bromure d'heptyltriphenylphosphonium | 59724-99-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bromure d'heptyltriphenylphosphonium
• 英文别名: heptyltriphenylphosphonium bromide；triphenylheptylphosphonium bromide；n-heptyltriphenylphosphine bromide；Bromo-heptyl-triphenyl-lambda5-phosphane；bromo-heptyl-triphenyl-λ5-phosphane
• CAS: 59724-99-1
• 化学式: C₂₅H₃₀BrP
• 分子量: 441.391
• InChiKey: GTNQYWUKKZGRNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  (2E)-4,5,6-tri-O-acetyl-2,3-dideoxy-D-threo-hex-2-enose 、 bromure d'heptyltriphenylphosphonium 在 1.) C₄H₉Li 作用下， 生成 1,2R,3R-triacetoxy-4E,6Z-tridecadiene
  参考文献：
  名称：

  Tolstikov, A. G.; Khakhalina, N. V.; Odinokov, V. N., Journal of Organic Chemistry USSR (English Translation), 1987, vol. 23, p. 2182 - 2183

  摘要：

  DOI：
• 作为产物：
  描述：

  1-溴代庚烷 、 三苯基膦 生成 bromure d'heptyltriphenylphosphonium
  参考文献：
  名称：

  XUSID A. X.; KOVALEV B. G., ZH. ORGAN. XIMII, 23,(1987) N 11, 71-78

  摘要：

  DOI：

文献信息

• SUBSTITUTED CYCLOPENTANES HAVING PROSTAGLANDIN ACTIVITY
  申请人：Donde Yariv

  公开号：US20090124676A1

  公开（公告）日：2009-05-14

  Disclosed herein are compounds having a formula: Therapeutic methods, medicaments, and compositions related thereto are also disclosed.

  本文揭示了具有以下化学式的化合物：还公开了与之相关的治疗方法、药物和组合物。
• Biaromatic amido compounds and pharmaceutical/cosmetic compositions
  申请人：Centre International de Recherches Dermatologiques Galderma

  公开号：US05935585A1

  公开（公告）日：1999-08-10

  Novel pharmaceutically/cosmetically-active biaromatic amido compounds have the structural formula (I): ##STR1## in which Ar is a radical selected from among those of the following formulae (a)-(e): ##STR2## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.

  新型药用/化妆品活性双芳基酰胺化合物具有结构式(I)：##STR1## 其中Ar是从以下式(a)-(e)中选择的基团：##STR2## 并且适用于治疗各种疾病状态，无论是人类还是兽医，例如皮肤病、风湿病、呼吸系统疾病、心血管疾病和眼科疾病，以及哺乳动物皮肤和毛发状况/疾病的治疗。
• Novel asymmetric syntheses of (−)-malyngolide and (+)-epi-malyngolide
  作者：Dieter Enders、Monika Knopp

  DOI：10.1016/0040-4020(96)00236-0

  日期：1996.4

  diastereo- and enantioselective synthesis of (−)-malyngolide [(S, R)-1], an antibiotic against Mycobacterium smegmatis and Streptococcus pyogenes, using the asymmetric Carroll rearrangement as key step is described. Furthermore, the diastereo- and enantioselective synthesis by double α, α′-alkylation using SAMP/RAMP hydrazone methodology affords the diastereomer (+)- epi-malyngolide [(S, S)-1].

  描述了使用不对称卡洛尔重排作为关键步骤的抗耻垢分枝杆菌和化脓性链球菌抗生素（-）-麦芽糖内酯[（S，R）-1 ]的非对映和对映选择性合成。此外，使用SAMP / RAMP methodology方法通过双重α，α'-烷基化进行非对映和对映选择性合成，得到非对映异构体（+）-表位-麦芽甘露酯[（S，S）-1 ]。
• Synthèse de composés cyclopentaniques chiraux, di, tri et tétrasubstitués. Application à la synthèse de dérivés Oxa-13-prostanoïques
  作者：Jean-Claude Barrière、Jeanine Cléophax、Stephan D. Géro、Marc Vuilhorgne

  DOI：10.1002/hlca.19830660508

  日期：1983.7.27

  The cyclopentenecarbaldehyde 1a, acetals 2a, 2b and the cyclopentenone 2c have been transformed through regio and stereocontrolled reactions into a variety of enantiomerically pure substituted cyclopentanes. Using appropriately selected Wittig reagents, aldehyde 1a furnished the condensation products 3, 4, 5. Michael addition of diethyl malonate on the α,β-unsaturated aldehyde 1a under phasetransfer

  环戊烯甲醛1a，乙缩醛2a，2b和环戊烯酮2c已通过区域和立体控制反应转化为多种对映体纯的取代的环戊烷。使用适当选择的维悌希试剂，醛1A提供的缩合产物3，4，5。在相转移条件下，丙二酸二乙酯在α，β-不饱和醛1a上的迈克尔加成反应有效地导致了7。还原环戊烯酮2c得到21高产。的环戊烯图2a，图2b和23，提交给硼氢化-氧化提供的cyclopentanols 10，13和24，分别在30,70和50％的产率，这反映了起始烯烃的取代模式。这些反应的显着特征是由于分子1a，2a，2b和2c的手性中心而导致的立体特异性，导致具有两个，三个和四个不对称中心的化合物。11α-羟基-13-氧杂前列腺素酸20的直接合成本文描述了一种制备9α，11α-二羟基-13-氧杂前列腺素酸34的方法。这些产物的结构已通过1 H-和13 C-NMR光谱测定。
• Asymmetric synthesis of 5- and 6-membered lactones from cyclic substrates bearing a C2-chiral auxiliary
  作者：Yukio Yamamoto、Akio Sakamoto、Takaaki Nishioka、Junichi Oda、Yoshimasa Fukazawa

  DOI：10.1021/jo00003a038

  日期：1991.2

  Optically active lactones were synthesized by a novel asymmetric synthesis in which enantiotopic groups remote from a prochiral center were effectively discriminated. The cyclic diamide alcohols bearing a C2-chiral auxiliary, (+)-[1,1'-binaphthyl]-2,2'-diamine (4), were designed and prepared such that the hydroxyl group should attack preferentially at one of the two carbonyl groups. By the catalytic action of trifluoroacetic acid, the substrates 6a,b and 19 were smoothly converted to the lactones 7a (71% de), 7b (97% de), and 20 (> 99% de), the configurations of which were determined to be R, S, and R, respectively. A naturally occurring pheromone, (R)-(+)-5-hexadecanolide (13), was synthesized optically pure from 7b. Transition-state models for the present asymmetric lactonization were constructed according to the stereoelectronic theory proposed by Deslongchamps. The stability of the models was assessed by MM2 calculation, and the direction of asymmetric induction thus calculated coincided with the experimental results.