Pentafluorphenyl-N-methylcarbamat | 14046-19-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Pentafluorphenyl-N-methylcarbamat
• 英文别名: pentafluorophenyl N-methylcarbamate；(2,3,4,5,6-pentafluorophenyl) N-methylcarbamate
• CAS: 14046-19-6
• 化学式: C₈H₄F₅NO₂
• 分子量: 241.117
• InChiKey: JJUZZGTZYVATOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Pentafluorphenyl-N-methylcarbamat 在 吡啶 、 亚硝酰氯 作用下， 反应 0.5h， 生成 pentafluorophenyl N-methyl-N-nitrosocarbamate
  参考文献：
  名称：

  Activated N-nitrosocarbamates for regioselective synthesis of N-nitrosoureas

  摘要：

  A practical and convenient method for synthesizing antitumor compounds, N-alkyl-N-nitrosoureas, regioselectively nitrosated on the nitrogen atom bearing the alkyl group is proposed. N-Alkyl-N-nitrosocarbamates are interesting intermediates in these syntheses and yield, by reaction with amino compounds, the regioselectively nitrosated N-alkyl-N-nitrosoureas. As an interesting example, N,N'-bis[(2-chloroethyl)nitrosocarbamoyl]cystamine, a new attractive oncostatic derivative, has been prepared. The cytotoxic activity of these various compounds were tested on L1210 leukemia.

  DOI：

  10.1021/jm00344a017
• 作为产物：
  描述：

  五氟苯酚 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 58.5h， 生成 Pentafluorphenyl-N-methylcarbamat
  参考文献：
  名称：

  A Convenient Method for the Synthesis of ActivatedN-Methylcarbamates

  摘要：

  报道了一种高效制备活性N-甲基氨基甲酸酯的方法。由相应氯甲酸酯5a-e制备了N-（甲基氨基甲酰氧基）琥珀酰亚胺（3a）、芳基N-甲基氨基甲酸酯3b-d和2,2,2-三氟-1-（三氟甲基）乙基N-甲基氨基甲酸酯（3e），产率为70-80%。这些氯甲酸酯是通过三氯甲基氯甲酸酯（1）或双（三氯甲基）碳酸酯（2）与羟基化合物4a-e的缩合反应，以高产率制备的结晶固体。

  DOI：

  10.1055/s-1993-25809

文献信息

• BIODEGRADABLE ORGANIC RADICAL-FUNCTIONALIZED POLYCARBONATES FOR MEDICAL APPLICATIONS
  申请人：International Business Machines Corporation

  公开号：US20160220705A1

  公开（公告）日：2016-08-04

  Paramagnetic, amphiphilic, biocompatible polymers were prepared comprising a carbonate repeat unit bearing a paramagnetic organic radical, more specifically a nitroxyl radical. The radical polymers can be produced in one step from a precursor polymer bearing an active ester side chain by treating the precursor polymer with a radical-bearing nucleophile. The precursor polymer can be prepared by organocatalyzed catalyzed ring opening polymerization (ROP) of a cyclic carbonate monomer bearing an active ester side chain. The radical polymers can be non-toxic and partially biodegradable. The radical polymers have utility as contrast enhancing agents in a medical imaging application and/or as therapeutic agents for treating a medical condition. The radical polymers can also serve as carriers for therapeutic agents (e.g., drugs) and/or medical image enhancing agents (e.g., NIRF dyes).

  具有顺磁性、两性亲疏性、生物相容性的聚合物已经制备好，其中包含一个带有顺磁性有机自由基的碳酸酯重复单元，更具体地说是一个亚硝基自由基。这种自由基聚合物可以通过将带有活性酯侧链的前体聚合物与带有自由基的亲核试剂处理而一步制备而成。前体聚合物可以通过有机催化的环氧化聚合（ROP）来制备，该环氧化单体带有活性酯侧链。这种自由基聚合物可能是无毒且部分可生物降解的。这种自由基聚合物在医学成像应用中可用作增强对比剂，和/或作为治疗医疗状况的治疗剂。这种自由基聚合物还可以作为治疗剂（例如药物）和/或医学图像增强剂（例如NIRF染料）的载体。
• [EN] CALICHEAMICIN DERIVATIVES AND ANTIBODY DRUG CONJUGATES THEREOF<br/>[FR] DÉRIVÉS DE CALICHÉAMICINE ET CONJUGUÉS ANTICORPS-MÉDICAMENTS DE CEUX-CI
  申请人：PFIZER

  公开号：WO2018138591A1

  公开（公告）日：2018-08-02

  The present invention is directed to novel calicheamicin derivatives useful as payloads in antibody-drug-conjugates (ADC's), and to payload-linker compounds and ADC compounds comprising the same; to pharmaceutical compositions comprising the same and to methods for using the same to treat pathological conditions such as cancer.

  本发明涉及新型calicheamicin衍生物，用作抗体-药物偶联物（ADC）的有效载荷，以及包含相同有效载荷-连接剂化合物和ADC化合物；涉及包含它们的药物组合物以及使用它们治疗诸如癌症等病理状态的方法。
• Cross-linked peptides containing non-peptide cross-linked structure, method for synthesizing cross-linked peptides, and novel organic compound used in method
  申请人：JITSUBO Co., Ltd.

  公开号：US10633418B2

  公开（公告）日：2020-04-28

  The purpose of the present invention is to provide a cross-linked peptide containing a novel non-peptide cross-linked structure, and a method for synthesizing the same. A cross-linked peptide having a novel non-peptide cross-linked structure, a useful intermediate for synthesizing the cross-linked peptide, and a method for synthesizing the novel cross-linked peptide and the intermediate are provided. The cross-linked peptide is characterized by having an —NR— bond in the cross-linked structure. By using the method for synthesizing the cross-linked peptide, a cross-link can be freely designed and an change can be freely made to a cross-link.

  本发明的目的是提供一种含有新型非肽交联结构的交联肽及其合成方法。本发明提供了一种具有新型非肽交联结构的交联肽、一种用于合成该交联肽的有用中间体，以及一种合成该新型交联肽和该中间体的方法。交联肽的特点是在交联结构中具有-NR-键。通过使用合成交联肽的方法，可以自由设计交联，自由改变交联。
• Konakahara Takeo, Ozaki Tomokazu, Sato Kenji, Gold Barry, Synthesis, (1993) N 1, S 103-106
  作者：Konakahara Takeo, Ozaki Tomokazu, Sato Kenji, Gold Barry

  DOI：——

  日期：——
• NOVEL CROSS-LINKED PEPTIDES CONTAINING NON-PEPTIDE CROSS-LINKED STRUCTURE, METHOD FOR SYNTHESIZING CROSS-LINKED PEPTIDES, AND NOVEL ORGANIC COMPOUND USED IN METHOD
  申请人：JITSUBO Co., Ltd.

  公开号：US20150073121A1

  公开（公告）日：2015-03-12

  The purpose of the present invention is to provide a cross-linked peptide containing a novel non-peptide cross-linked structure, and a method for synthesizing the same. A cross-linked peptide having a novel non-peptide cross-linked structure, a useful intermediate for synthesizing the cross-linked peptide, and a method for synthesizing the novel cross-linked peptide and the intermediate are provided. The cross-linked peptide is characterized by having an —NR— bond in the cross-linked structure. By using the method for synthesizing the cross-linked peptide, a cross-link can be freely designed and an change can be freely made to a cross-link.