2-[(4-Fluorophenyl)methoxy]benzohydrazide | 380335-30-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(4-Fluorophenyl)methoxy]benzohydrazide
• CAS: 380335-30-8
• 化学式: C₁₄H₁₃FN₂O₂
• mdl: MFCD02724827
• 分子量: 260.268
• InChiKey: MLPXPPHDKIFDDN-UHFFFAOYSA-N

物化性质

• 密度：
  1.264±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.071
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  溴化氰 、 2-[(4-Fluorophenyl)methoxy]benzohydrazide 在 碳酸氢钠 作用下， 以 甲醇 为溶剂， 反应 3.0h， 生成 5-[2-[(4-Fluorophenyl)methoxy]phenyl]-1,3,4-oxadiazol-2-amine
  参考文献：
  名称：

  Synthesis and anticonvulsant activity of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles

  摘要：

  A series of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles have been synthesized and evaluated as anticonvulsant agents. Compound 4b shows considerable anticonvulsant activity both in PTZ and MES models. It seems this effect is mediated through benzodiazepine receptors mechanism. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.02.014
• 作为产物：
  描述：

  methyl 2-[(4-fluorobenzyl)oxy]benzoate 在 一水合肼 作用下， 以 甲醇 为溶剂， 反应 5.0h， 生成 2-[(4-Fluorophenyl)methoxy]benzohydrazide
  参考文献：
  名称：

  Synthesis and anticonvulsant activity of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles

  摘要：

  A series of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles have been synthesized and evaluated as anticonvulsant agents. Compound 4b shows considerable anticonvulsant activity both in PTZ and MES models. It seems this effect is mediated through benzodiazepine receptors mechanism. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.02.014

文献信息

• THIAZEPINE DERIVATIVE
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2119719A1

  公开（公告）日：2009-11-18

  The present invention relates to a thiazepine derivative or a pharmacologically acceptable salt thereof having an excellent effect of inhibiting 11β-hydroxysteroid dehydrogenase type 1. A thiazepine derivative or a pharmacologically acceptable salt thereof having general formula (I): wherein R1 represents a hydrogen atom, a C1-C6 alkyl group or the like; R2 represents a C1-C6 alkyl group, a C1-C6 halogenated alkyl group, a C1-C6 hydroxyalkyl group, or the like; R3 represents a hydrogen atom or a C1-C6 alkyl group; R4 represents a C6-C10 aryl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group a or a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group a; Substituent Group a consists of a halogen atom, a C1-C6 alkyl group, a C6-C10 aryl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group b, and so forth; Substituent Group b consists of a halogen atom, a C1-C6 alkyl group, a C1-C6 halogenated alkyl group, and so forth.

  本发明涉及一种噻吩啶衍生物或其药理学上可接受的盐，具有优异的抑制11β-羟基类固醇脱氢酶1型的作用。具有通式（I）的噻吩啶衍生物或其药理学上可接受的盐： 其中 R1代表氢原子、C1-C6烷基或类似物；R2代表C1-C6烷基、C1-C6卤代烷基、C1-C6羟基烷基或类似物；R3代表氢原子或C1-C6烷基；R4代表可能被1至5个独立选择自取代基团a的基团取代的C6-C10芳基，或可能被1至3个独立选择自取代基团a的基团取代的杂环基团；取代基团a由卤原子、C1-C6烷基、可能被1至5个独立选择自取代基团b的基团取代的C6-C10芳基等组成；取代基团b由卤原子、C1-C6烷基、C1-C6卤代烷基等组成。
• Synthesis and anticonvulsant activity of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles
  作者：Afshin Zarghi、Sayyed A. Tabatabai、Mehrdad Faizi、Avideh Ahadian、Parisa Navabi、Vahideh Zanganeh、Abbas Shafiee

  DOI：10.1016/j.bmcl.2005.02.014

  日期：2005.4

  A series of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles have been synthesized and evaluated as anticonvulsant agents. Compound 4b shows considerable anticonvulsant activity both in PTZ and MES models. It seems this effect is mediated through benzodiazepine receptors mechanism. (c) 2005 Elsevier Ltd. All rights reserved.