N-(3,4,5-Trichlorphenyl)-2-hydroxybenzamid | 117367-27-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3,4,5-Trichlorphenyl)-2-hydroxybenzamid
• 英文别名: salicylic acid-(3,4,5-trichloro-anilide)；Salicylsaeure-(3,4,5-trichlor-anilid)；3',4',5'-trichlorosalicyl-anilide；3',4',5'-trichlorosalicylanilide；2-hydroxy-N-(3,4,5-trichlorophenyl)benzamide
• CAS: 117367-27-8
• 化学式: C₁₃H₈Cl₃NO₂
• 分子量: 316.571
• InChiKey: UVSHZSVDEWHXMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(3,4,5-Trichlorphenyl)-2-methoxybenzamid 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 以70%的产率得到N-(3,4,5-Trichlorphenyl)-2-hydroxybenzamid
  参考文献：
  名称：

  潜在抗雄激素的开发：N-（4-硝基-3-三氟甲基苯基）-环己酰胺和-苯甲酰胺、N-（3,4-二氯苯基）-和N-（3,4,5-三氯苯基）-苯甲酰胺

  摘要：

  为了开发潜在的非甾体抗雄激素，N-（4-硝基-3-三氟甲基苯基）-环己酰胺和-苯甲酰胺，以及 N-（3,4-二氯苯基）和 N-（3,4,5-三氯苯基）-苯甲酰胺合成的。羟基环己基化合物 3 对雄激素受体 (AR) 的亲和力明显高于羟基氟他胺。用羟基苯环取代羟基环己基环导致 AR 亲和力急剧下降。测试了具有 AR 亲和力的化合物的抗雄激素和雄激素作用。

  DOI：

  10.1002/ardp.19883210710

文献信息

• Sun protection compositions comprising semi-crystalline polymers and hollow latex particles
  申请人：Candau Didier

  公开号：US20090041691A1

  公开（公告）日：2009-02-12

  Topically applicable cosmetic/dermatological UV protection compositions having enhanced SPF contain at least one organic UV screening agent and/or at least one inorganic screening agent, such compositions also containing at least the following constituents (A) and (B): A) a semi-crystalline polymer which is solid at ambient temperature and has a melting point of greater than or equal to 30° C., containing a) a polymeric backbone and b) at least one crystallizable organic side chain and/or one crystallizable organic block forming part of the backbone of this said polymer, said polymer having a number-average molecular mass Mn of greater than or equal to 1,000, and B) hollow latex particles having a particle size ranging from 150 to 380 nm, formulated into a topically applicable, physiologically acceptable medium therefor.

  具有增强SPF的适用于化妆品/皮肤科的防紫外线保护组合物至少包含一种有机紫外线过滤剂和/或至少一种无机过滤剂，此类组合物还至少包含以下成分（A）和（B）： A）半结晶聚合物，室温下为固体，熔点大于或等于30°C，包含a）聚合骨架和b）至少一种可结晶有机侧链和/或作为该聚合物骨架一部分的可结晶有机块，该聚合物具有大于或等于1,000的数均分子质量Mn，以及 B）中空乳胶颗粒，粒径范围为150至380纳米，配制成适用于局部使用的、生理上可接受的介质。
• Topical Deodorant Compositions Based on Hydroxycitric Acid
  申请人：Gupta K Shyam

  公开号：US20070031526A1

  公开（公告）日：2007-02-08

  This invention relates to the use of Hydroxycitric acid and its derivatives in cosmetic and pharmaceutical compositions for reducing body malodor.

  这项发明涉及将羟基柠檬酸及其衍生物用于化妆品和药用组合物中，以减少身体异味。
• Cosmetic/sunscreen compositions containing dibenzoylmethane compounds and dithiolane compound photostabilizers therefor
  申请人：Lucet-Levannier Karine

  公开号：US20100086502A1

  公开（公告）日：2010-04-08

  Cosmetic/sunscreen compositions contain a combination of at least one dibenzoylmethane sunscreen compound and a photostabilizing amount of at least one dithiolane compound of formula (I) below:

  化妆品/防晒霜组合物含有至少一种二苯甲酮类防晒剂化合物和至少一种式（I）所示的二硫杂环化合物的光稳定量。
• [EN] USE OF AT LEAST ONE HYDROXYPROPYLTRIALKYLAMMONIUM DERIVATIVE AS DEODORANT AGENT<br/>[FR] UTILISATION D'AU MOINS UN DÉRIVÉ D'HYDROXYPROPYLTRIALKYLAMMONIUM EN TANT QU'AGENT DÉODORANT
  申请人：OREAL

  公开号：WO2015091860A1

  公开（公告）日：2015-06-25

  Use of at least one hydroxypropyltrialkylammonium derivative as deodorant agent The present invention relates to the use of one or more hydroxypropyltrialkylammonium derivatives of formula (I) as defined below for treating body odour, in particular underarm odour. The invention also relates to a process for treating body odour using a composition comprising such compounds. The invention similarly relates to a composition comprising, in a physiologically acceptable medium, one or more hydroxypropyltrialkylammonium derivatives of formula (I) and one or more antiperspirant active agents and/or one or more additional deodorant active agents. The present invention also relates to one or more particular hydroxypropyltrialkylammonium-based compounds.

  至少一种羟丙基三烷基铵衍生物作为除臭剂的使用。本发明涉及使用以下所定义的一个或多个羟丙基三烷基铵衍生物（式I）来治疗体臭，特别是腋臭。该发明还涉及使用包含这些化合物的组合物来治疗体臭的方法。该发明还涉及在生理上可接受的介质中包含一个或多个羟丙基三烷基铵衍生物（式I）和一个或多个止汗活性剂和/或一个或多个额外的除臭活性剂的组合物。本发明还涉及一个或多个特定的基于羟丙基三烷基铵的化合物。
• Artificially coloring the skin with a carotene compound, a xanthophyll compound and a lipophilic green dye composition
  申请人：Cassin Guillaume

  公开号：US20100150853A1

  公开（公告）日：2010-06-17

  A method for artificially coloring the skin entails topical application thereon of a composition containing, formulated into a physiologically acceptable medium: a) at least one compound of the carotene type, b) at least one compound of the xanthophyll type, c) at least one lipophilic green dye; the composition advantageously includes a mixture of dyes including: a) at least one compound of the carotene type, b) at least astaxanthin, c) at least one lipophilic green dye.

  一种人工着色皮肤的方法包括在皮肤上局部涂抹一种含有以下成分的组合物，配制成生理可接受的介质：a) 至少一种类胡萝卜素的化合物，b) 至少一种黄色素类的化合物，c) 至少一种亲脂性绿色染料；该组合物优选包括一种混合染料，其中包括：a) 至少一种类胡萝卜素的化合物，b) 至少一种虾青素，c) 至少一种亲脂性绿色染料。