaceutically acceptable form thereof, as dual selective α 1a /α 1d adrenoreceptor antagonists for the treatment of benign prostatic hypertrophy and lower urinary tract symptoms. The present invention also relates to pharmaceutical compositions comprising said new compounds, new processes to prepare these new compounds and new uses as a medicine as well as method of treatments.

  本发明涉及式（I）化合物 或其药学上可接受的形式，作为双选择性 α 1a /α 1d 肾上腺素受体拮抗剂，用于治疗良性前列腺肥大和下尿路症状。本发明还涉及包含上述新化合物的药物组合物、制备这些新化合物的新工艺以及作为药物的新用途和治疗方法。
• CYCLOHEXYLDIAMINES AS SELECTIVE ALPHA 1A/1D ADRENORECEPTOR ANTAGONISTS FOR THE TREATMENT OF BENIGN PROSTATIC HYPERTROPHY AND LOWER URINARY TRACT SYMPTOMS
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP1807081A1

  公开（公告）日：2007-07-18
• US7888348B2
  申请人：——

  公开号：US7888348B2

  公开（公告）日：2011-02-15