(2-fluoro-4-nitro-phenyl)-bis-(2-methoxy-ethyl)-amine | 915019-79-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-fluoro-4-nitro-phenyl)-bis-(2-methoxy-ethyl)-amine
• 英文别名: (2-Fluoro-4-nitro-phenyl)-bis-(2-methoxy-ethyl)-amine；2-fluoro-N,N-bis(2-methoxyethyl)-4-nitroaniline
• CAS: 915019-79-3
• 化学式: C₁₂H₁₇FN₂O₄
• 分子量: 272.276
• InChiKey: YDFIKIVFQKMFET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  67.5
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  双(2-甲氧基乙基)胺 、 3,4-二氟硝基苯 在 potassium carbonate 作用下， 以 二甲基亚砜 为溶剂， 反应 5.5h， 生成 (2-fluoro-4-nitro-phenyl)-bis-(2-methoxy-ethyl)-amine
  参考文献：
  名称：

  WO2006/122806

  摘要：

  公开号：

文献信息

• 1,3-Dihydro-Imidazo [4,5-C] Quinolin-2-Ones as Lipid Kinase Inhibitors
  申请人：Garcia-Echeverria Carlos

  公开号：US20080194579A1

  公开（公告）日：2008-08-14

  The invention relates to novel organic compounds of formula (I) processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof—alone or in combination with one or more other pharmaceutically active compounds—for the treatment of an inflammatory or obstructive airway disease, such as asthma, disorders commonly occurring in connection with transplantation, or a proliferative disease, such as a tumor disease.

  本发明涉及公式（I）的新有机化合物，其制备方法，其在治疗人体或动物的过程中的应用，其单独或与一种或多种其他药物活性化合物结合使用，用于治疗炎症或阻塞性呼吸道疾病，如哮喘，与移植相关的常见疾病或增生性疾病，如肿瘤疾病。
• 1,3-DIHYDRO-IMIDAZO[4,5-C]QUINOLIN-2-ONES AS LIPID KINASE INHIBITORS
  申请人：Garcia-Echeverria Carlos

  公开号：US20100056558A1

  公开（公告）日：2010-03-04

  The invention relates to novel organic compounds of formula (I) processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof—alone or in combination with one or more other pharmaceutically active compounds—for the treatment of an inflammatory or obstructive airway disease, such as asthma, disorders commonly occurring in connection with transplantation, or a proliferative disease, such as a tumor disease.

  本发明涉及公式（I）的新有机化合物，其制备方法，其在处理人或动物体的过程中的应用，其单独使用或与一个或多个其他药物活性化合物结合使用，用于治疗炎症或阻塞性呼吸道疾病，如哮喘，与移植有关的常见疾病或增生性疾病，如肿瘤疾病。
• 1,3-dihydro-imidazo[4,5-C]quinolin-2-ones as lipid kinase inhibitors
  申请人：Novartis AG

  公开号：US07994170B2

  公开（公告）日：2011-08-09

  The invention relates to novel organic compounds of formula (I) processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof—alone or in combination with one or more other pharmaceutically active compounds—for the treatment of an inflammatory or obstructive airway disease, such as asthma, disorders commonly occurring in connection with transplantation, or a proliferative disease, such as a tumor disease.

  本发明涉及式(I)的新型有机化合物，其制备方法，应用于人或动物体内处理过程，使用该化合物-单独或与一种或多种其他药物活性化合物结合-用于治疗炎症或阻塞性呼吸道疾病，如哮喘，常见于移植相关疾病或增生性疾病，如肿瘤疾病。
• Imidazoquinolines as lipid kinase inhibitors
  申请人：Garcia-Echeverria Carlos

  公开号：US20120207751A1

  公开（公告）日：2012-08-16

  The invention relates to a combination comprising compounds of formula (I) and one or more other antiproliferative compounds, hormones or radiation, pharmaceutical preparations comprising the combination thereof, and the application thereof in a process for the treatment of tumors.

  本发明涉及一种组合物，包括式(I)的化合物和一种或多种其他抗增殖化合物、激素或辐射，以及包含该组合物的药物制剂，以及其在肿瘤治疗过程中的应用。
• 1,3-Dihydro-imidazo[4,5-c]quinolin-2-ones as Lipid Kinase Inhibitors
  申请人：GARCIA-ECHEVERRIA Carlos

  公开号：US20110251202A1

  公开（公告）日：2011-10-13

  The invention relates to novel organic compounds of formula (I) processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof—alone or in combination with one or more other pharmaceutically active compounds—for the treatment of an inflammatory or obstructive airway disease, such as asthma, disorders commonly occurring in connection with transplantation, or a proliferative disease, such as a tumor disease.

  本发明涉及式(I)的新型有机化合物，其制备方法，其在用于治疗人或动物体内的过程中的应用，其使用-单独或与一种或多种其他药物活性化合物结合使用-用于治疗炎症性或阻塞性呼吸道疾病，如哮喘，与移植有关的常见疾病或增殖性疾病，如肿瘤疾病。