1,6-bis(o-carboxyphenoxy)hexane | 194344-15-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,6-bis(o-carboxyphenoxy)hexane
• 英文别名: 1,6-bis(carboxyphenoxy)-hexane；2-[6-(2-carboxyphenoxy)hexoxy]benzoic acid
• CAS: 194344-15-5
• 化学式: C₂₀H₂₂O₆
• 分子量: 358.391
• InChiKey: ZIXYVUSKSDPHPW-UHFFFAOYSA-N

物化性质

• 沸点：
  582.2±35.0 °C(Predicted)
• 密度：
  1.238±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  26
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,6-bis(o-carboxyphenoxy)hexane 、 乙酸酐 生成 Acetyl 2-[6-(2-acetyloxycarbonylphenoxy)hexoxy]benzoate
  参考文献：
  名称：

  WO2008/51565

  摘要：

  公开号：
• 作为产物：
  描述：

  1,6-二溴己烷 、 水杨酸 在 sodium hydroxide 、 水 作用下， 反应 39.0h， 生成 1,6-bis(o-carboxyphenoxy)hexane
  参考文献：
  名称：

  WO2008/51565

  摘要：

  公开号：

文献信息

• Therapeutic compositions and methods
  申请人：——

  公开号：US20020106345A1

  公开（公告）日：2002-08-08

  Methods of promoting healing through enhanced regeneration of tissue (e.g. hard tissue or soft tissue) by contacting the tissue or the surrounding tissue with an anti-inflammatory agent. These methods are useful in a variety of dental and orthopedic applications.

  通过使用抗炎药物接触组织或周围组织，促进组织（如硬组织或软组织）增强再生的方法。这些方法在各种牙科和骨科应用中很有用。
• Polyanhydrides with biologically active degradation products
  申请人：Rutgers, the State University of New Jersey

  公开号：EP1464673A2

  公开（公告）日：2004-10-06

  Polyanhydrides which degrade into biologically active compounds are disclosed.

  公开了可降解成具有生物活性化合物的聚酸酐。
• SURGICAL STAPLER BUTTRESS ASSEMBLY WITH HUMIDITY TOLERANT ADHESIVE
  申请人：Ethicon Endo-Surgery, LLC

  公开号：EP3162384A1

  公开（公告）日：2017-05-03

  A buttress assembly is configured to temporarily adhere to a wet surgical stapler end effector. The buttress assembly includes a buttress body and a humidity tolerant adhesive. The adhesive includes a bioabsorbable polymer having a block configuration selected from the group consisting of A-B-A and A-B-C. The A block is a bioabsorbable homopolymer that may be characterized by a glass transition temperature of at least about 0°C, a crystallinity as measured by X-ray diffraction of at least about 30%, and a melting temperature of at least about 50°C. The B block is a bioabsorbable homopolymer or co-polymer that may be characterized by a glass transition temperature of at least about -40°C, a crystallinity as measured by X-ray diffraction of at most about 25%, and a molecular weight of from about 20 to about 80kDa. The C block is a bioabsorbable hydrophilic homopolymer or co-polymer that may be miscible with water at 37°C.

  托架组件用于临时粘附到湿手术订书机末端效应器上。支撑组件包括支撑体和耐湿粘合剂。粘合剂包括一种生物可吸收聚合物，其嵌段结构选自 A-B-A 和 A-B-C。A 嵌段是一种生物可吸收均聚物，其玻璃化转变温度至少约为 0°C，X 射线衍射测定的结晶度至少约为 30%，熔化温度至少约为 50°C。B 嵌段是一种生物可吸收均聚物或共聚物，其特征是玻璃化转变温度至少约为 -40°C，X 射线衍射测定的结晶度至少约为 25%，分子量约为 20 至 80kDa。C 嵌段是一种可生物吸收的亲水性均聚物或共聚物，在 37°C 时可与水混溶。
• SURGICAL STAPLER BUTTRESS ASSEMBLY WITH MULTI-LAYER ADHESIVE
  申请人：Ethicon Endo-Surgery, LLC

  公开号：EP3162302A1

  公开（公告）日：2017-05-03

  A surgical stapler end effector assembly includes a staple cartridge, an end effector, and a buttress assembly. The cartridge included a plurality of staples and a deck. The cartridge is operable to drive the staples through the deck. The anvil includes an underside having a staple forming surface configured to receive staples driven through the deck. The buttress assembly is sized and configured to be coupled with the deck of the staple cartridge or the underside of the anvil. The buttress assembly includes a buttress body, a first adhesive layer, and a second adhesive layer. The first and second adhesive layers are formed of different materials. The first adhesive layer is laid over the buttress body. The second adhesive layer is laid over the first adhesive layer such that the first adhesive layer is interposed between the second adhesive layer and the buttress body.

  手术订书机末端效应器组件包括一个订书机盒、一个末端效应器和一个对接组件。订书机盒包括多个订书钉和一个甲板。盒体可操作以驱动钉书针穿过甲板。砧座包括一个底面，该底面具有一个订书钉成型表面，用于接收穿过甲板的订书钉。支撑组件的尺寸和配置可与订书机盒的甲板或砧座的底面连接。对接组件包括对接体、第一粘合层和第二粘合层。第一和第二粘合层由不同材料形成。第一粘合层铺设在对接体上。第二粘合剂层铺设在第一粘合剂层上，使第一粘合剂层位于第二粘合剂层和对接体之间。
• Method of applying a buttress to a surgical stapler end effector
  申请人：Ethicon Endo-Surgery, LLC

  公开号：US10166023B2

  公开（公告）日：2019-01-01

  A buttress is applied to an end effector of a surgical stapler. The buttress is loaded on a platform of a buttress applier cartridge. The end effector is closed upon the platform. An adhesive layer of the buttress secures the buttress to the end effector. The buttress is thus adhered to the end effector when the end effector is opened. The end effector is then actuated on tissue of a patient, thereby stapling the buttress to the tissue.

  在手术订书机的末端效应器上加载对头。对接器装载在对接器插件的平台上。末端效应器封闭在平台上。绷带的粘合层将绷带固定在末端效应器上。这样，当末端执行器打开时，托架就会粘附在末端执行器上。然后在病人的组织上启动末端效应器，从而将托架钉在组织上。