2,6-dichloro-4-(pyrrolidin-1-yl)pyridine | 526223-90-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,6-dichloro-4-(pyrrolidin-1-yl)pyridine
• 英文别名: 2,6-Dichloro-4-pyrrolidino-pyridine；2,6-dichloro-4-pyrrolidin-1-ylpyridine
• CAS: 526223-90-5
• 化学式: C₉H₁₀Cl₂N₂
• 分子量: 217.098
• InChiKey: JAWUDSRPONXGIR-UHFFFAOYSA-N

物化性质

• 熔点：
  136 °C
• 沸点：
  360.4±42.0 °C(Predicted)
• 密度：
  1.347±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  三正丁基2-吡啶基锌 、 2,6-dichloro-4-(pyrrolidin-1-yl)pyridine 在 bis-triphenylphosphine-palladium(II) chloride 三苯基膦 作用下， 以 xylene 为溶剂， 反应 20.0h， 以50%的产率得到2-(6-(pyridin-2-yl)-4-(pyrrolidin-1-yl)pyridin-2-yl)pyridine
  参考文献：
  名称：

  Pyrrolidine-Containing Polypyridines: New Ligands for Improved Visible Light Absorption by Ruthenium Complexes

  摘要：

  A range of new electron-releasing pyrrolidine-containing bipyridines and terpyridines has been prepared via selective metalation-cross-coupling sequences. The obtained ligands have been involved in microwave-assisted ruthenium complexation leading to homoleptic complexes in high yield. The electron-donor effect of the pyrrolidine nucleus led to a notable improvement of visible light absorption and strong changes in the electrochemical behavior, opening new opportunities for the design of photovoltaic devices.

  DOI：

  10.1021/jo051994k
• 作为产物：
  描述：

  4-吡咯烷基吡啶 在 正丁基锂 、 N,N-二甲基乙醇胺 作用下， 以 正己烷 为溶剂， 反应 6.0h， 生成 2,6-dichloro-4-(pyrrolidin-1-yl)pyridine
  参考文献：
  名称：

  Pyrrolidine-Containing Polypyridines: New Ligands for Improved Visible Light Absorption by Ruthenium Complexes

  摘要：

  A range of new electron-releasing pyrrolidine-containing bipyridines and terpyridines has been prepared via selective metalation-cross-coupling sequences. The obtained ligands have been involved in microwave-assisted ruthenium complexation leading to homoleptic complexes in high yield. The electron-donor effect of the pyrrolidine nucleus led to a notable improvement of visible light absorption and strong changes in the electrochemical behavior, opening new opportunities for the design of photovoltaic devices.

  DOI：

  10.1021/jo051994k

文献信息

• Novel pyridine compounds, process for their preparation and compositions containing them
  申请人：Pal Manojit

  公开号：US20060084644A1

  公开（公告）日：2006-04-20

  The present invention provides new heterocyclic compounds, particularly substituted pyridines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.

  本发明提供了新的杂环化合物，特别是取代的吡啶，制备和使用这些杂环化合物的方法和组合物，以及治疗各种疾病和疾病状态的方法，包括动脉粥样硬化、关节炎、再狭窄、糖尿病肾病或血脂异常，或由Perlecan低表达介导的疾病状态。
• Pyridine compounds, process for their preparation and compositions containing them
  申请人：Reddy US Therapeutics, Inc.

  公开号：US07622486B2

  公开（公告）日：2009-11-24

  The present invention provides new heterocyclic compounds, particularly substituted pyridines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.

  本发明提供了新的杂环化合物，特别是取代的吡啶，制备和使用这些杂环化合物的方法和组合物，以及治疗各种疾病和疾病状态的方法，包括动脉粥样硬化，关节炎，再狭窄，糖尿病肾病或血脂异常，或由Perlecan低表达介导的疾病状态。
• 10.1002/adsc.202400720
  作者：Wang, Feijun、Frankowski, Kevin J.

  DOI：10.1002/adsc.202400720

  日期：——

  Numerous appropriately substituted pyridyl or phenyl groups serve as a particularly advantageous activation motif for the electrochemical oxidation of amines. Such groups enable a general, mild method for the electrochemical α‐functionalization of tertiary amines across numerous activating groups and amine scaffolds. Notably, the method accommodates an unprecedented range of nucleophile classes, allowing

  许多适当取代的吡啶基或苯基用作胺的电化学氧化的特别有利的活化基序。这些基团为跨众多活化基团和胺支架的叔胺电化学α-官能化提供了一种通用、温和的方法。值得注意的是，该方法适应了前所未有的亲核试剂类别，允许将不同的官能团引入易于制备的胺底物中。然后通过不对称双功能化、N-吡啶胺与其他活性胺的位点选择性功能化、ivosidenib 的正式合成以及 FDA 批准的药物或天然产物底物的多样化的应用来证明该方法的实用性。
• Parallel synthesis of 4-amino-2,6-dialkylamino-pyridines
  作者：Maria Menichincheri、Domenico Fusar Bassini、Markus Gude、Mauro Angiolini

  DOI：10.1016/s0040-4039(02)02585-6

  日期：2003.1

  In this letter a fast and useful parallel synthesis approach to 4-amino-2,6-dialkylamino-pyridines is described starting from commercially available 2,6-difluoro-3,5-dichloro-pyridine. Both symmetrical and unsymmetrical derivatives have been synthesized respectively in two or three steps in good yields. The method described is mild, adaptable to combinatorial purposes and applicable to a variety of amines. (C) 2002 Elsevier Science Ltd. All rights reserved.
• EP1805142A4
  申请人：——

  公开号：EP1805142A4

  公开（公告）日：2009-06-10