3,5-吡啶二甲酸 | 102106-08-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 3,5-吡啶二甲酸
• 英文名称: Methyl (Z)-3-phenyl-2-propenyl 4-(3-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• 英文别名: cis-Cinnamyl methyl 4-(3-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate；3-O-methyl 5-O-[(Z)-3-phenylprop-2-enyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• CAS: 102106-08-1
• 化学式: C₂₅H₂₄N₂O₆
• 分子量: 448.475
• InChiKey: XTFPDGZNWTZCMF-FLIBITNWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-(3-nitrobenzylidene)acetoacetic acid cinnamyl ester 、 methyl (E)-3-aminocrotonate 生成 3,5-吡啶二甲酸
  参考文献：
  名称：

  KUTSUMA, TERUO;IKAWA, HIROSHI;SATO, YOSHIAKI

  摘要：

  DOI：

文献信息

• KUTSUMA, TERUO;IKAWA, HIROSHI;SATO, YOSHIAKI
  作者：KUTSUMA, TERUO、IKAWA, HIROSHI、SATO, YOSHIAKI

  DOI：——

  日期：——
• Stabilized pharmaceutical compositions containing a calcium channel blocker
  申请人：Wakiyama Naoki

  公开号：US20070142442A1

  公开（公告）日：2007-06-21

  The present invention provides a pharmaceutical composition containing a calcium channel blocker of the following formula or a pharmacologically acceptable salt thereof and a pharmacologically acceptable alkaline material which is added to an extent such that an aqueous solution or dispersion solution of said pharmaceutical composition containing a calcium channel blocker has a pH of at least 8: [wherein R 1 represents an optionally substituted C 1 -C 4 alkyl group, an amino group or a cyano group; R 2 represents an optionally substituted C 1 -C 4 alkyl group, a substituted C 3 -C 4 alkenyl group, or a substituted 4- to 6-membered cyclic amino group; R 3 represents a substituted phenyl group; R 4 represents an optionally substituted C 1 -C 4 alkoxycarbonyl group, a 1,3,2-phosphorinan-2-yl group, or a 5,5-dimethyl-1,3,2-phosphorinan-2-yl group, R 5 represents a C 1 -C 4 alkyl group].