3,5-二碘-2-羟基苯甲酰胺 | 18071-54-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3,5-二碘-2-羟基苯甲酰胺
• 中文别名: 2-羟基-3,5-二碘苯酰胺
• 英文名称: 3,5-Dijod-salicylsaeure-amid
• 英文别名: 3,5-Dijod-2-hydroxy-benzamid；3.5-Diiod-salicylamid；2-hydroxy-3,5-diiodo-benzoic acid amide；2-Hydroxy-3,5-dijod-benzoesaeure-amid；2-hydroxy-3,5-diiodobenzamide
• CAS: 18071-54-0
• 化学式: C₇H₅I₂NO₂
• 分子量: 388.931
• InChiKey: ZUAHWRJXKPGKRC-UHFFFAOYSA-N

物化性质

• 熔点：
  190-195 °C
• 沸点：
  323.0±42.0 °C(Predicted)
• 密度：
  2.580±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  3,5-二碘-2-羟基苯甲酰胺 在 对甲苯磺酸 、 三氯氧磷 作用下， 以 甲苯 为溶剂， 反应 12.0h， 生成 N-[(9-{[(1E)-(dimethylamino)methylene]amino}-5,7-diiodo-1,2-dihydrocyclopenta[b]chromen-3-yl)methylene]-N-methylmethanaminium perchlorate
  参考文献：
  名称：

  The Vilsmeier–Haack formylation of 2,3-dihydro-4H-1,3-benzoxazin-4-ones and isomeric 1,2-dihydro-4H-3,1-benzoxazin-4-ones: an effective approach to functionalized 2H-/4H-chromenes and tetrahydroacridines

  摘要：

  We found that 1,3- and isomeric 3,1-benzoxazin-4-ones react with the Vilsmeier reagent in vastly different ways. Thus, either 2H- or 4H-chromenes were obtained in good yields when 1,3-benzoxazin-4-ones were reacted at 75-80 degrees C, while the formylation of 3,1-benzoxazines at ambient temperature leads to acridine-9-one or 9-chloroacridine derivatives, depending on the amount of Vilsmeier reagent and the nature of substrate. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.06.069
• 作为产物：
  描述：

  methyl 3,5-diiodosalicylate 生成 3,5-二碘-2-羟基苯甲酰胺
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur
  申请人：A. H. Robins Company, Inc.

  公开号：US04705853A1

  公开（公告）日：1987-11-10

  Aromatic azepinones and thiones having the formula ##STR1## wherein; A is benzene, naphthalene, quinoline or pyridine; B is oxygen or sulfur; E is oxygen, sulfur or ##STR2## n is 1, 2 or 3; Z is an amino or a heterocyclic nitrogen-containing radical; R is hydrogen, loweralkyl, cycloalkyl or phenylloweralkyl; Y is halo, loweralkyl, loweralkoxy, diloweralkylamino, nitro, amino, loweracetylamino, trifluoromethyl, phenyl or phenyl substituted by one to three Y' radicals selected from halo, loweralkyl, loweralkoxy, diloweralkylamino, nitro, amino, loweracylamino or trifluoromethyl; and having antihistaminic utility, a process for the preparation thereof and chemical intermediates therefor are disclosed.

  芳香族氮杂七元酮和硫醚的化学式为##STR1##其中；A为苯、萘、喹啉或吡啶；B为氧或硫；E为氧、硫或##STR2##n为1、2或3；Z为氨基或含氮杂环的基团；R为氢、较低烷基、环烷基或苯基较低烷基；Y为卤素、较低烷基、较低烷氧基、二较低烷基氨基、硝基、氨基、较低乙酰氨基、三氟甲基、苯基或被从卤素、较低烷基、较低烷氧基、二较低烷基氨基、硝基、氨基、较低酰胺基或三氟甲基中选择的一个至三个Y'基团取代的苯基；具有抗组胺作用，公开了其制备方法和化学中间体。
• A facile approach for the synthesis of novel xanthene derivatives with Vilsmeier–Haack reagent
  作者：Oleg K. Farat、Ivan V. Ananyev、Svetlana A. Varenichenko、Ekaterina V. Zaliznaya、Victor I. Markov

  DOI：10.1007/s10593-019-02416-6

  日期：2019.1

  A series of new derivatives of formylxanthenes have been synthesized via the reaction of substituted 1,3-benzoxazines with Vilsmeier–Haack reagent. It has been shown that 1,3-benzoxazines unsubstituted in the aromatic part and 6-bromo-1,3-benzoxazines are rearranged into xanthene derivatives under heating at 80°C for 1.5 h. Substitution at the C-8 position of 1,3-benzoxazines, especially with electronegative

  通过取代的1,3-苯并恶嗪与Vilsmeier-Haack试剂的反应，合成了一系列新的甲氧杂蒽衍生物。已经表明，在80℃加热1.5小时，芳族部分中未取代的1，3-苯并恶嗪和6-溴-1，3-苯并恶嗪被重排为into吨衍生物。1,3-苯并恶嗪的C-8位取代，尤其是带负电基团，可显着抑制反应。因此，在C-6和C-8位置存在碘原子会导致反应时间最多增加8小时，而在C-8位置存在溴原子则需要加热到100°C持续11 h。
• Antiparasitic salicylanilide derivatives
  申请人：Janssen Pharmaceutica N.V.

  公开号：US04005218A1

  公开（公告）日：1977-01-25

  Compounds of the class of salicylanilides substituted in the 4-position of the anilino moiety with a --CH(CN)-Ar group wherein Ar is phenyl, substituted phenyl, thienyl, halothienyl or naphthalenyl, said salicylanilides being useful as parasiticides.

  苯甲酰苯胺类化合物，其在苯胺部分的4位上用--CH(CN)-Ar基团进行取代，其中Ar是苯基，取代苯基，噻吩基，卤代噻吩基或萘基，这些苯甲酰苯胺类化合物可用作寄生虫药物。
• A transgenic wheat with a stilbene synthase gene resistant to powdery mildew obtained by biolistic method
  作者：Hui Liang、Jin Zheng、Xiayu Duan、Baoqin Sheng、Shuange Jia、Daowen Wang、Junwen Ouyang、Jiayang Li、Liangcai Li、Wenzhong Tian、R. Hain、Xu Jia

  DOI：10.1007/bf02886041

  日期：2000.4

  Stilbene, a kind of phytoalexin, plays an important role in resistance to fungal and bacterial infection in plants. It strongly inhibits the growth of fungi and sprout of spore. Stilbene synthase gene (Vst1) obtained from grapevine has been transferred into common spring wheat Jinghong 5 by using the biolistic transformation method. Five transgenic plants (T-0) were obtained from the bombarded 2014 immature embryos. One immune plantlet and 3 plantlets with mid-resistance to powdery mildew were identified from the transgenic plants of T-3 generation which came from 2 T-0 transgenic plants.
• Fused aromatic oxazepinones and sulphur analogues thereof and their preparation and use in counteracting histamine
  申请人：A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation)

  公开号：EP0107930B1

  公开（公告）日：1990-11-28