3,5-二氯-2,6-二甲氧基-4-甲基苯甲酸 | 60620-09-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3,5-二氯-2,6-二甲氧基-4-甲基苯甲酸
• 英文名称: 3,5-dichloro-2,6-dimethoxy-4-methyl-benzoic acid
• 英文别名: 3,5-Dichlor-2,6-dimethoxy-4-methyl-benzoesaeure；3.5-Dichlor-2.6-dimethoxy-4-methyl-benzoesaeure；3,5-Dichloro-2,6-dimethoxy-4-methylbenzoic acid
• CAS: 60620-09-9
• 化学式: C₁₀H₁₀Cl₂O₄
• 分子量: 265.093
• InChiKey: IJXPITYCMKPDJK-UHFFFAOYSA-N

物化性质

• 熔点：
  116-117 °C(Solv: isopropyl ether (108-20-3); ligroine (8032-32-4))
• 沸点：
  390.2±37.0 °C(Predicted)
• 密度：
  1.458 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,5-二氯-2,6-二甲氧基-4-甲基苯甲酸 在 三氯化铝 、 氯化亚砜 、 乙醚 作用下， 生成 2-(3,5-dichloro-2,6-dimethoxy-4-methyl-benzoyl)-3,5-dimethoxy-benzoic acid methyl ester
  参考文献：
  名称：

  Treatment of pulmonary hypertension during surgery with nitric oxide and vasodilators

  摘要：

  Purpose: To describe the effects of the combination of several therapies on the pulmonary circulation and cardiac function in a patient with severe pulmonary hypertension.Clinical features: We report the case of a female patient with chronic secondary pulmonary hypertension and cardiac failure who underwent right hemicolectomy under general anesthesia. Insertion of a pulmonary artery catheter before the operation revealed pulmonary artery pressure (PAP) of 55/24 mmHg which was lowered moderately by 40 parts per million (ppm) inhNO, During surgery, the patient presented an episode of atrial fibrillation with a slow, irregular heart rate of 45-50 min(-1) and variable systemic pressure. A dipyridamole DPD (0.2 mg.kg(-1)) bolus stabilized systemic pressure and increased heart rate and cardiac output. However, PAP did not change. Nitroglycerine infusion was started at 10 mg.hr(-1) shortly after the initiation of DPD, The patient responded favourably to combined inhNO, intravenous DPD and NTG therapy with a marked and sustained reduction of PAP and a systemic hemodynamic stability.Conclusion: We conclude that: 1) in combination with inhNO, DPD does not augment the inhNO-induced decrease in PAP; 2) DPD improves the hemodynamic profile and elevates cardiac output; 3) therapeutic combination (inhaled NO, NTG, DPD) has a potent effect an pulmonary pressure in cardiac failure patients.

  DOI：

  10.1007/bf03018946
• 作为产物：
  描述：

  3,5-dichloro-2,6-dimethoxy-4-methyl-benzoic acid methyl ester 在 sodium hydroxide 作用下， 生成 3,5-二氯-2,6-二甲氧基-4-甲基苯甲酸
  参考文献：
  名称：

  62.蓖麻酚，对-熊果酸和间苯三酚羧酸的甲基醚的卤素衍生物

  摘要：

  DOI：

  10.1039/jr9390000280

文献信息

• Calam et al., Biochemical Journal, 1933, vol. 33, p. 579,587
  作者：Calam et al.

  DOI：——

  日期：——
• FLORVALL, L.;PERSSON, M. -L.;OERGEN, S. -O., ACTA PHARM. SUEC., 1983, 20, N 5, 365-370
  作者：FLORVALL, L.、PERSSON, M. -L.、OERGEN, S. -O.

  DOI：——

  日期：——
• Treatment of pulmonary hypertension during surgery with nitric oxide and vasodilators
  作者：Zu Yi Jiang、Tudor Costachescu、Marc Derouin、Gilbert Blaise

  DOI：10.1007/bf03018946

  日期：2000.6

  Purpose: To describe the effects of the combination of several therapies on the pulmonary circulation and cardiac function in a patient with severe pulmonary hypertension.Clinical features: We report the case of a female patient with chronic secondary pulmonary hypertension and cardiac failure who underwent right hemicolectomy under general anesthesia. Insertion of a pulmonary artery catheter before the operation revealed pulmonary artery pressure (PAP) of 55/24 mmHg which was lowered moderately by 40 parts per million (ppm) inhNO, During surgery, the patient presented an episode of atrial fibrillation with a slow, irregular heart rate of 45-50 min(-1) and variable systemic pressure. A dipyridamole DPD (0.2 mg.kg(-1)) bolus stabilized systemic pressure and increased heart rate and cardiac output. However, PAP did not change. Nitroglycerine infusion was started at 10 mg.hr(-1) shortly after the initiation of DPD, The patient responded favourably to combined inhNO, intravenous DPD and NTG therapy with a marked and sustained reduction of PAP and a systemic hemodynamic stability.Conclusion: We conclude that: 1) in combination with inhNO, DPD does not augment the inhNO-induced decrease in PAP; 2) DPD improves the hemodynamic profile and elevates cardiac output; 3) therapeutic combination (inhaled NO, NTG, DPD) has a potent effect an pulmonary pressure in cardiac failure patients.
• 62. Halogen derivatives of the methyl ethers of orcinol, p-orsellinic acid and phloroglucinolcarboxylic acid
  作者：C. T. Calam、A. E. Oxford

  DOI：10.1039/jr9390000280

  日期：——