4-Methyl-N-([(4-methylphenyl)amino]carbonyl)benzenesulfonamide | 51327-36-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Methyl-N-([(4-methylphenyl)amino]carbonyl)benzenesulfonamide
• 英文别名: N-(p-toluenesulfonyl)-N'-(p-tolyl)urea；N-(toluene-4-sulfonyl)-N'-p-tolyl-urea；N-(Toluol-4-sulfonyl)-N'-p-tolyl-harnstoff；N(2)-p-Tolyl-N(1)-(4-methylbenzenesulfonyl) Urea；1-p-Toluolsulfonyl-3-p-tolyl-harnstoff；1-(p-Tolyl)-3-(p-tolylsulfonyl)-urea；1-(4-methylphenyl)-3-(4-methylphenyl)sulfonylurea
• CAS: 51327-36-7
• 化学式: C₁₅H₁₆N₂O₃S
• 分子量: 304.37
• InChiKey: VBLCZOCTWIZHAL-UHFFFAOYSA-N

物化性质

• 熔点：
  152-154 °C
• 密度：
  1.303±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  83.6
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2935009090

反应信息

• 作为反应物：
  描述：

  4-Methyl-N-([(4-methylphenyl)amino]carbonyl)benzenesulfonamide 、 足球烯 在 1,10-菲罗啉 、 copper diacetate 作用下， 以 氯苯 为溶剂， 反应 4.0h， 以9%的产率得到
  参考文献：
  名称：

  Cu（OAc）2介导的C 60与尿素的反应制备全咪唑啉酮

  摘要：

  Cu（OAc）2介导的C 60与脲的分子间胺化反应使得简明而高效的全咪唑啉酮类化合物的制备涉及两个N–H键的断裂和两个C–N键的形成。可以使用该方法合成二烷基化和二芳基化的全氨基咪唑啉酮。

  DOI：

  10.1021/acs.joc.5b02682
• 作为产物：
  描述：

  对甲苯异硫氰酸酯 在 sodium hydroxide 、 双氧水 作用下， 生成 4-Methyl-N-([(4-methylphenyl)amino]carbonyl)benzenesulfonamide
  参考文献：
  名称：

  Shah et al., Journal Of Scientific and Industrial Research, 1959, vol. 18 B, p. 202

  摘要：

  DOI：

文献信息

• Improvements in or relating to benzenesulfonamido derivatives
  申请人：ELI LILLY AND COMPANY

  公开号：EP0166615A2

  公开（公告）日：1986-01-02

  This invention provides the use of certain benzenesulfonamide derivatives of the formula (I) wherein: R, and R3 are independently hydrogen, C,-C3 alkyl, halo, trifluoromethyl, or C1-C3 alkoxy; R2 is halo, methyl, or trifluoromethyl; and R4 is hydrogen, halo, methyl, ortrifluoromethyl, in the treatment of susceptible neoplasms in mammals. Also provided are certain novel benzenesulfonamide derivatives and their pharmaceutical formulations.

  本发明提供了式(I)的某些苯磺酰胺衍生物的用途，其中：R和R3独立地为氢、C,-C3烷基、卤代、三氟甲基或C1-C3烷氧基；R2为卤代、甲基或三氟甲基；R4为氢、卤代、甲基或三氟甲基，用于治疗哺乳动物的易感肿瘤。 还提供了某些新型苯磺酰胺衍生物及其药物制剂。
• Thermosensitive reversible colordeveloping and disappearing agent
  申请人：NEW OJI PAPER CO., LTD.

  公开号：EP0701905A1

  公开（公告）日：1996-03-20

  A thermosensitive reversible color-developing and disappearing agent includes an aromatic compound having at least one group of the formula, -SO₂NHCXNH-, wherein X = O or S atom, and at least one straight chain alkyl group with 11 or more carbon atoms, and is reactive with a dye precursor in a thermosensitive recording material to thereby record colored images on the recording material upon heating imagewise, and make the colored images disappear upon heating to a temperature lower than the colored image-forming temperature.

  一种热敏可逆显色剂和消失剂包括一种芳香族化合物，该化合物至少具有一个式-SO₂NHCXNH-的基团，其中 X = O 或 S 原子，以及至少一个具有 11 个或更多碳原子的直链烷基，并与热敏记录材料中的染料前体发生反应，从而在图像加热时在记录材料上记录彩色图像，并在加热到低于彩色图像形成温度时使彩色图像消失。
• Thermosensitive reversible recording material
  申请人：Oji Paper Co., Ltd.

  公开号：EP0888906A1

  公开（公告）日：1999-01-07

  A thermosensitive reversible recording material capable of forming and holding clear colored images with a high contrast and capable of being repeatedly color-developed and color-erased many times, has a thermosensitive recording layer formed on a substrate sheet and including, in addition to a substantially colorless dye precursor, a reversibly color-developing and color-erasing aromatic compound of the formula (I), and a color-erasing promoter compound of the formula II. R1 = naphthyl, phenyl or substituted phenyl group Y = -NHCO-, -SCONH-, -CONHCO-, -NHCONH-, etc., n = 10 to 29, A1, A2 = naphthyl or phenyl group R2, R3 = H, lower alkyl, lower alkoxy, aryl, halogen or aralkyl.

  一种能形成和保持高对比度的清晰彩色图像，并能多次重复显色和褪色的热敏可逆记录材料，其热敏记录层形成于基片上，除基本无色的染料前体外，还包括式（I）的可逆显色和褪色芳香族化合物，以及式（II）的褪色促进剂化合物。 R1 = 萘基、苯基或取代苯基 Y = -NHCO-、-SCONH-、-CONHCO-、-NHCONH-等、 n = 10 至 29、 A1、A2 = 萘基或苯基 R2、R3 = H、低级烷基、低级烷氧基、芳基、卤素或芳烷基。
• Thermosensitive recording material and novel color developer compounds
  申请人：OJI PAPER CO., LTD.

  公开号：EP1264707A2

  公开（公告）日：2002-12-11

  Disclosed is a thermosensitive recording material comprising a sheet-shaped support and a thermosensitive recording layer which is formed on at least one surface of the support and comprises a colorless or light-colored dye precursor and a color developer capable of reacting with the dye precursor and inducing color formation therein upon application of heat thereto, the color developer comprising a compound represented by the following formula (I) or analog thereof:: The thermosensitive recording material has high sensitivity and can prevent white background portions from coloring and recorded images from decolorizing in an environmental resistance test.

  本发明公开了一种热敏记录材料，它包括片状支架和热敏记录层，热敏记录层至少形成在支架的一个表面上，它包括无色或浅色染料前体和显色剂，显色剂能与染料前体发生反应，并在受热时形成颜色，显色剂包括下式(I)或其类似物所代表的化合物：： 热敏记录材料具有高灵敏度，在耐环境测试中可防止白色背景部分着色和记录的图像脱色。
• Thermosensitive recording materials
  申请人：Oji Paper Co., Ltd.

  公开号：EP1512545A1

  公开（公告）日：2005-03-09

  A thermosensitive recording material comprising a substrate sheet and a thermosensitive colored image-forming layer formed on at least one surface of the substrate sheet and comprising at least one colorless or light-colored dye precursor and a color-developing agent reactive with the dye precursor upon heating to thereby develop a color, wherein the color-developing agent comprises at least one compound of the formula (I):    (wherein R1 represents a member selected from the group consisting of unsubstituted aromatic hydrocarbon groups and substituted aromatic hydrocarbon groups with at least one substituent selected from the group consisting of a methyl group and a chlorine atom, and R2 represents a divalent organic group).

  一种热敏记录材料，包括基片和在基片的至少一个表面上形成的热敏彩色图像形成层，该热敏彩色图像形成层包括至少一种无色或浅色染料前体和在加热时与染料前体反应从而显色的显色剂，其中显色剂包括至少一种式(I)化合物： (其中 R1 代表选自由甲基和氯原子组成的组中的未取代的芳香烃基团和具有至少一个选自由甲基和氯原子组成的组中的取代基的取代芳香烃基团的成员，R2 代表二价有机基团）。