1-(1,1,3,3-tetramethylbutyl)-2-pyrrolidinone | 52644-10-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(1,1,3,3-tetramethylbutyl)-2-pyrrolidinone
• 英文别名: 1-(2,4,4-Trimethylpentan-2-yl)pyrrolidin-2-one
• CAS: 52644-10-7
• 化学式: C₁₂H₂₃NO
• 分子量: 197.321
• InChiKey: VCZILKJCZVWPAI-UHFFFAOYSA-N

物化性质

• 沸点：
  286.6±9.0 °C(Predicted)
• 密度：
  0.945±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  γ-丁内酯 、 叔辛胺 在 1-butyl-3-methylimidazolium Tetrafluoroborate 作用下， 反应 0.58h， 以23%的产率得到1-(1,1,3,3-tetramethylbutyl)-2-pyrrolidinone
  参考文献：
  名称：

  Fast, Acid-Free, and Selective Lactamization of Lactones in Ionic Liquids

  摘要：

  A fast and acid-free one-pot 0.2-30 mmol microwave methodology for direct ionic liquid-mediated preparation of lactams from lactones and primary amines has been developed. The protocol was investigated with a wide range of primary amines and a handful of lactones, including substrates with acid-sensitive substituents. Both gamma-lactams and delta-lactams were, despite the complete absence of a Bronsted acid. obtained in useful to excellent yields after only 35 min of microwave processing.

  DOI：

  10.1021/jo8015264

文献信息

• [EN] PYRAZOLYL DERIVATIVES USEFUL AS ANTI-CANCER AGENTS<br/>[FR] DÉRIVÉS DE PYRAZOLYLE UTILES EN TANT QU'AGENTS ANTICANCÉREUX
  申请人：NOVARTIS AG

  公开号：WO2021124222A1

  公开（公告）日：2021-06-24

  The present application provides a compound of formula (I) or a stereoisomer thereof, or an atropisomer thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of a stereoisomer thereof, or a pharmaceutically acceptable salt of an atropisomer thereof; method for manufacturing said compound, and its therapeutic uses. The present application further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.

  本申请提供了化合物的公式(I)或其立体异构体，或其对映异构体，或其可接受的药物盐，或其对映异构体的可接受的药物盐，或其对映异构体的可接受的药物盐；制造该化合物的方法及其治疗用途。本申请还提供了药理活性剂的组合以及包含该化合物的药物组合物。
• RUBBER COMPOSITION FOR TIRE
  申请人：Zeon Corporation

  公开号：EP3208304A1

  公开（公告）日：2017-08-23

  Provided is a rubber composition for a tire containing a rubber component including 15 to 55 wt% of an end modified group-containing cycloolefin ring-opening polymer having a glass transition temperature of -120 to -90°C and 45 to 85 wt% of an end modified group-containing solution polymerized conjugated diene polymer having a glass transition temperature of -60 to -10°C and having an aromatic vinyl monomer unit content ratio of more than 30 wt% and 50 wt% or less, a silica, and a silane coupling agent including a monosulfide group and/or a thiol group, wherein the content of the silica with respect to 100 parts by weight of the rubber component is 30 to 200 parts by weight, and the content of the silane coupling agent including a monosulfide group and/or a thiol group with respect to 100 parts by weight of the silica is 0.3 to 20 parts by weight.

  本发明提供了一种用于轮胎的橡胶组合物，其橡胶成分包括 15 至 55 wt%的玻璃化转变温度为 -120 至 -90°C 的含端改性基团的环烯开环聚合物和 45 至 85 wt%的玻璃化转变温度为 -60 至 -10°C 的含端改性基团的溶液聚合共轭二烯聚合物，其芳香族乙烯基单体单元含量比大于 30 wt%且小于 50 wt%、白炭黑和包括单硫醚基团和/或硫醇基团的硅烷偶联剂，其中白炭黑的含量相对于 100 重量份的橡胶组分为 30 至 200 重量份，而包括单硫醚基团和/或硫醇基团的硅烷偶联剂的含量相对于 100 重量份的白炭黑为 0.3 至 20 份（重量比）。
• RUBBER COMPOSITION FOR TIRES
  申请人：Zeon Corporation

  公开号：EP3208303A1

  公开（公告）日：2017-08-23

  Provided is a rubber composition for a tire containing a cyclopentene ring-opening polymer and a solution polymerized styrene-butadiene rubber. The present invention can provide a rubber composition for a tire containing a cyclopentene ring-opening polymer, which can give a cross-linked rubber excellent in wet grip and low heat buildup property.

  本发明提供了一种用于轮胎的橡胶组合物，其中含有环戊烯开环聚合物和溶液聚合丁苯橡胶。本发明可提供一种含有环戊烯开环聚合物的轮胎橡胶组合物，该组合物可提供一种湿抓地力和低热积性能优异的交联橡胶。
• [EN] IMPROVED CONTAMINANT REMOVAL PROCESS<br/>[FR] PROCESSUS AMÉLIORÉ D'ÉLIMINATION DE CONTAMINANTS
  申请人：TAMINCO BVBA

  公开号：WO2019158591A1

  公开（公告）日：2019-08-22

  Disclosed is a process comprising: step a) contacting a feed stream comprising a contaminant with an absorbent stream in a counter-current flow to produce a contaminant depleted product stream depleted in the molar quantity of the contaminant relative to the molar quantity of said contaminant in the feed stream, and a contaminant enriched absorbent stream enriched in the molar quantity of the contaminant relative to the molar quantity of said contaminant in the absorbent stream; and step b) treating the contaminant enriched absorbent stream to form a gaseous stream comprising said contaminant and a regenerated absorbent stream lean in the molar quantity of said contaminant relative to the molar quantity of said contaminant in the contaminant enriched absorbent stream; herein said absorbent stream comprises at least 15 wt.% of at least one compound (A) of general formula (I) or a mixture (M) comprising at least one compound (B) of general formula (II) and at least one compound (C) of general formula (III).
• [EN] PYRAZOLYL DERIVATIVES USEFUL AS ANTI-CANCER AGENTS<br/>[FR] DÉRIVÉS PYRAZOLYLE UTILES EN TANT QU'AGENTS ANTICANCÉREUX
  申请人：NOVARTIS AG

  公开号：WO2021120890A1

  公开（公告）日：2021-06-24

  Provided is a compound of formula (I) or a stereoisomer thereof, or an atropisomer thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of a stereoisomer thereof, or a pharmaceutically acceptable salt of an atropisomer thereof; a method for manufacturing said compound, and its therapeutic uses. Provided are a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.