3-amino-6-chloro-pyrazine-2-carboxylic acid 2-tert-butylcarbamoyl-1-methyl-vinyl ester | 28768-06-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-amino-6-chloro-pyrazine-2-carboxylic acid 2-tert-butylcarbamoyl-1-methyl-vinyl ester
• 英文别名: [(E)-4-(tert-butylamino)-4-oxobut-2-en-2-yl] 3-amino-6-chloropyrazine-2-carboxylate
• CAS: 28768-06-1
• 化学式: C₁₃H₁₇ClN₄O₃
• 分子量: 312.756
• InChiKey: YOCIOAAVZAZBHI-FNORWQNLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  107
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• NOVEL PROCESS FOR THE PREPARATION OF ACYLGUANIDINES AND ACYLTHIOUREAS
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20130109856A1

  公开（公告）日：2013-05-02

  The present invention relates to a novel process for the preparation of compounds of general formula (I) and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.

  本发明涉及一种新颖的制备通式(I)化合物及其盐的方法，特别是其与无机或有机酸和碱形成的生理上可接受的盐，这些化合物具有有价值的药理特性，特别是对上皮钠通道具有抑制作用，可用于治疗疾病，特别是肺部和气道疾病。
• [EN] NOVEL PROCESS FOR THE PREPARATION OF ACYLGUANIDINES AND ACYLTHIOUREAS<br/>[FR] NOUVEAU PROCÉDÉ POUR LA PRÉPARATION D'ACYLGUANIDINES ET D'ACYLTHIOURÉES
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2013064451A1

  公开（公告）日：2013-05-10

  The present invention relates to a novel process for the preparation of compounds of general formula (I) and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.

  本发明涉及一种新型制备通式（I）化合物及其盐的方法，特别是与无机或有机酸和碱形成的生理上可接受的盐，具有有价值的药理学性质，特别是对上皮钠通道具有抑制作用，用于治疗疾病，特别是肺部和气道疾病。
• [EN] NOVEL ANNELATED BENZAMIDES<br/>[FR] NOUVEAUX BENZAMIDES ANNELÉS
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2017028926A1

  公开（公告）日：2017-02-23

  The present invention relates to compouns of formula (I), wherein R1, R2, and Z- have one of the meanings as indicated in the specification or a pharmaceutically acceptable salt thereof, to the use of compounds of formula (I) as a medicament, to pharmaceutical composition comprising at least one compound of formula (I), as well as to medicament combinations containing one or more compounds of formula (I).

  本发明涉及式（I）的化合物，其中R1、R2和Z-具有规范中指示的含义之一，或其药学上可接受的盐，以化合物（I）作为药物的用途，以至少包含一种式（I）化合物的制药组合物，以及含有一种或多种式（I）化合物的药物组合。
• NOVEL ANNELATED BENZAMIDES
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20170050952A1

  公开（公告）日：2017-02-23

  The present invention relates to compounds of formula (I) wherein R 1 , R 2 , and Z − have one of the meanings as indicated in the specification or a pharmaceutically acceptable salt thereof, to the use of compounds of formula (I) as a medicament, to pharmaceutical composition comprising at least one compound of formula (I), as well as to medicament combinations containing one or more compounds of formula (I).

  本发明涉及式(I)的化合物，其中R1、R2和Z-具有规范中指定的含义或其药学上可接受的盐，以及化合物(I)作为药物的使用，包括至少一个化合物(I)的制药组合物，以及含有一种或多种化合物(I)的药物组合。
• US8791260B2
  申请人：——

  公开号：US8791260B2

  公开（公告）日：2014-07-29