2-(dimethylamino)benzohydrazide | 86601-75-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(dimethylamino)benzohydrazide
• CAS: 86601-75-4
• 化学式: C₉H₁₃N₃O
• mdl: MFCD00087186
• 分子量: 179.222
• InChiKey: RJKMSKGGKGSSPH-UHFFFAOYSA-N

物化性质

• 密度：
  1.156±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  58.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(dimethylamino)benzohydrazide 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 2.33h， 生成 1-[5-[2-(dimethylamino)phenyl]-2-(3,4,5-trimethoxyphenyl)-2H-1,3,4-oxadiazol-3-yl]ethanone
  参考文献：
  名称：

  New Antimitotic Agents with Activity in Multi-Drug-Resistant Cell Lines and in Vivo Efficacy in Murine Tumor Models

  摘要：

  During a screen for compounds that could inhibit cell proliferation, a series of new tubulin-binding compounds was identified with the discovery of oxadiazoline 1 (A-105972). This compound showed good cytotoxic activity against non-multi-drug-resistant and multi-drug-resistant cancer cell lines, but its utility in vivo was limited by a short half-life. Medicinal chemistry efforts led to the discovery of indolyloxazoline 22g (A-259745), which maintained all of the in vitro activity seen with oxadiazoline 1, but also demonstrated a better pharmacokinetic profile, and dose-dependent in vivo activity. Over a 28 day study, indolyloxazoline 22g increased the life span of tumor-implanted mice by up to a factor of 3 upon oral dosing. This compound, and others of its structural class, may prove to be useful in the development of new chemotherapeutic agents to treat human cancers.

  DOI：

  10.1021/jm010231w
• 作为产物：
  描述：

  tert-butyl N-[[2-(dimethylamino)benzoyl]amino]carbamate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 2-(dimethylamino)benzohydrazide
  参考文献：
  名称：

  New Antimitotic Agents with Activity in Multi-Drug-Resistant Cell Lines and in Vivo Efficacy in Murine Tumor Models

  摘要：

  During a screen for compounds that could inhibit cell proliferation, a series of new tubulin-binding compounds was identified with the discovery of oxadiazoline 1 (A-105972). This compound showed good cytotoxic activity against non-multi-drug-resistant and multi-drug-resistant cancer cell lines, but its utility in vivo was limited by a short half-life. Medicinal chemistry efforts led to the discovery of indolyloxazoline 22g (A-259745), which maintained all of the in vitro activity seen with oxadiazoline 1, but also demonstrated a better pharmacokinetic profile, and dose-dependent in vivo activity. Over a 28 day study, indolyloxazoline 22g increased the life span of tumor-implanted mice by up to a factor of 3 upon oral dosing. This compound, and others of its structural class, may prove to be useful in the development of new chemotherapeutic agents to treat human cancers.

  DOI：

  10.1021/jm010231w

文献信息

• [EN] [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINES<br/>[FR] [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINES
  申请人：BAYER AG

  公开号：WO2021028382A1

  公开（公告）日：2021-02-18

  The present invention covers [1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds of general formula (I) in which R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.

  本发明涵盖了通式（I）中R1、R2、R3、R4、R5、R6、R7和R8如所定义的[1,2,4]三唑并[1,5-c]喹唑啉-5-胺化合物，以及制备所述化合物的方法，用于制备所述化合物的有用中间体化合物，包含所述化合物的药物组合物和组合物，以及利用所述化合物制造用于治疗或预防疾病的药物组合物，特别是癌症或与异常AHR信号传导相关的疾病，或与失调免疫反应或其他与异常AHR信号传导相关的疾病有关的情况，作为唯一药剂或与其他活性成分组合使用。
• Decomposition of 2-dialkylaminobenzoyl azides to yield isocyanates and 1,1-dialkylindazol-1-ium-3-olates
  作者：Norman M. Waldron、Muhammad Raza

  DOI：10.1039/p19960000271

  日期：——

  Substituted benzoyl azides normally yield the correspondingly substituted isocyanates but when a dialkylated amino group is in the 2-position, in addition to the isocyanate, the 1,1-dialkylated indazol-1-ium-3-olate is produced. The ratio of the two products is very variable depending upon the substitution in the benzene ring. Largest yields of the zwitterionic products were found when there was a substituent in the 3-position regardless of whether the substituent was electron-donating or -withdrawing.

  取代苯甲酰叠氮通常产生相应的取代异氰酸酯，但当二烷基氨基团位于2位时，除了异氰酸酯外，还生成1,1-二烷基化的吲唑-1-鎓-3-氧酸盐。这两种产物的比例非常可变，取决于苯环上的取代情况。无论3位的取代基是电子供体还是电子受体，当3位有取代基时，偶极离子的产率最高。
• [EN] HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS<br/>[FR] INHIBITEURS D'ANGIOGENESE A BASE D'HYDRAZIDE ET D'ALCOXYAMIDE
  申请人：ABBOTT LAB

  公开号：WO2001079157A1

  公开（公告）日：2001-10-25

  Compounds having the formula are methionine aminopeptidase type 2 (MetAP2) inhibitors and are useful for inhibiting angiogenesis. Also disclosed are MetAP2-inhibiting compositions and methods of inhibiting angiogenesis in a mammal.

  具有公式的化合物是蛋氨酸氨肽酶2型（MetAP2）抑制剂，并且对于抑制血管生成具有用处。还披露了MetAP2抑制剂组合物和在哺乳动物中抑制血管生成的方法。
• MODIFIED NATURAL RUBBER, PROCESS FOR PRODUCTION OF THE SAME, AND RUBBER COMPOSITION AND TIRE EACH COMPRISING THE SAME
  申请人：Bridgestone Corporation

  公开号：EP2206730A1

  公开（公告）日：2010-07-14

  This invention provides a modified natural rubber producible at a lower cost than the conventional techniques and capable of improving the low loss factor, wear resistance and fracture characteristics of the rubber composition using the modified natural rubber as the rubber component in the rubber composition, and a method for producing the modified natural rubber. This invention provides a modified natural rubber formed by adding a hydrazide compound having a polar group to at least one natural rubber raw material selected from the group consisting of a natural rubber, a coagulated natural rubber latex and a natural rubber cup lump, a rubber composition using the modified natural rubber, and a tire using the rubber composition in any tire member.

  本发明提供了一种改性天然橡胶，其生产成本低于传统技术，并且能够改善橡胶组合物的低损耗因子、耐磨性和断裂特性，橡胶组合物中使用改性天然橡胶作为橡胶成分，本发明还提供了一种生产改性天然橡胶的方法。本发明提供了一种通过向至少一种天然橡胶原料添加具有极性基团的酰肼化合物而形成的改性天然橡胶，该天然橡胶原料选自天然橡胶、凝固天然橡胶胶乳和天然橡胶杯状胶块组成的组，还提供了一种使用改性天然橡胶的橡胶组合物，以及一种在任何轮胎部件中使用该橡胶组合物的轮胎。
• Curtius, Journal fur praktische Chemie (Leipzig 1954), 1917, vol. <2> 95, p. 341
  作者：Curtius

  DOI：——

  日期：——