(2R)-2-(N-((2E)-5-((2R)-2-(tert-butyldimethylsilyloxy)-propylamino)-5-methylhex-2-enoyl)-N-methylamino)-N-methyl-3-(2-naphthyl)-N-phenethylpropionamide | 202810-89-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (2R)-2-(N-((2E)-5-((2R)-2-(tert-butyldimethylsilyloxy)-propylamino)-5-methylhex-2-enoyl)-N-methylamino)-N-methyl-3-(2-naphthyl)-N-phenethylpropionamide
• 英文别名: (2R)-2-(N-((2E)-5-((2R)-2-(tert-butoxydimethylsilyloxy)propylamino)-5-methylhex-2-enoyl)-N-methylamino)-N-methyl-3-(2-naphthyl)-N-phenethylpropionamide；(E)-5-[[(2R)-2-[tert-butyl(dimethyl)silyl]oxypropyl]amino]-N,5-dimethyl-N-[(2R)-1-[methyl(2-phenylethyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]hex-2-enamide
• CAS: 202810-89-7
• 化学式: C₃₉H₅₇N₃O₃Si
• 分子量: 643.985
• InChiKey: YMCXZEHKCBPNFC-MJQDKKEISA-N

物化性质

• 沸点：
  740.0±60.0 °C(predicted)
• 密度：
  1.042±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.64
• 重原子数：
  46
• 可旋转键数：
  16
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.49
• 拓扑面积：
  61.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2R)-2-(N-((2E)-5-((2R)-2-(tert-butyldimethylsilyloxy)-propylamino)-5-methylhex-2-enoyl)-N-methylamino)-N-methyl-3-(2-naphthyl)-N-phenethylpropionamide 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 生成 (2R)-2-(N-((2E)-5-((2R)-2-hydroxypropylamino)-5-methylhex-2-enoyl)-N-methylamino)-N-methyl-3-(2-naphthyl)-N-phenethylpropionamide
  参考文献：
  名称：

  Compounds with growth hormone releasing properties

  摘要：

  揭示了新型肽衍生物、含有它们的组合物，以及它们用于治疗由生长激素缺乏引起的医学疾病的用途。这些肽具有以下式（I）的结构：##STR1## 其中a、b、A、R.sup.1、L.sup.1、D、R.sup.3、R.sup.4、R.sup.2、L.sup.2、E和G的定义如规范中所述。这些肽表现出更好的抗蛋白酶降解能力，从而提高了生物利用度。

  公开号：

  US05922770A1
• 作为产物：
  描述：

  n-甲基苯基乙胺 在 N-羟基-7-氮杂苯并三氮唑 、 3 A molecular sieve 、 sodium cyanoborohydride 、 溶剂黄146 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三氟乙酸 作用下， 以 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 52.5h， 生成 (2R)-2-(N-((2E)-5-((2R)-2-(tert-butyldimethylsilyloxy)-propylamino)-5-methylhex-2-enoyl)-N-methylamino)-N-methyl-3-(2-naphthyl)-N-phenethylpropionamide
  参考文献：
  名称：

  New highly potent dipeptidic growth hormone secretagogues with low molecular weight

  摘要：

  Based on NN703, low molecular weight growth hormone secretagouges (GHSs) with a reduced number of hydrogen binding sites were designed by removal of the C-terminal amide group. The compounds were highly potent in combination with high efficacy in a rat pituitary cell assay, being characterized with EC50 values down to 0.8 nM. Selected compounds were tested in in vivo animal models. The oral bioavailability in dogs was 16-44%. Also, the ED50 values of the compounds were determined both in dog and swine. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

  DOI：

  10.1016/s0223-5234(00)00160-4

文献信息

• Compounds with growth hormone releasing properties
  申请人：NOVO NORDISK A/S

  公开号：EP1184370B1

  公开（公告）日：2005-09-14
• New highly potent dipeptidic growth hormone secretagogues with low molecular weight
  作者：B Peschke

  DOI：10.1016/s0223-5234(00)00160-4

  日期：2000.6

  Based on NN703, low molecular weight growth hormone secretagouges (GHSs) with a reduced number of hydrogen binding sites were designed by removal of the C-terminal amide group. The compounds were highly potent in combination with high efficacy in a rat pituitary cell assay, being characterized with EC50 values down to 0.8 nM. Selected compounds were tested in in vivo animal models. The oral bioavailability in dogs was 16-44%. Also, the ED50 values of the compounds were determined both in dog and swine. (C) 2000 Editions scientifiques et medicales Elsevier SAS.