Benzyl(prop-2-enyl)azanium;chloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzyl(prop-2-enyl)azanium;chloride
• 英文别名: benzyl(prop-2-enyl)azanium;chloride
• 化学式: C10H14ClN
• 分子量: 183.68
• InChiKey: OUDLNGVMJGSNIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.38
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  12
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  苄基叠氮 、 三烯丙基硼烷 、 盐酸 、 sodium hydroxide 以83%的产率得到
  参考文献：
  名称：

  CARBONI, BERTRAND;VAULTIER, MICHEL;COURGEON, THIERRY;CARRIE, ROBERT, BULL. SOC. CHIM. FR.,(1989) N, C. 844-849

  摘要：

  DOI：

文献信息

• [EN] ANTIMICROBIAL COMPOUNDS, THEIR SYNTHESIS AND APPLICATIONS THEREOF<br/>[FR] COMPOSÉS ANTIMICROBIENS, LEUR SYNTHÈSE ET LEURS APPLICATIONS
  申请人：JNCASR BANGALORE

  公开号：WO2014097178A1

  公开（公告）日：2014-06-26

  The present disclosure relates to the field of medicinal chemistry and more particularly to the development of antimicrobial compounds. The disclosure relates to the synthesis and characterization of compounds comprising aromatic radical or an aliphatic radical, an alkyl amine and amino acid moiety wherein said compounds exhibit antimicrobial activity against various drug-sensitive and drug-resistant pathogenic 10 microorganisms.

  本公开涉及药物化学领域，更具体地涉及抗菌化合物的开发。该公开涉及合成和表征包含芳香基团或脂肪基团、烷基胺和氨基酸基团的化合物，其中这些化合物对各种对药物敏感和耐药病原微生物表现出抗菌活性。
• METHOD FOR PRODUCING OPTICALLY ACTIVE N-MONOALKYL-3-HYDROXY-3-ARYLPROPYLAMINE COMPOUND
  申请人：Kogami Kenji

  公开号：US20130005992A1

  公开（公告）日：2013-01-03

  The present invention provides a method for producing an N-monoalkyl-3-hydroxy-3-arylpropylamine compound represented by Formula (2): wherein Ar represents an optionally substituted aryl or an optionally substituted heteroaryl, R represents an optionally substituted C 1-5 alkyl, and * represents an asymmetric carbon atom; the method comprising:reacting, in the presence of an asymmetric reduction catalyst, hydrogen gas with an N-benzyl-N-monoalkyl-3-oxo-3-arylpropenylamine compound represented by Formula (1): wherein Ar and R are as defined above. The present invention allows an optically active N-monoalkyl-3-hydroxy-3-arylpropylamine compound to be produced easily and inexpensively under industrially advantageous conditions.

  本发明提供了一种制备N-单烷基-3-羟基-3-芳基丙基胺化合物的方法，该化合物由式（2）表示：其中Ar表示可选取代的芳基或可选取代的杂环芳基，R表示可选取代的C1-5烷基，*表示不对称碳原子；该方法包括：在不对称还原催化剂的存在下，将氢气与由式（1）表示的N-苄基-N-单烷基-3-酮基-3-芳基丙烯基胺化合物反应，其中Ar和R如上所定义。本发明可以在工业上有利的条件下轻松、廉价地制备出光学活性的N-单烷基-3-羟基-3-芳基丙基胺化合物。
• WATER DISPERSION TYPE SUSTAINED RELEASE PREPARATION FOR RELEASING VOLATILE ACTIVE SUBSTANCE
  申请人：NISSIN CHEMICAL INDUSTRY CO., LTD.

  公开号：US20130230482A1

  公开（公告）日：2013-09-05

  There is provided a water dispersion for a sustained release preparation, the dispersion having viscosity at 25° C. of not more than 100 mPa·s and including polymer particles which are obtained by polymerizing ethylenically unsaturated group-containing monomers (A); at least one kind of a hydrophilic substance (B) in an amount of more than 0% by weight but not more than 20% by weight relative to a total amount of the ethylenically unsaturated group-containing monomers (A), being selected from a group consisting of a surfactant, a plasticizer and a moisturizer; polyvinyl alcohol (C) in an amount of more than 0% by weight but not more than 30% by weight relative to a total amount of the ethylenically unsaturated group-containing monomers (A), having a degree of saponification of more than 82 mol %; and water.

  提供一种水分散体，用于持续释放制剂，该分散体在25℃下的粘度不超过100mPa·s，包括通过聚合含有乙烯基不饱和基团的单体（A）而获得的聚合物颗粒；至少一种亲水性物质（B），相对于含有乙烯基不饱和基团的单体（A）的总量，重量百分比大于0％但不超过20％，所选自表面活性剂、增塑剂和保湿剂的组；聚乙烯醇（C），相对于含有乙烯基不饱和基团的单体（A）的总量，重量百分比大于0％但不超过30％，其皂化度大于82摩尔％；以及水。
• ANTIMICROBIAL COMPOUNDS, THEIR SYNTHESIS AND APPLICATIONS THEREOF
  申请人：JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESARCH

  公开号：US20150329478A1

  公开（公告）日：2015-11-19

  The present disclosure relates to the field of medicinal chemistry and more particularly to the development of antimicrobial compounds. The disclosure relates to the synthesis and characterization of compounds comprising aromatic radical or an aliphatic radical, an alkyl amine and amino acid moiety wherein said compounds exhibit antimicrobial activity against various drug-sensitive and drug-resistant pathogenic 10 microorganisms.

  本公开涉及药物化学领域，更具体地涉及抗微生物化合物的开发。本公开涉及合成和表征包含芳基或脂肪基、烷基胺和氨基酸基团的化合物，其中所述化合物对各种药物敏感和耐药的致病微生物表现出抗微生物活性。
• Glucan Compositions
  申请人：Baschong Werner

  公开号：US20090156563A1

  公开（公告）日：2009-06-18

  A cosmetic or pharmaceutical composition is provided comprising: a) 0.001 to less than 0.2% by weight, based on the weight of the total composition, of a scleroglucan having a mean molecular weight of 1×10 6 to 12×10 6 ; b) a cosmetically or pharmaceutically acceptable carrier; and, optionally, c) lactic acid, a lactate and/or pentanediol. The composition shows advantageous effects, such as moisturization of skin or mucosa, and has an antiaging and revitalizing effect on the skin. When combined with a certain bactericide as explained in claim 1 , compositions containing native polysaccharides of the glucan class in general, especially of the scleroglucan as of component a), are well suitable to reduce the number of bacteria in mucosal or oral environments and minimise adhesion, while retaining a pleasant feeling on the mucosa or gingiva. Plaque thus can be efficiently prevented or removed.

  提供一种化妆品或药物组合物，其中包括：a）占总组合物重量的0.001至少于0.2％，具有平均分子量为1×106至12×106的硬木糖聚糖；b）化妆品或药用可接受载体；以及可选的c）乳酸，乳酸盐和/或戊二醇。该组合物具有优越的效果，例如保湿皮肤或黏膜，并对皮肤具有抗衰老和活化作用。当与特定的杀菌剂结合使用时，通常含有葡聚糖类的天然多糖，特别是硬木糖聚糖作为a）组分的组合物非常适合减少黏膜或口腔环境中的细菌数量并最小化附着，同时在黏膜或牙龈上保持愉悦感。因此，可以有效地预防或去除牙菌斑。