NSC377384 | 197311-21-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: NSC377384
• 英文别名: N-(3-cyanophenyl)-N'-(4-cyanophenyl)urea；1-(3-Cyanophenyl)-3-(4-cyanophenyl)urea
• CAS: 197311-21-0
• 化学式: C₁₅H₁₀N₄O
• 分子量: 262.271
• InChiKey: NYZGNHFUJIBFKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  88.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  NSC377384 在 盐酸 、 碳酸氢铵 、 sodium hydride 作用下， 反应 57.0h， 生成 3-(3-{4-[(Z)-amino(imino)methyl]phenyl}-2-oxo-1,3-diazepan-1-yl)benzenecarboximidamide
  参考文献：
  名称：

  The de novo design and synthesis of cyclic urea inhibitors of factor Xa: Initial sar studies

  摘要：

  In this report we discuss the design, synthesis, rind validation of a novel series of cyclic urea inhibitors of the blood coagulation protein Factor Xa. This work culminates in compound 11, a mono-amidine inhibitor of fXa employing a new S4 ligand that reduces the cationic character of these analogs. Compound 11 represents a lead for a series of more potent and selective inhibitors. (C) 1998 The DuPont Merck Pharmaceutical Company. Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00471-5
• 作为产物：
  描述：

  异氰酸间氰基苯酯 、 对氨基苯腈 以 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 生成 NSC377384
  参考文献：
  名称：

  The de novo design and synthesis of cyclic urea inhibitors of factor Xa: Initial sar studies

  摘要：

  In this report we discuss the design, synthesis, rind validation of a novel series of cyclic urea inhibitors of the blood coagulation protein Factor Xa. This work culminates in compound 11, a mono-amidine inhibitor of fXa employing a new S4 ligand that reduces the cationic character of these analogs. Compound 11 represents a lead for a series of more potent and selective inhibitors. (C) 1998 The DuPont Merck Pharmaceutical Company. Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00471-5

文献信息

• N-(amidinophenyl) cyclourea analogs as factor XA inhibitors
  申请人：DuPont Pharmaceuticals Company

  公开号：US05925635A1

  公开（公告）日：1999-07-20

  The present application describes N-(amidinophenyl)cyclourea analogs of formula I: ##STR1## which are useful as inhibitors of factor Xa.

  本申请描述了公式I的N-(酰胺基苯基)环脲类似物：##STR1##，其作为因子Xa的抑制剂是有用的。
• [EN] N-(AMIDINOPHENYL)-N'-(SUBST.)-3H-2,4-BENZODIAZEPIN-3-ONE DERIVATIVES AS FACTOR XA INHIBITORS<br/>[FR] DERIVES DE N-(AMIDINOPHENYL)-N'-(SUBST.)-3H-2,4-BENZODIAZEPINE-3-ONE EN TANT QU'INHIBITEURS DU FACTEUR Xa
  申请人：DU PONT PHARMACEUTICALS COMPANY

  公开号：WO1997038984A1

  公开（公告）日：1997-10-23

  (EN) The present application describes N-(amidinophenyl) cyclourea analogs of formula (I) which are useful as inhibitors of factor Xa.(FR) Analogues N- (amidinophenyl) de cyclo-urée définis par la formule (I) qui sont des inhibiteurs efficaces du facteur Xa.

  该申请描述了公式（I）的N-（amidinophenyl）cyclourea类似物，这些类似物可用作因子Xa的抑制剂。这些类似物被定义为N-（amidinophenyl）的环状尿素衍生物，可作为因子Xa的有效抑制剂。
• N-(amidinophenyl)cyclourea analogs as factor Xa inhibitors
  申请人：Bristol-Myers Squibb Pharma Company

  公开号：US06521614B1

  公开（公告）日：2003-02-18

  The present application describes N-(amidinophenyl)cyclourea analogs of formula I: which are useful as inhibitors of factor Xa.

  本申请描述了公式I的N-(酰胺基苯基)环脲类似物，其可用作因子Xa的抑制剂。
• N-(AMIDINOPHENYL)-N'-(SUBST.)-3H-2,4-BENZODIAZEPIN-3-ONE DERIVATIVES AS FACTOR XA INHIBITORS
  申请人：Du Pont Pharmaceuticals Company

  公开号：EP0960104A1

  公开（公告）日：1999-12-01
• SMALL MOLECULES FOR RESTORING FUNCTION TO P53 CANCER MUTANTS
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20150307519A1

  公开（公告）日：2015-10-29

  Embodiments of the present provide methods of inducing p53 SRMMP-dependent cancer cell cytotoxicity. Such methods involve the steps of exposing a cancer cell that comprises a p53 SRMMP to an amount of a chemical compound sufficient to induce p53 SRMMP-dependent cancer cell cytotoxicity. In one embodiment, the present invention provides a method of treating cancer by determining the presence of a p53 mutation, and administering a therapeutically effective dosage of a composition comprising one or more promoting compounds.