2-hydroxy-2'-methoxydiphenylmethane | 145275-51-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-hydroxy-2'-methoxydiphenylmethane
• 英文别名: 2-(2-methoxybenzyl)phenol；2-[(2-Methoxyphenyl)methyl]phenol
• CAS: 145275-51-0
• 化学式: C₁₄H₁₄O₂
• 分子量: 214.264
• InChiKey: KPVYJCGIIZIJEK-UHFFFAOYSA-N

物化性质

• 沸点：
  339.4±22.0 °C(Predicted)
• 密度：
  1.120±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-hydroxy-2'-methoxydiphenylmethane 在 氢氧化钾 作用下， 以 甲醇 、 乙醇 、 水 为溶剂， 反应 32.0h， 生成 2-(4-methylaminobutoxy)-2'-methoxydiphenylmethane
  参考文献：
  名称：

  Synthesis and antidepressant activity of substituted (.omega.-aminoalkoxy)benzene derivatives

  摘要：

  A series of substituted (omega-aminoalkoxy)benzene derivatives has been synthesized and screened for potential antidepressant activities. The effect of structural variation of these molecules has been systematically examined. Antidepressant activity was clearly displayed by 2-benzyl-1-[4-(methylamino)butoxy]benzene (7), 2-(2-hydroxybenzyl)-1-[4-(methylamino)butoxy]benzene (19), 1-[4-(methylamino)butoxy]-2-phenoxybenzene (29), and 1-[4-(methylamino)butoxy]-2-(phenylthio)benzene (31) in further pharmacological studies. These compounds did not possess the anticholinergic, antihistaminic, and muscle-relaxant side effects common to tricyclic antidepressants.

  DOI：

  10.1021/jm00134a004
• 作为产物：
  描述：

  苯甲醚 、 2-phenyl-4H-benzo-1,3,2-dioxaborine 在 三氟化硼乙醚 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 48.0h， 生成 2-[(4-甲氧基苯基)甲基]苯酚 、 2-hydroxy-2'-methoxydiphenylmethane
  参考文献：
  名称：

  Chambers, Jeffrey D.; Crawford, Jason; Williams, Haydn W. R., Canadian Journal of Chemistry, 1992, vol. 70, # 6, p. 1717 - 1732

  摘要：

  DOI：

文献信息

• Molecular actuators, and methods of use thereof
  申请人：Anquetil A. Patrick

  公开号：US20070215839A1

  公开（公告）日：2007-09-20

  The synthesis of thiophene based conducting polymer molecular actuators, exhibiting electrically triggered molecular conformational transitions is reported. Actuation is believed to be the result of conformational rearrangement of the polymer backbone at the molecular level, not simply ion intercalation in the bulk polymer chain upon electrochemical activation. Molecular actuation results from π-π stacking of thiophene oligomers upon oxidation, producing a reversible molecular displacement that leads to surprising material properties, such as electrically controllable porosity and large strains. The existence of active molecular conformational changes is supported by in situ electrochemical data. Single molecule techniques have been used to characterize the molecular actuators.

  报道了基于噻吩的导电聚合物分子致动器的合成，展示了电触发的分子构象转变。致动被认为是分子水平上聚合物骨架的构象重排结果，而不仅仅是在电化学激活时离子在大块聚合物链中的插层。分子致动的结果来自于噻吩寡聚物的π-π堆积氧化，产生可逆的分子位移，导致惊人的材料特性，如电可控孔隙度和大应变。原位电化学数据支持活性分子构象变化的存在。单分子技术已被用于表征分子致动器。
• The Reactivity of <i>o</i>-Hydroxybenzyl Alcohol and Derivatives in Solution at Elevated Temperatures
  作者：Edwin Dorrestijn、Marieke Kranenburg、Maria Victoria Ciriano、Peter Mulder

  DOI：10.1021/jo981110f

  日期：1999.4.1

  The reactivity of o-hydroxybenzyl alcohol (o-HBA, 1), as a model compound for lignin, has been studied in various solvents between 390 and 560 K. Both in polar and apolar solvents the benzylic cation is the reactive intermediate. In alcoholic solvents, the benzylic cation reacts with the solvent to give the corresponding ethers. Relative reaction rates have been determined for different alcohols; a factor of 14 is encountered between the most (methanol) and least (tert-butyl alcohol) reactive ones. The etherification is reversible, in contrast to the electrophilic aromatic substitution with phenol and anisole, for which k(PhOH) = 1 x 10(5) M-1 s(-1) and k(anisole) = 1 x 10(4) M-1 s(-1), at 424 K. In apolar hydroaromatic solvents, 7H-benz[de]anthracene, 9,10-dihydroanthracene, and 9,10-dihydrophenanthrene, the formation of o-cresol proceeds via hydride transfer from the solvent to the benzylic cation; rate constants at 555 K are 2 x 10(6), 5 x 10(4), and 5 x 10(3) M-1 s(-1), respectively.
• KIKUMOTO RYOJI; TOBE AKIHIRO; TONOMURA SHINJI, J. MED. CHEM., 1981, 24, NO 2, 145-148
  作者：KIKUMOTO RYOJI、 TOBE AKIHIRO、 TONOMURA SHINJI

  DOI：——

  日期：——
• META CROSSLINKED BENZYL POLYMERS
  申请人：Akbar Syed

  公开号：US20130045900A1

  公开（公告）日：2013-02-21

  A meta crosslinked polar benzyl polymer is made by combining a transition metal crosslinker, or one or more source compounds capable of reacting to form such a transition metal crosslinker, with a polar benzyl polymer which has been activated for meta crosslinking
• US4562211A
  申请人：——

  公开号：US4562211A

  公开（公告）日：1985-12-31