4-(4-methoxystyryl)benzyl alcohol | 67205-76-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 4-(4-methoxystyryl)benzyl alcohol
• 英文别名: [4-[(E)-2-(4-methoxyphenyl)ethenyl]phenyl]methanol
• CAS: 67205-76-9
• 化学式: C₁₆H₁₆O₂
• 分子量: 240.302
• InChiKey: YAKQMTQHCDLRKL-NSCUHMNNSA-N

物化性质

• 熔点：
  200-202 °C(Solv: ethyl acetate (141-78-6))
• 沸点：
  417.7±14.0 °C(Predicted)
• 密度：
  1.141±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(4-methoxystyryl)benzyl alcohol 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 生成 4-[4-(4-hydroxystyryl)benzyl]heptane-3,5-dione
  参考文献：
  名称：

  Antiviral activity of some .beta.-diketones. 4. Benzyl diketones. In vitro activity against both RNA and DNA viruses

  摘要：

  The synthesis and in vitro antiviral evaluation of a series of substituted benzyl beta-diketones are described. The introduction of a styryl group onto the phenyl ring enhanced activity against herpesvirus type 2. The 4-methoxystyryl homologue 8 was evaluated extensively in vitro and was found to be effective against both RNA and DNA viruses. Compound 8 was evaluated in the mouse vagina against herpes simplex type 1 and produced a significant increase in survival rate as well as in survival time.

  DOI：

  10.1021/jm00207a010
• 作为产物：
  描述：

  (E)-4-氰基-4'-甲氧基芪 在 盐酸 、 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成 4-(4-methoxystyryl)benzyl alcohol
  参考文献：
  名称：

  Antiviral activity of some .beta.-diketones. 4. Benzyl diketones. In vitro activity against both RNA and DNA viruses

  摘要：

  The synthesis and in vitro antiviral evaluation of a series of substituted benzyl beta-diketones are described. The introduction of a styryl group onto the phenyl ring enhanced activity against herpesvirus type 2. The 4-methoxystyryl homologue 8 was evaluated extensively in vitro and was found to be effective against both RNA and DNA viruses. Compound 8 was evaluated in the mouse vagina against herpes simplex type 1 and produced a significant increase in survival rate as well as in survival time.

  DOI：

  10.1021/jm00207a010

文献信息

• Aromatic diketones
  申请人：Sterling Drug Inc.

  公开号：US04153719A1

  公开（公告）日：1979-05-08

  Beta-diketones substituted by an aryl-aliphatic group in which the aliphatic chain is interrupted by a cyclic group, and useful as anti-viral agents, are prepared by interacting the appropriate aryl-aliphatic halide with an alkali metal salt of a beta-diketone.

  通过将适当的芳基-脂肪基卤化物与β-二酮的碱金属盐相互作用，制备了由芳基-脂肪基替代的β-二酮，其中脂肪链被一个环状基团中断，并且这些化合物可用作抗病毒剂。
• DIANA G. D.; CARABATEAS P. M.; JOHNSON R. E.; WILLIAMS G. L.; PANCIC F.; +, J. MED. CHEM., 1978, 21, NO 9, 889-894
  作者：DIANA G. D.、 CARABATEAS P. M.、 JOHNSON R. E.、 WILLIAMS G. L.、 PANCIC F.、 +

  DOI：——

  日期：——
• TRANSITION METAL CATALYSTS FOR HYDRODESULFURIZATION
  申请人：GOVERNORS OF THE UNIVERSITY OF ALBERTA

  公开号：US20140174989A1

  公开（公告）日：2014-06-26

  Phosphoranimide-metal catalysts and their role in hydrodesulfurization are disclosed. The catalysts comprise of first row transition metals such as nickel, cobalt and iron. The catalysts have a metal to anionic phosphoranimide ratio of 1:1 and catalyze hydrodesulfurization of a range of sulfur-containing organic compounds under lower temperature and pressure conditions than those commonly used in industrial hydrodesulfurization.
• US4153719A
  申请人：——

  公开号：US4153719A

  公开（公告）日：1979-05-08
• US9120984B2
  申请人：——

  公开号：US9120984B2

  公开（公告）日：2015-09-01