4-pyridine-3-yl-benzoic acid hydrochloride | 175153-10-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-pyridine-3-yl-benzoic acid hydrochloride
• 英文别名: 4-pyridin-3-ylbenzoic acid hydrochloride；4-(pyridin-3-yl)benzoic acid HCl；4-(3-pyridyl)benzoic acid hydrochloride；4-pyridin-3-ylbenzoic acid;hydrochloride
• CAS: 175153-10-3
• 化学式: C₁₂H₉NO₂*ClH
• 分子量: 235.67
• InChiKey: BJTUFABCKIEIGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.87
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(4-(2,3-二氯苯基)哌嗪-1-基)-反-丁-2-烯基胺 、 4-pyridine-3-yl-benzoic acid hydrochloride 在 吡啶 、 N,N'-羰基二咪唑 作用下， 以 氯仿 为溶剂， 反应 1.0h， 以31%的产率得到N-{4-[4-(2,3-Dichloro-phenyl)-piperazin-1-yl]-but-2-enyl}-4-pyridin-3-yl-benzamide
  参考文献：
  名称：

  Novel Heterocyclic Trans Olefin Analogues of N-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as Selective Probes with High Affinity for the Dopamine D3 Receptor

  摘要：

  Dopamine D3 receptor subtypes have been hypothesized to play a pivotal role in modulating the reinforcing and drug-seeking effects induced by cocaine. However, definitive pharmacological investigations have been hampered by the lack of highly D3 receptor selective compounds that can be used in vivo. To address this problem, the potent and D3-receptor-selective antagonist NGB 2904 (1, 9H-fluorene-2-carboxylic acid {4-[(2,3-dichlorophenyl)-piperazin-1-yl]-butyl} amide, K-i (hD3) = 2.0 nM, K-i (hD2(L)) = 112 nM, D2/D3 selectivity ratio of 56) was chosen as a lead structure for chemical modification in an attempt to reduce its high lipophilicity (c log D = 6.94) while optimizing D3 receptor binding affinity and D2/D3 selectivity. A series of >30 novel analogues were synthesized, and their binding affinities were evaluated in competition binding assays in HEK 293 cells transfected with either D2(L), D3, or D4 human dopamine receptors using the high affinity, selective D2-like receptor antagonist I-125-IABN. Structural diversity in the aryl amide end of the molecule Was found to have a major influence on (sub)nanomolar D3 receptor affinity and D2/D3 selectivity, which was optimized using a more rigid trans-butenyl linker between the aryl amide and the piperazine. Several analogues demonstrated superior D3 receptor binding affinities and selectivities as compared to the parent ligand. Compound 29 (N-{4-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-pyridine- 2-yl-benzamide) displayed the most promising pharmacological profile (K-i (hD3) = 0.7 nM, K-i (hD2(L)) = 93.3 nM, D2/D3 selectivity ratio of 133). In addition, this ligand inhibited quinpirole stimulation of mitogenesis at human dopamine D3 receptors transfected into Chinese hamster ovary (CHO) cells, with an EC50 value of 3.0 nM. Compound 29 was a nearly 5 times more potent antagonist at the D3 receptor than 1 (EC50 = 14.4 nM). Moreover, a decrease in c log D value of similar to2 orders of magnitude was determined for this novel D3-receptor-preferring ligand, compared to 1. In summary, chemical modification of 1 has resulted in compounds with high affinity and selectivity for D3 receptors. The most promising candidate, compound 29, is currently being evaluated in animal models of cocaine abuse and will provide an important tool with which to elucidate the role of D3 receptors in drug reinforcement in vivo.

  DOI：

  10.1021/jm049465g
• 作为产物：
  描述：

  4-(3-吡啶)苯甲酸甲酯 以 四氢呋喃 、 1,4-二氧六环 、 盐酸 为溶剂， 以93%的产率得到4-pyridine-3-yl-benzoic acid hydrochloride
  参考文献：
  名称：

  NOVEL SULFONYL DERIVATIVES

  摘要：

  以下是通用公式（I）所代表的磺酰衍生物：Q1-Q2-T1-Q3-SO2-QA以及含有这些衍生物的药物（其中Q1是可选择地取代的饱和或不饱和的五元或六元环烃基团，五元或六元杂环基团等；Q2是单键，氧，硫，C1-C6烷基或类似物；QA是可选择地取代的芳基烯烃基团，杂环芳基烯烃基团或类似物；T1是羰基或类似物）。这些化合物具有强大的FXa抑制作用，并通过口服迅速产生令人满意且持久的抗血栓作用，因此可作为几乎不伴随副作用的抗凝血剂。

  公开号：

  EP1104754A1

文献信息

• LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism
  作者：Marie-Céline Frantz、Lucie P. Pellissier、Elsa Pflimlin、Stéphanie Loison、Jorge Gandía、Claire Marsol、Thierry Durroux、Bernard Mouillac、Jérôme A. J. Becker、Julie Le Merrer、Christel Valencia、Pascal Villa、Dominique Bonnet、Marcel Hibert

  DOI：10.1021/acs.jmedchem.8b00697

  日期：2018.10.11

  affinity and efficacy of representative ligands of the V1a and V2 vasopressin receptor subtypes (V1a-R and V2-R) and of the oxytocin receptor. Our results confirm the subtlety of the structure–affinity and structure–efficacy relationships around vasopressin/oxytocin receptor ligands and lead however to the first nonpeptide OT receptor agonist active in a mouse model of ASD after peripheral ip administration

  催产素（OT）及其受体（OT-R）与自闭症谱系障碍（ASD）的病因有关，并且OT-R是治疗干预的潜在目标。当前已经报道了极少的非肽催产素激动剂。它们的分子和体内药理学仍有待阐明，并且没有显示它们在改善与ASD相关的动物模型中的社会互动方面有效。为了合理设计中枢活性非肽全激动剂的设计，我们以系统的方式研究了V 1a和V 2加压素受体亚型（V 1a -R和V 2）的代表性配体的亲和力和功效的结构决定因素。-R）和催产素受体。我们的研究结果证实了血管加压素/催产素受体配体周围的结构亲和力和结构功效关系的微妙之处，但是导致了在外围腹膜内注射后在ASD小鼠模型中首个活性的非肽OT受体激动剂。
• Sulfonyl derivatives
  申请人：Daiichi Pharmaceutical Co., Ltd.

  公开号：US06525042B1

  公开（公告）日：2003-02-25

  Sulfonyl derivatives represented by general formula (I), salts of the same, and solvates of both: and application of them as drugs: [wherein R1 is hydrogen, hydroxyl, nitro or the like; R2 and R3 are each independently hydrogen, halogeno or the like; R4 and R5 are each dependently hydrogen, halogeno or the like; Q1 is an optionally substituted saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group or the like; Q2 is a single bond, oxygen or the like; Q3 is, e.g., a group represented by formula (a): T1 is carbonyl or the like; and X1 and X2 are each independently methylidyne or nitrogen]. These compounds exhibit potent Fxa inhibiting activities and serve as excellent anticoagulants which speedily exert satisfactory and persistent anti-thrombotic effects through oral administration and little cause adverse effects.

  通用公式(I)表示的磺酰衍生物，其盐以及两者的溶剂化合物：以及它们作为药物的应用：[其中R1是氢、羟基、硝基或类似物；R2和R3各自独立地是氢、卤素或类似物；R4和R5各自依赖于氢、卤素或类似物；Q1是可选择取代的饱和或不饱和的5-或6-成员环烃基或类似物；Q2是单键、氧或类似物；Q3是，例如，由公式(a)表示的基团：T1是羰基或类似物；X1和X2各自独立地是甲基亚砜或氮。这些化合物表现出强大的Fxa抑制活性，并作为优秀的抗凝血剂，通过口服迅速产生令人满意且持久的抗血栓效果，并几乎不引起不良反应。
• Novel sulfonyl derivatives
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：US20040082611A1

  公开（公告）日：2004-04-29

  Described in the present invention are a sulfonyl derivative represented by the following formula (I): Q 1 -Q 2 -T 1 -Q 3 -SO 2 -Q A (I) [wherein Q 1 represents a saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group, 5- or 6-membered heterocyclic group, dicyclic fused ring or tricyclic fused ring group which may have a substituent; Q 2 represents a single bond, an oxygen atom, a sulfur atom, a linear or branched C 1-6 alkylene group or the like; Q A represents an arylalkenyl group which may have a substituent or a heteroarylalkenyl group which may have a substituent; and T 1 represents a carbonyl group or the like] and a medicament comprising the same. The compound has strong FXa inhibitory action, provides prompt, sufficient and long-lasting anti-thrombus effects when orally administered, and has low side effects and is therefore useful as an excellent anticoagulant.

  本发明描述了一种由以下式(I)表示的磺酰基衍生物： Q1-Q2-T1-Q3-SO2-QA(I) [其中，Q1表示饱和或不饱和的5-或6-环烃基、5-或6-杂环基、二环融合环或三环融合环基，可能具有取代基；Q2表示单键、氧原子、硫原子、线性或支链的C1-6烷基等；QA表示可能具有取代基的芳基烯基或杂芳基烯基；T1表示羰基基团或类似物]，以及包含该化合物的药物。该化合物具有强烈的FXa抑制作用，口服后提供快速、充分和持久的抗血栓效果，并且具有低副作用，因此可用作优秀的抗凝剂。
• Novel ethylenediamine derivatives
  申请人：Nakamoto Yumi

  公开号：US20070129371A1

  公开（公告）日：2007-06-07

  A compound represented by the following formula (1): Q 1 —Q 2 —T o —N(R 1 )—Q 3 —N(R 2 )—T 1 —Q 4 ( 1 ) [wherein, R 1 and R 2 are hydrogen atoms or the like; Q 1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may have a substituent, or the like; Q 2 is a single bond or the like; Q 3 represents the following group: —C(R 3a )(R 4a )—C(R 3b )(R 4b )}m 1 —C(R 3c )(R 4c )}m 2 —C(R 3d )(R 4d )}m 3 —C(R 3e )(R 4e )}m 4 —C (R 3f )(R 4f )— (in which, R 3a to R 4e represent hydrogen or the like); T 0 represents a carbonyl group or the like; and T 1 represents —COCONR— or the like]; or salt thereof, solvate thereof, or N-oxide thereof. The compound is useful as a preventive and/or therapeutic agent for cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

  以下化合物公式（1）表示的化合物：Q1-Q2-To-N（R1）-Q3-N（R2）-T1-Q4（1）[其中，R1和R2是氢原子或类似物；Q1是饱和或不饱和的5或6元环烃基，可以具有取代基或类似物；Q2是单键或类似物；Q3表示以下基团：-C（R3a）（R4a）-C（R3b）（R4b）}m1-C（R3c）（R4c）}m2-C（R3d）（R4d）}m3-C（R3e）（R4e）}m4-C（R3f）（R4f）-（其中，R3a到R4e代表氢或类似物）；T0表示羰基基团或类似物；T1表示-COCONR-或类似物]；或其盐，溶剂化合物或N-氧化物。该化合物可用作预防和/或治疗脑梗死、脑栓塞、心肌梗死、心绞痛、肺梗死、肺栓塞、布尔格病、深静脉血栓形成、弥漫性血管内凝血综合征、瓣膜或关节置换后的血栓形成、血管成形术后的血栓形成和再闭塞、全身性炎症反应综合征（SIRS）、多器官功能障碍综合征（MODS）、体外循环期间的血栓形成或采血时的血液凝固。
• Dopamine D₃/D₂ Receptor Ligands Based on Cariprazine for the Treatment of Psychostimulant Use Disorders That May Be Dual Diagnosed with Affective Disorders
  作者：Emma S. Gogarnoiu、Caleb D. Vogt、Julie Sanchez、Alessandro Bonifazi、Elizabeth Saab、Anver Basha Shaik、Omar Soler-Cedeño、Guo-Hua Bi、Benjamin Klein、Zheng-Xiong Xi、J. Robert Lane、Amy Hauck Newman

  DOI：10.1021/acs.jmedchem.2c01624

  日期：2023.2.9

  Highly selective dopamine D3 receptor (D3R) partial agonists/antagonists have been developed for the treatment of psychostimulant use disorders (PSUD). However, none have reached the clinic due to insufficient potency/efficacy or potential cardiotoxicity. Cariprazine, an FDA-approved drug for the treatment of schizophrenia and bipolar disorder, is a high-affinity D3R partial agonist (Ki = 0.22 nM) with

  高选择性多巴胺 D 3受体 (D 3 R) 部分激动剂/拮抗剂已被开发用于治疗精神兴奋剂使用障碍 (PSUD)。然而，由于效力/功效不足或潜在的心脏毒性，尚未进入临床。 Cariprazine 是 FDA 批准的用于治疗精神分裂症和双相情感障碍的药物，是一种高亲和力 D 3 R 部分激动剂 ( K i = 0.22 nM)，其选择性是同源多巴胺 D 2受体 (D 2 R) 的 3.6 倍。我们假设中等 D 3 R/D 2 R 选择性部分激动剂/拮抗剂的化合物可能对 PSUD 的治疗有效。通过系统地修饰母体分子，我们发现了部分激动剂/拮抗剂（在基于生物发光共振能量转移 (BRET) 的测定中测量）具有高 D 3 R 亲和力 ( K i = 0.14–50 nM) 和中等选择性 (<100-折叠 id=63>2 R. 卡利拉嗪和两种先导类似物13a和13e减少大鼠体内可卡因自我给药（FR2；1-10