3-(1-dodecynyl)benzaldehyde | 138255-54-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(1-dodecynyl)benzaldehyde
• 英文别名: 3-dodec-1-ynylbenzaldehyde
• CAS: 138255-54-6
• 化学式: C₁₉H₂₆O
• 分子量: 270.415
• InChiKey: VCNFKEUUFPZRCZ-UHFFFAOYSA-N

物化性质

• 沸点：
  397.8±25.0 °C(Predicted)
• 密度：
  0.95±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  20
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-(1-dodecynyl)benzaldehyde 在 palladium/alumina 氢气 作用下， 以 乙酸乙酯 为溶剂， 以87%的产率得到3-十二烷基苯甲醛
  参考文献：
  名称：

  Syntheses and antifungal activity of pseudomycin side-chain analogues. Part 1

  摘要：

  We have described herein the syntheses of three novel series of aromatic ring containing pseudomycin side-chain analogues. Preliminary biological evaluations of these analogues clearly indicate that it is possible to synthesize rigid pseudomycin sidechain analogues without compromising in vitro antifungal activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00423-6
• 作为产物：
  描述：

  间溴苯甲醛 、 1-十二炔 在 copper(l) iodide 、 TEA 、 三苯基膦 、 palladium dichloride 作用下， 以 乙腈 为溶剂， 以51%的产率得到3-(1-dodecynyl)benzaldehyde
  参考文献：
  名称：

  Syntheses and antifungal activity of pseudomycin side-chain analogues. Part 1

  摘要：

  We have described herein the syntheses of three novel series of aromatic ring containing pseudomycin side-chain analogues. Preliminary biological evaluations of these analogues clearly indicate that it is possible to synthesize rigid pseudomycin sidechain analogues without compromising in vitro antifungal activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00423-6

文献信息

• 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and
  申请人：Hoechst-Roussel Pharmaceuticals Incorporated

  公开号：US05360811A1

  公开（公告）日：1994-11-01

  Novel 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols of the formula RCH(OR.sup.1)CH(NR.sup.2 R.sup.3)R.sup.4 or RCH.sub.2 CR.sup.35 (NR.sup.2 R.sup.3)R.sup.4 wherein R is ##STR1## wherein R.sup.5 is CH.sub.3 (CH.sub.2).sub.m C.tbd.C, CH.sub.3 (CH.sub.2).sub.m CH.dbd.CH,CH.sub.3 (CH.sub.2).sub.m CH.sub.2 CH.sub.2, ##STR2## wherein m is 3 to 15, n is 0 to 12, and W and X are independently hydrogen, hydroxy, alkyl, alkoxy, halogen, or trifluoromethyl, ##STR3## wherein R.sup.23 loweralkyl; Z is S, O, or C.dbd.O; and A is S or O; R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.35 and R.sup.40 are as defined in the specification, the optical isomers thereof, or the pharmaceutically acceptable salts thereof, intermediates and processes for the preparation thereof, and methods of reducing inflammation and cell proliferation, and relieving memory dysfunction, and inhibiting bacterial and fungal growth are disclosed.

  1-烷基、1-烯基和1-炔基芳基-2-氨基-1,3-丙二醇的公式为RCH(OR1)CH(NR2R3)R4或RCH2CR35(NR2R3)R4，其中R是##STR1##，其中R5是CH3(CH2)mC≡C，CH3(CH2)mCH═CH，CH3(CH2)mCH2CH2，##STR2##，其中m是3到15，n是0到12，W和X独立的是氢、羟基、烷基、烷氧基、卤素或三氟甲基，##STR3##，其中R23是较低烷基；Z是S、O或C═O；A是S或O；R1、R2、R3、R4、R35和R40按说明书定义，其光学异构体，或其药物可接受的盐，中间体及其制备方法，以及用于减少炎症和细胞增殖，缓解记忆功能障碍，抑制细菌和真菌生长的方法被披露。
• 1-alkyl-,1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and
  申请人：Hoechst Marion Roussel, Inc.

  公开号：US05614631A1

  公开（公告）日：1997-03-25

  Novel 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols, intermediates and processes for the preparation thereof, and methods of reducing inflammation and cell proliferation, and relieving memory dysfunction, and inhibiting bacterial and fungal growth are disclosed.

  本发明公开了一种1-烷基、1-烯基和1-炔基芳基-2-氨基-1,3-丙二醇、其中间体和制备方法，以及减轻炎症和细胞增殖、缓解记忆功能障碍和抑制细菌和真菌生长的方法。
• Substituted methylene amide derivatives as modulators of protein tyrosine phosphatases(ptps)
  申请人：Swinnen Dominique

  公开号：US20050124656A1

  公开（公告）日：2005-06-09

  The present invention is related to substituted methylene amide derivatives of formula (I) and use thereof for the treatment and/or prevention of metabolic disorders mediated by insulin resistance or pyperglycemia, comprising diabetes type I and/or II, inadequate glucose tolerance, insulin resistance, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, obesity, polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of substituted methylene amide derivatives of formula (I) to modulate, notably to inhibit the activity of PTPs. Also the present invention relates to a method of treating diabetes type II, obesity and to regulate the appetite of mammals. The present invention is furthermore related to novel substituted methylene amide derivatives and method of preparation thereof. Formula (I).

  本发明涉及公式（I）的取代亚甲基酰胺衍生物及其用于治疗和/或预防由胰岛素抵抗或高血糖引起的代谢障碍，包括1型和/或2型糖尿病、不足的葡萄糖耐受性、胰岛素抵抗、高脂血症、高三酰甘油血症、高胆固醇血症、肥胖症、多囊卵巢综合症（PCOS）。特别是，本发明涉及使用公式（I）的取代亚甲基酰胺衍生物来调节，尤其是抑制PTP的活性。本发明还涉及一种治疗2型糖尿病、肥胖症和调节哺乳动物食欲的方法。此外，本发明还涉及新的取代亚甲基酰胺衍生物及其制备方法。公式（I）。
• 1-alkyl-,1-alkenyl-,and 1-alkynylaryl-2-amino-1,3-propanediols and
  申请人：Hoechst Roussel Pharmaceuticals Inc.

  公开号：US05534636A1

  公开（公告）日：1996-07-09

  Novel 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols, intermediates and processes for the preparation thereof, and methods of reducing inflammation and cell proliferation, and relieving memory dysfunction, and inhibiting bacterial and fungal growth are disclosed.

  本发明公开了一种1-烷基、1-烯基和1-炔基芳基-2-氨基-1,3-丙二醇，其中间体和制备方法，以及减少炎症和细胞增殖，缓解记忆功能障碍，抑制细菌和真菌生长的方法。
• 1-alkyl, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and
  申请人：Hoechst-Roussel Pharmaceuticals Inc.

  公开号：US05519062A1

  公开（公告）日：1996-05-21

  Novel 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols, intermediates and processes for the preparation thereof, and methods of reducing inflammation and cell proliferation, and relieving memory dysfunction, and inhibiting bacterial and fungal growth are disclosed.

  本发明公开了1-烷基，1-烯基和1-炔基芳基-2-氨基-1，3-丙二醇，其中间体和制备方法，以及减少炎症和细胞增殖，缓解记忆功能障碍和抑制细菌和真菌生长的方法。