N3-butyl-N1-aminoguanidine hydroiodide | 62400-55-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N3-butyl-N1-aminoguanidine hydroiodide
• 英文别名: 1-amino-3-(1-butyl)guanidine hydroiodide；1-Amino-3-butylguanidinehydroiodide；N-amino-N'-butyl-guanidine; hydriodide；N-Amino-N'-butyl-guanidin; Hydrojodid；1-amino-2-butylguanidine;hydroiodide
• CAS: 62400-55-9
• 化学式: C₅H₁₄N₄*HI
• 分子量: 258.105
• InChiKey: RLMGCWLYKZGMKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.18
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  76.4
• 氢给体数：
  4
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N3-butyl-N1-aminoguanidine hydroiodide 、 Toluene-4-sulfonate2-(4-formyl-phenyl)-1-methyl-imidazo[1,2-a]pyridin-1-ium; 在 氢溴酸 作用下， 以 乙醇 为溶剂， 生成 1-methyl-2-(4-(4-methylenenon-1-en-1-yl)phenyl)-3aH-indene
  参考文献：
  名称：

  Cationic antiprotozoal drugs. Trypanocidal activity of 2-(4'-formylphenyl)imidazo[1,2-a]pyridinium guanylhydrazones and related derivatives of quaternary heteroaromatic compounds

  摘要：

  A series of quaternary 2-phenylimidazo[1,2-a]pyridinum salts has been prepared and evaluated for antiparasitic activity. Primary attention was focused on derivatives with amido, substituted hydrazone, and heterocyclic functionality at the para position of the phenyl substituent. Guanylhydrazones and N-substituted guanylhydrazones of the 4'-formyl-substituted compounds are very active against the blood state Trypanosoma rhodesiense in mice by subcutaneous or oral administration. The most potent compounds attain 100% survival for 30 days at doses of less than 1.0 mg/kg (sc) and greater than 5.0 mg/kg (po). Weaker activity is noted for certain other 4'-substituents such as carboxamidines and carboxamide oximes. Considerable variation in structure, including replacing of the imidazo [1,2-a]pyridinium ring by other cationic heterocyclic rings and insertion of linking groups between the heterocyclic ring and phenyl group, can be done, and a high level of activity is maintained. Relationships between these structural changes and biological activity are discussed.

  DOI：

  10.1021/jm00163a049
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 乙醇 、 一水合肼 作用下， 生成 N3-butyl-N1-aminoguanidine hydroiodide
  参考文献：
  名称：

  Reduction of Nitroguanidine. V. The Synthesis of (a) α-Methyl-, (b) α-Ethyl-, (c) α-n-Butyl-γ-aminoguanidine¹

  摘要：

  DOI：

  10.1021/ja01296a036

文献信息

• [EN] AMINOGUANIDINE HYDRAZONES AS RETROMER STABILIZERS USEFUL FOR TREATING NEUROLOGICAL DISEASES<br/>[FR] HYDRAZONES D'AMINOGUANIDINE EN TANT QUE STABILISATEURS RÉTROMÈRES UTILES POUR LE TRAITEMENT DE MALADIES NEUROLOGIQUES
  申请人：OSPEDALE SAN RAFFAELE SRL

  公开号：WO2020201326A1

  公开（公告）日：2020-10-08

  The present invention relates to novel aminoguanidine hydrazone-derivatives of Formula (I) which are effective as retromer stabilizers and useful as neuroprotecting drugs. The invention also relates to pharmaceutical compositions comprising the compounds and their use in therapy and diagnostic.

  本发明涉及一种新型氨基胍肼酮衍生物，其化学式为（I），可作为逆转体稳定剂，用作神经保护药物。本发明还涉及包含这些化合物的药物组合物，以及它们在治疗和诊断中的用途。
• Acylamino triazoles as antiasthmatic agents
  申请人：Lilly Industries Limited

  公开号：US04089962A1

  公开（公告）日：1978-05-16

  1,2,3-triazoles and 1,2,4-triazoles having an N-substituted acylamino substituent are prepared by alkylating N-unsubstituted acylamino triazoles or acylating N-substituted amino triazoles. The N-substituted acylamino triazoles are useful as anti-allergy drugs. Pharmaceutical formulations containing acylamino triazoles and a method of treating allergic conditions utilizing such compounds are provided.

  本文介绍了通过烷基化N-未取代的酰胺基三唑或酰化N-取代的氨基三唑来制备具有N-取代酰胺基取代基的1,2,3-三唑和1,2,4-三唑。N-取代酰胺基三唑可用作抗过敏药物。本文提供了含有酰胺基三唑的制药配方以及利用这些化合物治疗过敏症的方法。
• Cationic antiprotozoal drugs. Trypanocidal activity of 2-(4'-formylphenyl)imidazo[1,2-a]pyridinium guanylhydrazones and related derivatives of quaternary heteroaromatic compounds
  作者：Richard J. Sundberg、Daniel J. Dahlhausen、G. Manikumar、B. Mavunkel、A. Biswas、V. Srinivasan、H. A. Musallam、Willis A. Reid、Arba L. Ager

  DOI：10.1021/jm00163a049

  日期：1990.1

  A series of quaternary 2-phenylimidazo[1,2-a]pyridinum salts has been prepared and evaluated for antiparasitic activity. Primary attention was focused on derivatives with amido, substituted hydrazone, and heterocyclic functionality at the para position of the phenyl substituent. Guanylhydrazones and N-substituted guanylhydrazones of the 4'-formyl-substituted compounds are very active against the blood state Trypanosoma rhodesiense in mice by subcutaneous or oral administration. The most potent compounds attain 100% survival for 30 days at doses of less than 1.0 mg/kg (sc) and greater than 5.0 mg/kg (po). Weaker activity is noted for certain other 4'-substituents such as carboxamidines and carboxamide oximes. Considerable variation in structure, including replacing of the imidazo [1,2-a]pyridinium ring by other cationic heterocyclic rings and insertion of linking groups between the heterocyclic ring and phenyl group, can be done, and a high level of activity is maintained. Relationships between these structural changes and biological activity are discussed.
• Reduction of Nitroguanidine. V. The Synthesis of (a) α-Methyl-, (b) α-Ethyl-, (c) α-n-Butyl-γ-aminoguanidine¹
  作者：G. W. Kirsten、G. B. L. Smith

  DOI：10.1021/ja01296a036

  日期：1936.5