NSC16224 | 132-34-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: NSC16224
• 英文别名: 3-amino-4-[4'-(2-amino-6-sulfo-[1]naphthylazo)-3,3'-dimethyl-biphenyl-4-ylazo]-naphthalene-2,7-disulfonic acid；3-Amino-4-[4'-(2-amino-6-sulfo-[1]naphthylazo)-3,3'-dimethyl-biphenyl-4-ylazo]-naphthalin-2,7-disulfonsaeure；4'-(2-Amino-6-sulfo-naphthyl-(1)-azo)-4-(2-amino-3.6-disulfo-naphthyl-(1)-azo)-3.3'-dimethyl-biphenyl；(Naphthylamin-(2)-sulfonsaeure-(6))-(1 azo 4)-(3.3'-dimethyl-diphenyl)-(4'azo 1)-(naphthylamin-(2)-disulfonsaeure-(3.6))
• CAS: 132-34-3
• 化学式: C₃₄H₂₈N₆O₉S₃
• 分子量: 760.829
• InChiKey: OFGVQLJUXSRVEG-HVMBLDELSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.01
• 重原子数：
  52.0
• 可旋转键数：
  8.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  264.59
• 氢给体数：
  5.0
• 氢受体数：
  12.0

反应信息

• 作为产物：
  描述：

  4,4'-二氨基-3,3'-二甲基联苯 生成 NSC16224
  参考文献：
  名称：

  Schultz, Tab.7.Aufl.,No.452

  摘要：

  DOI：

文献信息

• Methods of identifying SENP1 inhibitors
  申请人：City of Hope

  公开号：US11041859B2

  公开（公告）日：2021-06-22

  Provided herein are methods of detecting binding of an SENP1 polypeptide to a compound and methods for screening for inhibitors of SENP1. Further provided are aqueous compositions comprising SENP1 polypeptides and NMR apparatuses comprising the compositions for NMR analysis.

  本文提供了检测 SENP1 多肽与化合物结合的方法以及筛选 SENP1 抑制剂的方法。还提供了包含 SENP1 多肽的水性组合物和包含该组合物的 NMR 仪器，用于 NMR 分析。
• Palkin; Evans, Journal of the American Chemical Society, 1925, vol. 47, p. 433
  作者：Palkin、Evans

  DOI：——

  日期：——
• Schultz, Tab.7.Aufl.,No.452
  作者：Schultz

  DOI：——

  日期：——
• Small-molecule inhibitors of angiogenin and rnases and in vivo and in vitro methods of using same
  申请人：Shapiro Robert

  公开号：US20070032418A1

  公开（公告）日：2007-02-08

  Lead compounds were obtained in a high throughput screen (HTS) of angiogenin (ANG; a potent inducer of angiogenesis) enzyme activity, an RNase. One lead was shown to delay appearance of tumors in an animal tumor system, and to reduce the number of animals having tumors. Several lead compound analogs were found to be even more potent inhibitors of ANG activity compared to the original leads, and two were also found to have greater affinity for ANG than for pancreatic RNase. Other embodiments disclose a method comprising obtaining a ribonuclease inhibitor and a composition; and admixing the ribonuclease inhibitor and the composition to form an admixture, wherein a ribonuclease that may be present in the admixture is inhibited.
• METHODS OF IDENTIFYING SENP1 INHIBITORS
  申请人：City of Hope

  公开号：US20140302525A1

  公开（公告）日：2014-10-09

  Provided herein are methods of detecting binding of an SENP1 polypeptide to a compound and methods for screening for inhibitors of SENP1. Further provided are aqueous compositions comprising SENP1 polypeptides and NMR apparatuses comprising the compositions for NMR analysis.