3,5-二乙基苯甲醛 | 81698-95-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3,5-二乙基苯甲醛
• 英文名称: 3,5-diethylbenzaldehyde
• 英文别名: 3,5-Diaethyl-benzaldehyd；3,5-Diethyl-benzaldehyd；3,5-Diethylbenzaldehyd
• CAS: 81698-95-5
• 化学式: C₁₁H₁₄O
• mdl: MFCD09743751
• 分子量: 162.232
• InChiKey: PNJMDOYTIFLVEX-UHFFFAOYSA-N

物化性质

• 沸点：
  128 °C(Press: 20 Torr)
• 密度：
  0.972±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2912299000

反应信息

• 作为反应物：
  描述：

  3,5-二乙基苯甲醛 在 potassium permanganate 作用下， 生成 3,5-二乙基苯甲酸
  参考文献：
  名称：

  Wiemann,J.; Lacroix,P., Bulletin de la Societe Chimique de France, 1961, p. 2257 - 2269

  摘要：

  DOI：
• 作为产物：
  描述：

  2-乙基-2-己烯醛 、 丁烯-2-醛 在 magnesium 作用下， 生成 3,5-二乙基苯甲醛
  参考文献：
  名称：

  Godfroid,J.J. et al., Bulletin de la Societe Chimique de France, 1966, p. 3238 - 3243

  摘要：

  DOI：

文献信息

• Isoquinolines as IGF-1R Inhibitors
  申请人：Gunzinger Jan

  公开号：US20090099229A1

  公开（公告）日：2009-04-16

  Compounds of the formula (I): were synthesized. In at least one embodiment, they were found to down-regulate or inhibit the expression or function of the IGF-1 receptor.

  公式（I）的化合物被合成。在至少一个实施例中，发现它们能够下调或抑制IGF-1受体的表达或功能。
• COMPOUNDS AND MATRICES FOR USE IN BONE GROWTH AND REPAIR
  申请人：HUMAN BIOMOLECULAR RESEARCH INSTITUTE

  公开号：US20160038641A1

  公开（公告）日：2016-02-11

  Compositions of small molecules, matrices, and isolated cells including methods of preparation, and methods for differentiation, transdifferentiation, and proliferation of animal cells into the osteoblast blast cell lineage were described. Examples of osteogenic materials that were administered to cells or co-cultured with cells are represented by compounds of Formula II, IV, and VI independently or preferably in combination with a matrix to afford bone cells. Small molecule-stimulated cells were also combined with a matrix, placed with a cellular adhesive or material carrier and implanted to a site in an animal for bone repair. Matrix pretreated with compounds of Formula II, IV, and VI were also used to cause cells to migrate to the matrix that is of use for therapeutic purposes.

  描述了由小分子、基质和孤立细胞组成的组合物，包括制备方法，以及动物细胞分化、转分化和增殖成骨母细胞谱系的方法。给细胞施加的或与细胞共培养的成骨材料的示例由独立或首选与基质组合的Formula II、IV和VI化合物代表。受小分子刺激的细胞还与基质结合，与细胞粘合剂或材料载体一起植入到动物体内的部位进行骨修复。预先用Formula II、IV和VI化合物处理的基质也被用于导致细胞迁移到用于治疗目的的基质上。
• Asymmetric Counteranion-Directed Catalytic Hosomi-Sakurai Reaction
  作者：Manuel Mahlau、Pilar García-García、Benjamin List

  DOI：10.1002/chem.201203623

  日期：2012.12.14

  Lewis acid catalyzed Hosomi–Sakurai reaction of (hetero)aromatic aldehydes and allylsilanes using an easily handled disulfonimide precatalyst (see scheme). The key to the success of this system is to turn the usually undesired silylium ion catalysis into the desired catalytic regime and pair the cation with an enantiopure disulfonimide anion, thereby applying the concept of asymmetric counteranion‐directed

  抗衡阴离子的控制可使用易于处理的二磺酰亚胺预催化剂使对映体选择性有机路易斯酸催化（杂）芳族醛和烯丙基硅烷的Hosomi-Sakurai反应（参见方案）。该系统成功的关键在于将通常不希望的甲硅烷基离子催化转化为所需的催化方案，并将阳离子与对映体纯的二磺酰亚胺阴离子配对，从而应用了不对称抗衡阴离子导向催化的概念。
• The Catalytic Asymmetric Abramov Reaction
  作者：Joyram Guin、Qinggang Wang、Manuel van Gemmeren、Benjamin List

  DOI：10.1002/anie.201409411

  日期：2015.1.2

  The first catalytic enantioselective Abramov reaction is described. The process is based on the utilization of a chiral disulfonimide catalyst, which efficiently avoids the difficulties encountered with metal‐based catalysts. Several functionalized α‐hydroxy phosphonates were synthesized in good yields and with excellent enantiomeric ratios of up to >99:1. The process was shown to be scalable and up

  描述了第一催化对映选择性阿布拉莫夫反应。该工艺基于手性二磺酰亚胺催化剂的利用，可有效避免金属基催化剂遇到的困难。合成了几种功能化的α-羟基膦酸酯，收率高，对映体比例高达> 99：1。该方法显示出可扩展性，并且在温和的反应条件下可以使用多达1 g的原料。
• Catalytic Asymmetric Three-Component Synthesis of Homoallylic Amines
  作者：Shikha Gandhi、Benjamin List

  DOI：10.1002/anie.201209776

  日期：2013.2.25

  It takes three to make things go right: The first direct asymmetric three‐component reaction of aldehydes, carbamates, and allyltrimethylsilane leading to enantioenriched homoallylic amines has been developed using a new chiral disulfonimide catalyst (see scheme). The method employs readily available, inexpensive, and nontoxic starting materials and is applicable to both aromatic and aliphatic aldehydes

  要使事情顺利进行，需要三个步骤：使用新的手性二磺酰亚胺催化剂开发了醛，氨基甲酸酯和烯丙基三甲基硅烷的第一个直接不对称三组分反应，导致对映体富集的烯丙基胺。该方法使用容易获得，廉价且无毒的起始原料，并且适用于芳族和脂族醛。