3-N-Piperidinobutanol | 41788-30-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-N-Piperidinobutanol
• 英文别名: 3-piperidin-1-yl-butan-1-ol；3-piperidino-butan-1-ol；1-(2-Hydroxyethylethyl) piperidine；3-piperidin-1-ylbutan-1-ol
• CAS: 41788-30-1
• 化学式: C₉H₁₉NO
• 分子量: 157.256
• InChiKey: IDUAOXZXTLZYIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-N-Piperidinobutanol 、 间甲氧基苯甲酰氯 生成 3-piperidin-1-ylbutyl 3-methoxybenzoate;hydrochloride
  参考文献：
  名称：

  FELFOELDI K.; MOLNAR A.; BARTOK M., ACTA CHIM. ACAD. SCI. HUNG. , 1976, 90, NO 1, 75-91

  摘要：

  DOI：
• 作为产物：
  描述：

  (+/-)-ethyl 3-piperidinobutanoate 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 3-N-Piperidinobutanol
  参考文献：
  名称：

  Carbamoylcholine homologs: synthesis and pharmacology at nicotinic acetylcholine receptors

  摘要：

  In a recent study, racemic 3-(N,N-dimethylamino)butyl-N,N-dimethylcarbamate (1) was shown to be a potent agonist at neuronal nicotinic acetylcholine receptors with a high selectivity for nicotinic over muscarinic acetylcholine receptors [Mol. Pharmacol. 64 (2003) 865-875]. Here we present the synthesis and pharmacological characterization of a series of analogs of 1, where the methyl group at C-3 has been replaced by different alkyl substituents. Ring systems have been incorporated into the carbon backbone of some of the molecules, or the amino group has been build into ring systems. Furthermore, the (+)- and (-)-enantiomers of I have been separated, and X-ray crystallography has revealed that (-)-1 possesses (S)-configuration. The compounds have been characterized pharmacologically at recombinant nicotinic receptor subtypes. The structure-activity relationship study has provided valuable insight into the mode of interactions of I and its analogs with neuronal nicotinic acetylcholine receptors. (C) 2004 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ejphar.2004.06.038

文献信息

• Diaminopyrimidinecarboxamide Derivative
  申请人：Nagashima Shinya

  公开号：US20090281072A1

  公开（公告）日：2009-11-12

  A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is provided. A pyrimidine derivative or a salt thereof, which has an arylamino or arylethylamino group which may be substituted with a specified substituent, at the 2-position, amino group substituted with benzyl group or the like, at the 4-position, and carbamoyl group which may be substituted, at the 5-position, is provided.

  提供了一种可用于预防或治疗呼吸系统疾病，特别是哮喘、慢性阻塞性肺疾病等与STAT 6有关的化合物。该化合物为嘧啶衍生物或其盐，其在2位具有可被取代的芳基氨基或芳基乙基氨基基团，4位具有氨基取代的苯甲基基团或类似基团，5位具有可被取代的氨基甲酰基团。
• DIAMINOPYRIMIDINECARBOXAMIDE DERIVATIVE
  申请人：Nagashima Shinya

  公开号：US20110294749A1

  公开（公告）日：2011-12-01

  A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is provided. A pyrimidine derivative or a salt thereof, which has an arylamino or arylethylamino group which may be substituted with a specified substituent, at the 2-position, amino group substituted with benzyl group or the like, at the 4-position, and carbamoyl group which may be substituted, at the 5-position, is provided.

  提供了一种可用于预防或治疗涉及STAT 6的呼吸系统疾病，特别是哮喘、慢性阻塞性肺疾病等的化合物。该化合物为嘧啶衍生物或其盐，其在2位具有可以被指定取代基取代的芳基氨基或芳基乙基氨基基团，在4位具有可以被苄基或类似物取代的氨基基团，并在5位具有可以被取代的氨基甲酰基团。
• Cyanate ester-based pressure sensitive adhesive
  申请人：CORNERSTONE RESEARCH GROUP, INC.

  公开号：EP2374853A1

  公开（公告）日：2011-10-12

  The pressure sensitive adhesive disclosed is based on a multifunctional cyanate ester component. Monofunctional cyanate ester components and structural modifiers are incorporated to tailor the thermal and mechanical properties. The presence of crosslinks in the cyanate ester-based system also enhances the solvent resistance. While many types of PSAs consist of multiple components, all contributing to one aspect of the PSA's performance, the cyanate ester PSA does not require the use of plasticizers or other additives to stabilize mechanical performance over a wide temperature range. The simplicity of the system eases processing and prevents the possibility of degradation of the material over time.

  所公开的压敏胶基于一种多功能氰酸酯成分。单官能团氰酸酯成分和结构改性剂的加入可调整热性能和机械性能。氰酸酯基体系中存在的交联也增强了耐溶剂性。许多类型的 PSA 都由多种成分组成，这些成分都有助于提高 PSA 的某一方面性能，而氰酸酯 PSA 则不需要使用增塑剂或其他添加剂，即可在较宽的温度范围内稳定机械性能。该系统的简易性简化了加工过程，并防止了材料随时间推移而降解的可能性。
• Cyanate ester-based elastomer
  申请人：CORNERSTONE RESEARCH GROUP, INC.

  公开号：EP2374831A1

  公开（公告）日：2011-10-12

  A cyanate ester elastomer is designed to be capable of withstanding a vacuum application such as space with low outgassing, have sufficient resistance to atomic oxygen, have high thermal stability, UV stability, low dielectric constant/loss, recover from elongation in excess of one hundred percent and elastomeric properties from -100 °C to 250 °C. When the cyanate ester elastomer is paired with other chemicals, it creates materials applicable as a seal, adhesive, or as an insulation material.

  氰酸酯弹性体可在真空环境（如太空）下使用，且放气量小，对原子氧有足够的抵抗力，具有高热稳定性、紫外线稳定性、低介电常数/损耗，伸长恢复率超过 100%，在 -100 °C 至 250 °C 温度范围内具有弹性体特性。当氰酸酯弹性体与其他化学品配对使用时，可制成密封、粘合或绝缘材料。
• Mannich; Handke; Roth, Chemische Berichte, 1936, vol. 69, p. 2122
  作者：Mannich、Handke、Roth

  DOI：——

  日期：——