2,3-dimethyl-terephthalic acid diamide | 99068-44-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3-dimethyl-terephthalic acid diamide
• 英文别名: 2,3-Dimethyl-terephthalsaeure-diamid；Dimethylterephthalamid；2,3-dimethylbenzene-1,4-dicarboxamide
• CAS: 99068-44-7
• 化学式: C₁₀H₁₂N₂O₂
• 分子量: 192.217
• InChiKey: HHKKOKUCMRJPET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  86.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,4-二溴-2,3-二甲基苯 在 吡啶 、 氢氧化钾 作用下， 生成 2,3-dimethyl-terephthalic acid diamide
  参考文献：
  名称：

  Extensive sterile abscess in an invasive fibrous thyroiditis (Riedel’s thyroiditis) caused by an occlusive vasculitis

  摘要：

  Riedel's thyroiditis is a rare disease determined by an invasive fibrosclerotic transformation of the thyroid gland. It may be one manifestation of multifocal fibrosis with still unknown etiology. Because it mimics carcinoma, a biopsy must be performed to get the correct diagnosis. The condition is self-limiting when confined to the neck. Prognosis depends on the extent of extracervical fibrosclerosis. We present a patient with a huge cervical and mediastinal, unilateral thyroid mass expanding to the aortic curve, which led to tracheal deviation and compression with symptoms of strider and dyspnea. These symptoms continued under a course of high-dose steroids; thus an operation was necessary to relieve the airway obstruction and limit inflammation. Intraoperative and pathological findings showed an inflammatory infiltration of the adjacent neck muscles and a sterile abscess caused by an occlusive vasculitis. Therefore, hemithyroidectomy had to be performed instead of a local limited resection. (C)2001, Editrice Kurtis.

  DOI：

  10.1007/bf03343824

文献信息

• PROCESS FOR ALKENYLATING CARBOXAMIDES
  申请人：Staffel Wolfgang

  公开号：US20090131657A1

  公开（公告）日：2009-05-21

  The present invention relates to a process for preparing N-(1-alkenyl)carboxamides of the formula I, which comprises reacting a carboxamide of the formula II with an alkyne of the formula III in the presence of a catalyst selected from among carbonyl complexes, halides and oxides of rhenium, manganese, tungsten, molybdenum, chromium and iron.

  本发明涉及一种制备式I的N-(1-烯基)羧酰胺的方法，包括在选择自铼、锰、钨、钼、铬和铁的羰基配合物、卤化物和氧化物之一作为催化剂的情况下，将式II的羧酰胺与式III的炔烃反应。
• PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING
  申请人：GUNZNER Janet L.

  公开号：US20110092461A1

  公开（公告）日：2011-04-21

  The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R 1 , R 2 , R 3 , R 4 , m and n are as described herein.

  本发明提供了新型的刺猬信号抑制剂，可用作治疗恶性肿瘤的治疗剂，其中化合物具有一般式I：其中A、X、Y、R1、R2、R3、R4、m和n如本文所述。
• Reactive ink printing process
  申请人：SAWGRASS SYSTEMS, INC.

  公开号：EP1762396A2

  公开（公告）日：2007-03-14

  The present invention relates to the field of digital printing, for example using a thermal printer and sublimation inks to form an image. In one aspect of the invention there is provided a method of digital printing of ink comprising dyes or pigments as colorants, comprising printing an image onto a substrate to form a printed image on the substrate, and subsequently activating the ink to permanently fix the printed image on the substrate, wherein the activating comprises bonding and/or cross-linking of the ink image on the substrate by the reaction between: a reactant comprising a compound with a functional group capable of reacting with active hydrogen, and a co-reactant comprising a compound with a functional group containing active hydrogen. Another aspect of the invention relates to transfer printing, in which an image is printed onto an intermediate substrate to form a printed image on the intermediate substrate, and subsequently transferred a final substrate by activating the ink to permanently fix the printed image on the final substrate.

  本发明涉及数字印刷领域，例如使用热敏打印机和升华油墨形成图像。在本发明的一个方面中，提供了一种包含染料或颜料作为着色剂的油墨的数字印刷方法，包括将图像印刷到承印物上以在承印物上形成印刷图像，随后活化油墨以将印刷图像永久固定在承印物上，其中活化包括通过以下反应将承印物上的油墨图像粘合和/或交联：反应物，包括具有能与活性氢反应的官能团的化合物；共反应物，包括具有含活性氢的官能团的化合物。本发明的另一个方面涉及转移印刷，即在中间承印物上印刷图像，以在中间承印物上形成印刷图像，然后通过活化油墨将印刷图像永久固定在最终承印物上，从而转移到最终承印物上。
• Thiazolopyridine derivatives as adenosine receptor antagonists
  申请人：MERCK PATENT GMBH

  公开号：US11186592B2

  公开（公告）日：2021-11-30

  The invention relates to thiazolopyridine derivatives of the general formula I, and the use of the compounds of the present invention for the treatment and/or prevention of hyperproliferative or infectious diseases and disorders in mammals, especially humans, and pharmaceutical compositions containing such compound.

  本发明涉及通式 I 的噻唑并吡啶衍生物、 以及本发明化合物在治疗和/或预防哺乳动物（尤其是人类）增殖过度或感染性疾病和失调方面的用途，以及含有此类化合物的药物组合物。
• Process for the production of expanded reticulated polyethylene
  申请人：AGIP PETROLI S.p.A.

  公开号：EP0138265B1

  公开（公告）日：1989-04-05