2-methoxy-5-methylbenzanilide | 147637-13-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methoxy-5-methylbenzanilide
• 英文别名: 2-methoxy-5-methyl-benzoic acid anilide；2-Methoxy-5-methyl-benzoesaeure-anilid；2-methoxy-5-methyl-N-phenylbenzamide
• CAS: 147637-13-6
• 化学式: C₁₅H₁₅NO₂
• 分子量: 241.29
• InChiKey: KYCLLOWVTDHKDQ-UHFFFAOYSA-N

物化性质

• 沸点：
  328.6±35.0 °C(Predicted)
• 密度：
  1.156±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-methoxy-5-methylbenzanilide 在 lithium hydroxide 、 正丁基锂 、 铜 、 锌 作用下， 以 丙醇 、 水 为溶剂， 反应 54.6h， 生成 2-Hydroxymethyl-6-methoxy-3-methyl-benzoic acid
  参考文献：
  名称：

  有机锂及相关试剂在合成中的应用。第13部分。基于芳族金属化的合成策略。苯甲酸简明的区域专一性转化为4-羟基-1-芳基萘

  摘要：

  3-未取代的邻苯二甲酸酯的合成（5）以及它们转化成1-羟基-1-芳基邻苯二甲酸酯（8），非常有用的异苯并呋喃的前体（10）以及随后将它们环加成乙炔二羧酸二甲酯，作为苯甲酸的区域特异性转化的一种方法描述了将丙烯酸转变成4-羟基-1-（2-甲氧基苯基）萘-2-3，3-二羧酸二甲酯（12）（绕轴高度取代的联芳基）。

  DOI：

  10.1016/s0040-4020(01)80334-3
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 乙醚 、 五氯化磷 作用下， 生成 2-methoxy-5-methylbenzanilide
  参考文献：
  名称：

  The Chemical Effects Accompanying Hydrogen Bonding. II. Alkylation of the Oximes of 2-Hydroxy-5-methylbenzophenone

  摘要：

  DOI：

  10.1021/ja01177a022

文献信息

• Opioid receptor modulators
  申请人：Janssen Pharmaceutica NV

  公开号：EP2298744A2

  公开（公告）日：2011-03-23

  The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.

  本发明涉及式（I）的新型阿片受体调节剂。 本发明还涉及制备此类化合物的方法、含有此类化合物的药物组合物，以及它们在治疗可通过调节阿片受体来改善或治疗的疾病中的用途。
• EFFICACY, SAFETY AND PATIENT SATISFACTION OUTCOMES OF THE AMS 700CX INFLATABLE PENILE PROSTHESIS: RESULTS OF A LONG-TERM MULTICENTER STUDY
  作者：CULLEY C. CARSON、JOHN J. MULCAHY、FRED E. GOVIER

  DOI：10.1016/s0022-5347(05)67364-8

  日期：2000.8

  Purpose: We performed a long-term multicenter study of the AMS 700CX double dagger 3-piece inflatable penile prosthesis, focusing on longevity, morbidity and patient satisfaction in men implanted up to 134 months with a median followup of 47.7 months.Materials and Methods: We performed a large scale retrospective multicenter study in 2 phases. Phase 1 was a medical record review of 372 men who underwent implantation with the AMS 700CX penile prosthesis from 1987 to 1996 by 7 frequent penile prosthesis implanters, Phase 2 included a structured telephone interview of 207 patients by a neutral observer.Results: For the 372 men in phase 1 mean device mechanical reliability plus or minus standard deviation was 92.1% +/- 3.3% affer 3 and 86.2% +/- 4.6% after 5 years. Patient age was 21 to 79 years (mean 57.6 +/- 11.0) at implantation. The etiology of erectile dysfunction was vascular in 27.7% of the cases, Peyronie's disease in 16.9%, diabetes mellitus in 12.9% and radical surgery in 11.6%. Of the men 55.6% received previous treatment for erectile dysfunction. Postoperative infection and device malfunction developed in 3.2% and 17.5% of the cases, respectively. Of the 207 men interviewed in phase 2, 86% still had an AMS 700CX penile prosthesis implanted, including 87.1% with erection suitable for coitus. Currently 79% of those with a device use it at least twice monthly and 88.2% would recommend an implant to a relative or friend.Conclusions: The AMS 700CX penile implant produced suitable erection and excellent patient satisfaction at long-term followup in the majority of men. Implant reliability is excellent and postoperative morbidity is low.
• Leuckart; Schmidt,M., Chemische Berichte, 1885, vol. 18, p. 2340
  作者：Leuckart、Schmidt,M.

  DOI：——

  日期：——
• NOVEL COMPOUNDS AS OPIOID RECEPTOR MODULATORS
  申请人：Janssen Pharmaceutica NV

  公开号：EP1725537B1

  公开（公告）日：2011-07-13
• Process for preparing intermediates of compounds useful as opioid receptor modulators
  申请人：Janssen Pharmaceutica NV

  公开号：EP2573068B1

  公开（公告）日：2014-12-31